There are 6 ways to get from Pisa to Cuenca by plane, train, train (Trenitalia, Renfe, Ouigo), bus, car ferry, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Adolfo Suárez Madrid–Barajas Airport, train
best- Fly from Pisa International Airport (PSA) to Adolfo Suárez Madrid–Barajas Airport (MAD)plane PSA - MAD
- Take the train from Madrid Chamartín to Cuenca Fernando Zobeltrain
4h 8m€71–239Train
- Take the train from Pisa Centrale to Firenze S.M.N.train Re
- Take the train from Firenze S.M.N. to Milano Centraletrain Fr
- Take the train from Milano Centrale to Lyon Part Dieutrain Fr
- Take the train from Lyon Part Dieu to Barcelona-Santstrain
- Take the train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandestrain Ave
- Take the train from Madrid-Puerta de Atocha-Almudena Grandes to Cuenca Fernando Zobeltrain Ave
20h 49m€152–334Bus
- Take the bus from Pisa to Genoabus 536 / ...
- Take the bus from Genoa - Via Fanti d'Italia Bus Stop to Barcelona - North Bus Stationbus
- Take the bus from Barcelona, Estació d'Autobusos Nord to Cuencabus 051
26h 40m€112–150Train, car ferry, bus
- Take the train from Pisa Centrale to Genova P.Za Principetrain Fb / ...
- Take the car ferry from Port of Genoa to Port de Barcelonacarferry
- Take the bus from Barcelona, Estació d'Autobusos Nord to Cuencabus 051
34h 13m€130–278Fly to Valencia Airport, train
- Fly from Pisa International Airport (PSA) to Valencia Airport (VLC)plane PSA - VLC
- Take the train from Valencia Joaquin Sorolla to Cuenca Fernando Zobeltrain
4h 16m€72–267Drive 1,545.5 km
- Drive from Pisa to Cuencacar 1,545.5 km
15h 11m€244–352
Pisa to Cuenca by train
Questions & Answers
The cheapest way to get from Pisa to Cuenca is to fly and train which costs €70 - €240 and takes 4h 8m.
The fastest way to get from Pisa to Cuenca is to fly and train which takes 4h 8m and costs €70 - €240.
No, there is no direct bus from Pisa to Cuenca. However, there are services departing from Pisa and arriving at Cuenca via Genoa - Via Fanti d'Italia Bus Stop and Barcelona, Estació d'Autobusos Nord. The journey, including transfers, takes approximately 26h 40m.
No, there is no direct train from Pisa to Cuenca. However, there are services departing from Pisa Centrale and arriving at Cuenca Fernando Zobel via Firenze S.M.N., Milano Centrale, Lyon Part Dieu, Barcelona-Sants and Madrid-Puerta de Atocha-Almudena Grandes. The journey, including transfers, takes approximately 20h 49m.
The distance between Pisa and Cuenca is 1412 km. The road distance is 1545.5 km.
The best way to get from Pisa to Cuenca without a car is to train which takes 20h 49m and costs €150 - €340.
It takes approximately 4h 8m to get from Pisa to Cuenca, including transfers.
Pisa to Cuenca bus services, operated by FlixBus, depart from Pisa station.
Pisa to Cuenca train services, operated by Trenitalia, depart from Pisa Centrale station.
The best way to get from Pisa to Cuenca is to train which takes 20h 49m and costs €150 - €340. Alternatively, you can bus, which costs €110 - €150 and takes 26h 40m.
What companies run services between Pisa, Italy and Cuenca, Spain?
You can take a train from Pisa Centrale to Cuenca Fernando Zobel via Firenze S.M.N., Milano Centrale, Lyon Part Dieu, Barcelona-Sants, and Madrid-Puerta de Atocha-Almudena Grandes in around 20h 49m. Alternatively, you can take a bus from Pisa to Cuenca via Genoa, Genoa - Via Fanti d'Italia Bus Stop, and Barcelona, Estació d'Autobusos Nord in around 26h 40m.
- Website
- ryanair.com
Flights from Pisa International Airport to Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 2h 10m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €55–180
Flights from Pisa International Airport to Valencia Airport
- Ave. Duration
- 1h 55m
- When
- Every day
- Estimated price
- €55–190
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Madrid Chamartín to Cuenca Fernando Zobel
- Ave. Duration
- 1h 3m
- Frequency
- Every 2 hours
- Estimated price
- €27–40
- Website
- https://www.renfe.com/es/en
- Básico
- €27–40
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 2m
- Frequency
- Hourly
- Estimated price
- €50–75
- Website
- https://www.renfe.com/es/en
- Básico
- €50–75
Train from Madrid-Puerta de Atocha-Almudena Grandes to Cuenca Fernando Zobel
- Ave. Duration
- 57 min
- Frequency
- Every 4 hours
- Estimated price
- €26–40
- Website
- https://www.renfe.com/es/en
- Básico
- €26–40
Train from Valencia Joaquin Sorolla to Cuenca Fernando Zobel
- Ave. Duration
- 1h 1m
- Frequency
- Every 3 hours
- Estimated price
- €27–40
- Website
- https://www.renfe.com/es/en
- Básico
- €27–40
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Madrid Chamartín to Cuenca Fernando Zobel
- Ave. Duration
- 1h 10m
- Frequency
- Every 2 hours
- Estimated price
- €17–23
- Website
- https://www.renfe.com/es/en
Train from Lyon Part Dieu to Barcelona-Sants
- Ave. Duration
- 4h 48m
- Frequency
- Once daily
- Estimated price
- €50–75
- Website
- https://www.renfe.com/es/en
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 28m
- Frequency
- Twice daily
- Estimated price
- €45–65
- Website
- https://www.renfe.com/es/en
Train from Madrid-Puerta de Atocha-Almudena Grandes to Cuenca Fernando Zobel
- Ave. Duration
- 1h 24m
- Frequency
- Once daily
- Estimated price
- €16–22
- Website
- https://www.renfe.com/es/en
Train from Valencia Joaquin Sorolla to Cuenca Fernando Zobel
- Ave. Duration
- 1h 1m
- Frequency
- 4 times a day
- Estimated price
- €17–24
- Website
- https://www.renfe.com/es/en
- Phone
- +34 900 926 851
- atencion.cliente@iryo.eu
- Website
- iryo.eu
Train from Madrid Chamartín to Cuenca Fernando Zobel
- Ave. Duration
- 1h 2m
- Frequency
- 3 times a day
- Estimated price
- €16–45
- Website
- https://iryo.eu/en/home
- Inicial
- €16–45
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 17m
- Frequency
- Hourly
- Estimated price
- €27–85
- Website
- https://iryo.eu/en/home
- Inicial
- €27–85
Train from Valencia Joaquin Sorolla to Cuenca Fernando Zobel
- Ave. Duration
- 55 min
- Frequency
- Once daily
- Estimated price
- €17–50
- Website
- https://iryo.eu/en/home
- Inicial
- €17–50
- Phone
- +34 910 780 990
- Website
- ouigo.com
Train from Madrid Chamartín to Cuenca Fernando Zobel
- Ave. Duration
- 1h 3m
- Frequency
- 3 times a day
- Estimated price
- €11–25
- Website
- https://www.ouigo.com/es/en
Train from Barcelona-Sants to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 3h 17m
- Frequency
- 5 times a day
- Estimated price
- €25–80
- Website
- https://www.ouigo.com/es/en
Train from Valencia Joaquin Sorolla to Cuenca Fernando Zobel
- Ave. Duration
- 55 min
- Frequency
- Once daily
- Estimated price
- €11–26
- Website
- https://www.ouigo.com/es/en
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Pisa Centrale to Firenze S.M.N.
- Ave. Duration
- 1h 25m
- Frequency
- Every 30 minutes
- Estimated price
- €6–9
- Website
- https://www.trenitalia.com/en.html
Train from Milano Centrale to Lyon Part Dieu
- Ave. Duration
- 4h 47m
- Frequency
- Twice daily
- Estimated price
- €25–40
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Firenze S.M.N. to Milano Centrale
- Ave. Duration
- 1h 55m
- Frequency
- Hourly
- Estimated price
- €40–85
- Schedules at
- trenitalia.com
Train from Pisa Centrale to Genova P.Za Principe
- Ave. Duration
- 2h 5m
- Frequency
- Every 4 hours
- Estimated price
- €23–45
- Schedules at
- trenitalia.com
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Firenze S.M.N. to Milano Centrale
- Ave. Duration
- 3h 54m
- Frequency
- Once daily
- Estimated price
- €30–70
- Website
- https://www.trenitalia.com/en.html
Train from Pisa Centrale to Genova P.Za Principe
- Ave. Duration
- 3h 21m
- Frequency
- Every 4 hours
- Estimated price
- €16–40
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Pisa Centrale to Genova P.Za Principe
- Ave. Duration
- 3h 23m
- Frequency
- Twice a week
- Estimated price
- €40–85
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €60–85
- 2nd Class
- €40–55
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Pisa to Genoa
- Ave. Duration
- 3h 15m
- Frequency
- 4 times a day
- Estimated price
- €11–19
- Website
- https://www.flixbus.co.uk
- Phone
- +3-389-268-0068
- Website
- blablacar.co.uk
Bus from Genoa - Via Fanti d'Italia Bus Stop to Barcelona - North Bus Station
- Ave. Duration
- 12h 55m
- Frequency
- 3 times a day
- Estimated price
- €55–80
- Website
- https://www.blablacar.co.uk/bus
- Phone
- +34 984 689 912
- atencionalusuario@samar.es
- Website
- samar.es
Bus from Barcelona, Estació d'Autobusos Nord to Cuenca
- Ave. Duration
- 8h 30m
- Frequency
- 5 times a week
- Estimated price
- €46–51
- Schedules at
- samar.es
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Genoa to Port de Barcelona
- Ave. Duration
- 20h 45m
- Frequency
- Twice a week
- Estimated price
- €65–140
- Website
- https://www.gnv.it/en
- Seat
- €65–95
- Cabin
- €120–140
Want to know more about travelling around Spain
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Train travel in Spain: A guide to Renfe
Read the travel guide
What are the different types of Renfe trains in Spain?
Read the travel guide
5 incredible day trips from Florence by train
Read the travel guide
More Questions & Answers
Pisa to Cuenca bus services, operated by FlixBus, arrive at Genoa station.
Pisa to Cuenca train services, operated by Trenitalia, arrive at Firenze S.M.N. station.
Yes, the driving distance between Pisa to Cuenca is 1545 km. It takes approximately 15h 11m to drive from Pisa to Cuenca.
Book your Pisa to Cuenca train tickets online with Omio.
Book your Pisa to Cuenca bus tickets online with Omio.
There are 347+ hotels available in Cuenca.


















































