There are 7 ways to get from Pisa to Isernia by train (Trenitalia), bus, car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Trenitalia)
best- Take the train from Pisa Centrale to Roma Terminitrain Fb / ...
- Take the train from Roma Termini to Iserniatrain Re
6h 1m€57–133Bus via Rome
cheapest- Take the bus from Pisa to Roma, Autostazione Tiburtinabus N548 / ...
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
8h 40m€33–63Drive 507.4 km
- Drive from Pisa to Iserniacar 507.4 km
5h 1m€79–114Fly Pisa International Airport to Naples Airport, train
- Fly from Pisa International Airport (PSA) to Naples Airport (NAP)plane PSA - NAP
- Take the train from Caserta to Iserniatrain
7h 12m€61–226Train via Florence (Trenitalia)
- Take the train from Pisa Centrale to Firenze S.M.N.train Re
- Take the train from Firenze S.M.N. to Roma Terminitrain Fr
- Take the train from Roma Termini to Iserniatrain Re
6h 28m€60–131Bus
- Take the bus from Pisa to Cassinobus
- Take the bus from Cassino Piazza Garibaldi to Iserniabus Cb 015
9h 24m€33–47Bus to Florence Peretola Airport, fly to Fiumicino International Airport, train
- Take the bus from Pisa International Airport to Florence Airportbus
- Fly from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO)plane FLR - FCO
- Take the train from Roma Termini to Iserniatrain
6h 51m€99–260
Pisa to Isernia by train (Trenitalia)
Questions & Answers
The cheapest way to get from Pisa to Isernia is to bus which costs €30 - €50 and takes 9h 24m.
The fastest way to get from Pisa to Isernia is to drive which takes 5h 1m and costs €75 - €120.
No, there is no direct bus from Pisa to Isernia. However, there are services departing from Pisa and arriving at Isernia via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 8h 40m.
No, there is no direct train from Pisa to Isernia. However, there are services departing from Pisa Centrale and arriving at Isernia via Roma Termini. The journey, including transfers, takes approximately 6h 1m.
The distance between Pisa and Isernia is 516 km. The road distance is 507.4 km.
The best way to get from Pisa to Isernia without a car is to train which takes 6h 1m and costs €55 - €140.
It takes approximately 6h 1m to get from Pisa to Isernia, including transfers.
Pisa to Isernia bus services, operated by FlixBus, depart from Pisa station.
Pisa to Isernia train services, operated by Trenitalia Frecce, depart from Pisa Centrale station.
The best way to get from Pisa to Isernia is to train which takes 6h 1m and costs €55 - €140. Alternatively, you can bus via Rome, which costs €30 - €65 and takes 8h 40m.
What companies run services between Pisa, Italy and Isernia, Italy?
You can take a train from Pisa Centrale to Isernia via Roma Termini in around 6h 1m. Alternatively, you can take a bus from Pisa to Isernia via Roma, Autostazione Tiburtina in around 8h 40m.
- Website
- ryanair.com
Flights from Pisa International Airport to Naples Airport via Alghero
- Ave. Duration
- 3h 25m
- When
- Monday, Wednesday, and Friday
- Estimated price
- €55–190
Flights from Pisa International Airport to Naples Airport via Malta
- Ave. Duration
- 4h
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €55–190
Flights from Pisa International Airport to Naples Airport via Tirana
- Ave. Duration
- 4h 5m
- When
- Tuesday, Wednesday, Thursday, and Sunday
- Estimated price
- €55–190
Flights from Pisa International Airport to Naples Airport via Catania
- Ave. Duration
- 5h 5m
- When
- Saturday
- Estimated price
- €55–190
Flights from Pisa International Airport to Naples Airport via Palermo
- Ave. Duration
- 5h 10m
- When
- Thursday
- Estimated price
- €55–190
Flights from Pisa International Airport to Naples Airport via Cagliari
- Ave. Duration
- 5h 35m
- When
- Monday
- Estimated price
- €55–190
- Website
- ita-airways.com
Flights from Florence Peretola Airport to Fiumicino International Airport
- Ave. Duration
- 53 min
- When
- Every day
- Estimated price
- €55–140
- Website
- flyulendo.com
Flights from Pisa International Airport to Naples Airport via Tirana
- Ave. Duration
- 6h
- When
- Every day
- Estimated price
- €35–140
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Pisa Centrale to Roma Termini
- Ave. Duration
- 2h 53m
- Frequency
- Every 4 hours
- Estimated price
- €45–95
- Schedules at
- trenitalia.com
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 1h 42m
- Frequency
- Every 30 minutes
- Estimated price
- €35–75
- Schedules at
- trenitalia.com
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Pisa Centrale to Roma Termini
- Ave. Duration
- 4h 10m
- Frequency
- Every 4 hours
- Estimated price
- €40–70
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €23–40
- Website
- https://www.trenitalia.com/en.html
Train from Caserta to Isernia
- Ave. Duration
- 1h 18m
- Frequency
- 5 times a day
- Estimated price
- €11–19
- Website
- https://www.trenitalia.com/en.html
Train from Pisa Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 25m
- Frequency
- Every 30 minutes
- Estimated price
- €9–16
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 3h 52m
- Frequency
- 4 times a day
- Estimated price
- €30–55
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Pisa Centrale to Roma Termini
- Ave. Duration
- 3h 22m
- Frequency
- 3 times a day
- Estimated price
- €30–75
- Website
- https://www.trenitalia.com/en.html
Train from Firenze S.M.N. to Roma Termini
- Ave. Duration
- 2h 40m
- Frequency
- 6 times a week
- Estimated price
- €27–60
- Website
- https://www.trenitalia.com/en.html
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- https://www.flixbus.fr
Bus from Pisa to Roma, Autostazione Tiburtina
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- €25–45
- Website
- https://www.flixbus.co.uk
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- €12–21
- Website
- https://www.flixbus.co.uk
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Bus from Cassino Piazza Garibaldi to Isernia
- Ave. Duration
- 58 min
- Frequency
- 3 times a day
- Estimated price
- €2–4
- Schedules at
- atm-molise.it
- Phone
- +39 089 233 899
- salerno@autolineecurcio.it
- Website
- autolineecurcio.it
Bus from Pisa to Cassino
- Ave. Duration
- 7h 20m
- Frequency
- Once daily
- Estimated price
- €30–45
- Website
- https://www.autolineecurcio.it/
- info@flibco.com
- Website
- flibco.com
Bus from Pisa International Airport to Florence Airport
- Ave. Duration
- 1h
- Frequency
- Hourly
- Estimated price
- €15–35
- Website
- https://www.flibco.com/en
Want to know more about travelling around Italy
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More Questions & Answers
Pisa to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Pisa to Isernia train services, operated by Trenitalia Frecce, arrive at Roma Termini station.
Yes, the driving distance between Pisa to Isernia is 507 km. It takes approximately 5h 1m to drive from Pisa to Isernia.
Book your Pisa to Isernia train tickets online with Omio.
Book your Pisa to Isernia bus tickets online with Omio and FlixBus.
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