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How to get fromPhiladelphia to St. Louisby plane, bus (Greyhound), train (Amtrak), car, or train

Find Transport to St. Louis

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There are 8 ways to get from Philadelphia to St. Louis by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Philadelphia International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    4h 24m
    $156–806

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Philadelphia Bus Station to St Louis Bus Stationbus bus Greyhound US0421
    20h 50m
    $130–260

  3. Train (Amtrak)

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    26h 46m
    $348–1,326

  4. Drive 881.7 mi

    1. Drive from Philadelphia to St. Louiscar car 881.7 mi
    15h 1m
    $161–233

  5. Train to Baltimore-Washington International Airport, fly

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    5h 26m
    $157–1,261

  6. Train to Newark Liberty International Airport, fly

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    5h 29m
    $398–855

  7. Train to Ronald Reagan Washington National Airport, fly

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)plane plane DCA - STL
    6h 16m
    $198–1,023

  8. Train to Laguardia Airport, fly

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    6h 43m
    $172–1,056

Philadelphia to St. Louis by bus (Greyhound)

Calendar42Weekly Buses
Duration20h 50mAverage Duration
Ticket$130Cheapest Price
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Comparing Your Travel Options

Map of how to get from Philadelphia to St. Louis.ExpandLaunch map view
  • Distance: 833.7 mi
  • Duration: 4h 24m

What companies run services between Philadelphia, PA, USA and St. Louis, MO, USA?

American Airlines, Southwest Airlines, and Delta fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, Greyhound USA operates a bus from Philadelphia Bus Station to St Louis Bus Station every 4 hours. Tickets cost $130–260 and the journey takes 20h 50m.

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