Trenitalia operates a train from Pisa Airport (PSA) to Signa hourly. Tickets cost $4 - $21 and the journey takes 42 min. Ataf&Linea also services this route every 30 minutes. Alternatively, Autostradale operates a bus from Pisa Airport (PSA) to Signa hourly. Tickets cost $8 - $18 and the journey takes 1 h 10 min. Blubus also services this route hourly.
From Pisa Centrale train to Lastra A Signa Rimaggio then line 72 bus to Signa La Pira. 1 h 17 min 7€. From Pisa Airport bus to P.Za Stazione then bus to Vingone 70. 2 h 8 min 12€. From Pisa Airport (PSA) taxi to Signa. 1 h 199€. From Pisa Airport (PSA) drive to Signa. 1 h 11€.