There are 11 ways to get from Pisa to Santander by train, plane, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train to Florence Peretola Airport, fly to Santander Airport
best- Take the train from Pisa Centrale to Firenze S.M.N.train
- Fly from Florence Peretola Airport (FLR) to Santander Airport (SDR)plane FLR - SDR
8h 50m€101–355Fly Pisa International Airport to Bilbao Airport, bus
cheapest- Fly from Pisa International Airport (PSA) to Bilbao Airport (BIO)plane PSA - BIO
- Take the bus from Bilbao Intermodal to Estación de autobuses de Santanderbus
7h 8m€53–247Train, bus via Madrid
- Take the train from Pisa Centrale to Genova P.Za Principetrain Fb / ...
- Take the bus from Genoa to Marseillebus
- Take the train from Marseille St Charles to Madrid-Puerta de Atocha-Almudena Grandestrain
- Take the train from Madrid Chamartín to Santandertrain Alv / ...
24h 10m€243–426Bus
- Take the bus from Pisa to Nice Airportbus
- Take the bus from Nice Airport to Bilbaobus
- Take the bus from Bilbao Intermodal to Estación de autobuses de Santanderbus
25h 18m€129–199Drive 1,431.8 km
- Drive from Pisa to Santandercar 1,431.8 km
14h 5m€234–338Fly Pisa International Airport to Santander Airport
- Fly from Pisa International Airport (PSA) to Santander Airport (SDR)plane PSA - SDR
5h 5m€65–350Train, train to Bologna Guglielmo Marconi Airport, fly to Santander Airport
- Take the train from Pisa Centrale to Firenze S.M.N.train
- Take the train from Firenze S.M.N. to Bologna Centraletrain
- Fly from Bologna Guglielmo Marconi Airport (BLQ) to Santander Airport (SDR)plane BLQ - SDR
6h 39m€78–293Train to Florence Peretola Airport, fly to Bilbao Airport, bus
- Take the train from Pisa Centrale to Firenze S.M.N.train
- Fly from Florence Peretola Airport (FLR) to Bilbao Airport (BIO)plane FLR - BIO
- Take the bus from Bilbao Intermodal to Estación de autobuses de Santanderbus
8h 53m€100–271Fly Pisa International Airport to Adolfo Suárez Madrid–Barajas Airport, train
- Fly from Pisa International Airport (PSA) to Adolfo Suárez Madrid–Barajas Airport (MAD)plane PSA - MAD
- Take the train from Madrid Chamartín to Santandertrain
7h 49m€98–298Train, bus
- Take the train from Pisa Centrale to Ventimigliatrain Ic
- Take the train from Ventimiglia to Nice Saint-Augustintrain C3
- Take the bus from Nice Airport to Bilbaobus
- Take the bus from Bilbao Intermodal to Estación de autobuses de Santanderbus
25h 46m€142–228Train, bus #2
- Take the train from Pisa Centrale to Firenze S.M.N.train Re
- Take the train from Firenze S.M.N. to Padovatrain Fr
- Take the bus from Padova to Estación de autobuses de Santanderbus
29h 6m€158–213
Pisa to Santander by train and bus
Comparing Your Travel Options
The cheapest way to get from Pisa to Santander is to fly and bus which costs €50 - €250 and takes 7h 8m.
The fastest way to get from Pisa to Santander is to fly which takes 5h 5m and costs €65 - €350.
No, there is no direct bus from Pisa to Santander. However, there are services departing from Pisa and arriving at Estación de autobuses de Santander via Nice Airport and Bilbao Intermodal. The journey, including transfers, takes approximately 25h 18m.
The distance between Pisa and Santander is 1292 km. The road distance is 1431.8 km.
The best way to get from Pisa to Santander without a car is to train and bus via Madrid which takes 24h 10m and costs €240 - €430.
It takes approximately 8h 50m to get from Pisa to Santander, including transfers.
Pisa to Santander bus services, operated by FlixBus, depart from Pisa station.
The best way to get from Pisa to Santander is to bus which takes 25h 18m and costs €120 - €200. Alternatively, you can fly, which costs €65 - €350 and takes 5h 5m.
There is no direct flight from Pisa International Airport Airport to Santander Airport Airport. The quickest flight takes 11h 5m and has one stopover.
Pisa to Santander bus services, operated by FlixBus, arrive at Nice Airport station.
What companies run services between Pisa, Italy and Santander, Spain?
You can take a bus from Pisa to Estación de autobuses de Santander via Nice Airport, Bilbao, and Bilbao Intermodal in around 25h 18m. Alternatively, Ulendo Airlink, Iberia, and two other airlines fly from Pisa International Airport (PSA) to Santander Airport (SDR) once daily.
- Website
- vueling.com
Flights from Florence Peretola Airport to Santander Airport via Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 5h 5m
- When
- Every day
- Estimated price
- €90–210
Flights from Florence Peretola Airport to Santander Airport via Barcelona
- Ave. Duration
- 11h 5m
- When
- Monday and Friday
- Estimated price
- €90–210
Flights from Pisa International Airport to Santander Airport via Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 7h 57m
- When
- Monday, Wednesday, Thursday, and Sunday
- Estimated price
- €65–360
Flights from Bologna Guglielmo Marconi Airport to Santander Airport via Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 4h 35m
- When
- Every day
- Estimated price
- €90–430
Flights from Florence Peretola Airport to Bilbao Airport via Barcelona
- Ave. Duration
- 4h 5m
- When
- Monday and Thursday
- Estimated price
- €90–240
Flights from Florence Peretola Airport to Bilbao Airport via Paris Orly
- Ave. Duration
- 4h 20m
- When
- Sunday
- Estimated price
- €90–240
Flights from Pisa International Airport to Bilbao Airport via Paris Orly
- Ave. Duration
- 4h 15m
- When
- Sunday
- Estimated price
- €60–280
Flights from Pisa International Airport to Bilbao Airport via Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 5h 20m
- When
- Monday, Tuesday, Wednesday, Thursday, and Sunday
- Estimated price
- €40–240
Flights from Pisa International Airport to Bilbao Airport via Ibiza
- Ave. Duration
- 5h 20m
- When
- Monday to Friday
- Estimated price
- €55–240
Flights from Pisa International Airport to Bilbao Airport via Palma Mallorca
- Ave. Duration
- 7h 40m
- When
- Thursday
- Estimated price
- €55–240
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Pisa Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 22m
- Frequency
- Every 15 minutes
- Estimated price
- €9–13
- Website
- Trenitalia
Train from Pisa Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 22m
- Frequency
- Every 15 minutes
- Estimated price
- €9–13
- Website
- Trenitalia
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 28m
- Frequency
- 4 times a day
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Pisa Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 22m
- Frequency
- Every 15 minutes
- Estimated price
- €9–13
- Website
- Trenitalia
Train from Pisa Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 22m
- Frequency
- Every 15 minutes
- Estimated price
- €9–13
- Website
- Trenitalia
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- Flixbus
Bus from Genoa to Marseille
- Ave. Duration
- 6h 35m
- Frequency
- Every 4 hours
- Estimated price
- €30–50
- Website
- Flixbus
Bus from Pisa to Nice Airport
- Ave. Duration
- 5h 30m
- Frequency
- 5 times a week
- Estimated price
- €30–50
- Website
- Flixbus
Bus from Nice Airport to Bilbao
- Ave. Duration
- 16h 40m
- Frequency
- 3 times a week
- Estimated price
- €90–140
- Website
- Flixbus
Bus from Nice Airport to Bilbao
- Ave. Duration
- 16h 40m
- Frequency
- 3 times a week
- Estimated price
- €90–140
- Website
- Flixbus
Want to know more about travelling around Spain
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
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Booking & Getting There
Yes, the driving distance between Pisa to Santander is 1432 km. It takes approximately 14h 5m to drive from Pisa to Santander.
Volotea, Ulendo Airlink, Iberia and Ryanair offer flights from Pisa International Airport Airport to Santander Airport Airport.
Book your Pisa to Santander bus tickets online with Omio.
There are 2037+ hotels available in Santander.






