There are 8 ways to get from Pisa to Isernia by train (Trenitalia), bus, car, plane, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Pisa Centrale to Roma TiburtinaFa
- Take the train from Roma Tiburtina to IserniaRe
5h 23m€48–81Bus
cheapest- Take the bus from Pisa to Cassino
- Take the bus from Cassino Piazza Garibaldi to IserniaCb 015
9h 24m€4–6Bus via Rome
- Take the bus from Pisa to Roma, Autostazione TiburtinaN1508 / ...
- Take the bus from Roma, Autostazione Tiburtina to IserniaRome Tiburtina
7h 55m€20–58Drive 507.4 km
- Drive from Pisa to Isernia507.4 km
4h 58m€78–113Fly Pisa International Airport to Naples Airport, train
- Fly from Pisa International Airport (PSA) to Naples Airport (NAP)PSA - NAP
- Take the train from Napoli Centrale to Isernia
6h 35m€72–230Train via Rome
- Take the train from Pisa Centrale to Roma TerminiFb / ...
- Take the train from Roma Termini to IserniaRe
6h 4m€28–81Train to Florence Peretola Airport, fly to Fiumicino International Airport, train
- Take the train from Pisa Centrale to Firenze S.M.N.
- Fly from Florence Peretola Airport (FLR) to Fiumicino International Airport (FCO)FLR - FCO
- Take the train from Roma Termini to Isernia
7h 31m€88–248Train to Genoa Cristoforo Colombo Airport, fly to Naples Airport, train
- Take the train from Pisa Centrale to Genova P.Za Principe
- Fly from Genoa Cristoforo Colombo Airport (GOA) to Naples Airport (NAP)GOA - NAP
- Take the train from Napoli Centrale to Isernia
8h 33m€73–267
Pisa to Isernia by train
Questions & Answers
The cheapest way to get from Pisa to Isernia is to bus which costs €3 - €6 and takes 9h 24m.
The fastest way to get from Pisa to Isernia is to drive which takes 4h 58m and costs €75 - €120.
No, there is no direct bus from Pisa to Isernia. However, there are services departing from Pisa and arriving at Isernia via Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 7h 55m.
No, there is no direct train from Pisa to Isernia. However, there are services departing from Pisa Centrale and arriving at Isernia via Roma Tiburtina. The journey, including transfers, takes approximately 5h 23m.
The distance between Pisa and Isernia is 517 km. The road distance is 507.4 km.
The best way to get from Pisa to Isernia without a car is to train which takes 5h 23m and costs €45 - €85.
It takes approximately 5h 23m to get from Pisa to Isernia, including transfers.
Pisa to Isernia bus services, operated by FlixBus, depart from Pisa station.
Pisa to Isernia train services, operated by Trenitalia Frecce, depart from Pisa Centrale station.
The best way to get from Pisa to Isernia is to train which takes 5h 23m and costs €45 - €85. Alternatively, you can bus via Rome, which costs €20 - €60 and takes 7h 55m.
What companies run services between Pisa, Italy and Isernia, Italy?
You can take a train from Pisa Centrale to Isernia via Roma Tiburtina in around 5h 23m. Alternatively, you can take a bus from Pisa to Isernia via Roma, Autostazione Tiburtina in around 7h 55m.
- Website
- ita-airways.com
Flights from Florence Peretola Airport to Fiumicino International Airport
- Ave. Duration
- 55 min
- When
- Every day
- Estimated price
- €55–190
Flights from Genoa Cristoforo Colombo Airport to Naples Airport via Fiumicino International Airport
- Ave. Duration
- 3h 30m
- When
- Every day
- Estimated price
- €60–140
- Website
- ryanair.com
Flights from Pisa International Airport to Naples Airport via Palermo
- Ave. Duration
- 3h 10m
- When
- Friday
- Estimated price
- €65–200
Flights from Pisa International Airport to Naples Airport via Cagliari
- Ave. Duration
- 3h 35m
- When
- Sunday
- Estimated price
- €65–200
Flights from Pisa International Airport to Naples Airport via Tirana
- Ave. Duration
- 3h 40m
- When
- Sunday
- Estimated price
- €65–200
Flights from Pisa International Airport to Naples Airport via Catania
- Ave. Duration
- 3h 45m
- When
- Monday, Friday, and Sunday
- Estimated price
- €65–200
Flights from Genoa Cristoforo Colombo Airport to Naples Airport
- Ave. Duration
- 1h 20m
- When
- Friday and Sunday
- Estimated price
- €50–160
- Website
- easyjet.com
Flights from Pisa International Airport to Naples Airport via Catania
- Ave. Duration
- 4h
- When
- Wednesday and Thursday
- Estimated price
- €65–200
- Website
- volotea.com
Flights from Genoa Cristoforo Colombo Airport to Naples Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €30–140
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Pisa Centrale to Roma Tiburtina
- Ave. Duration
- 2h 9m
- Frequency
- Twice daily
- Estimated price
- €35–65
- Schedules at
- trenitalia.com
Train from Pisa Centrale to Roma Termini
- Ave. Duration
- 2h 56m
- Frequency
- Every 4 hours
- Estimated price
- €29–65
- Schedules at
- trenitalia.com
Train from Pisa Centrale to Genova P.Za Principe
- Ave. Duration
- 2h 2m
- Frequency
- Every 4 hours
- Estimated price
- €17–40
- Schedules at
- trenitalia.com
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Roma Tiburtina to Isernia
- Ave. Duration
- 2h 14m
- Frequency
- 6 times a week
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 3m
- Frequency
- 4 times a day
- Estimated price
- €8–13
- Website
- https://www.trenitalia.com/en.html
Train from Pisa Centrale to Roma Termini
- Ave. Duration
- 4h 5m
- Frequency
- Every 4 hours
- Estimated price
- €16–60
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €11–17
- Website
- https://www.trenitalia.com/en.html
Train from Pisa Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 22m
- Frequency
- Every 30 minutes
- Estimated price
- €16–24
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Pisa Centrale to Roma Termini
- Ave. Duration
- 3h 22m
- Frequency
- Twice daily
- Estimated price
- €16–50
- Website
- https://www.trenitalia.com/en.html
Train from Pisa Centrale to Genova P.Za Principe
- Ave. Duration
- 3h 21m
- Frequency
- Every 4 hours
- Estimated price
- €13–21
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Pisa Centrale to Genova P.Za Principe
- Ave. Duration
- 3h 23m
- Frequency
- Twice a week
- Estimated price
- €40–85
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €60–85
- 2nd Class
- €40–55
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Pisa to Roma, Autostazione Tiburtina
- Ave. Duration
- 4h 45m
- Frequency
- 4 times a day
- Estimated price
- €12–24
- Website
- https://www.flixbus.co.uk
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €12–35
- Website
- https://www.flixbus.co.uk
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Bus from Cassino Piazza Garibaldi to Isernia
- Ave. Duration
- 58 min
- Frequency
- 3 times a day
- Estimated price
- €2–4
- Schedules at
- atm-molise.it
- Phone
- +39 089 233 899
- salerno@autolineecurcio.it
- Website
- autolineecurcio.it
Bus from Pisa to Cassino
- Ave. Duration
- 7h 20m
- Frequency
- Once daily
- Estimated price
- €2
- Website
- https://www.autolineecurcio.it/
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More Questions & Answers
Pisa to Isernia bus services, operated by FlixBus, arrive at Roma, Autostazione Tiburtina station.
Pisa to Isernia train services, operated by Trenitalia Frecce, arrive at Roma Tiburtina station.
Yes, the driving distance between Pisa to Isernia is 507 km. It takes approximately 4h 58m to drive from Pisa to Isernia.
Book your Pisa to Isernia train tickets online with Omio.
Book your Pisa to Isernia bus tickets online with Omio and FlixBus.
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