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How to get fromPhiladelphia to St. Louisby plane, bus (Greyhound), train (Amtrak), car or train

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There are 10 ways to get from Philadelphia to St. Louis by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Philadelphia International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)plane plane PHL - STL
    4h 44m
    $216–493

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Philadelphia to St Louis Bus Stationbus bus Greyhound US0421
    20h 30m
    $90–250

  3. Train via Washington (Amtrak)

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    26h 38m
    $155–1,099

  4. Drive 881.7 mi

    1. Drive from Philadelphia to St. Louiscar car 881.7 mi
    14h 57m
    $161–233

  5. Train to Baltimore-Washington International Airport, fly

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain train
    2. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)plane plane BWI - STL
    5h 46m
    $223–1,071

  6. Train to Newark Liberty International Airport, fly

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain train
    2. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)plane plane EWR - STL
    5h 56m
    $253–702

  7. Train to John F. Kennedy International Airport, fly

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from John F. Kennedy International Airport (JFK) to Lambert–St. Louis International Airport (STL)plane plane JFK - STL
    6h 28m
    $149–1,268

  8. Train to Ronald Reagan Washington National Airport, fly

    1. Take the train from 30th Street Station to Washington Union Stationtrain train
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)plane plane DCA - STL
    6h 36m
    $235–1,843

  9. Train to Laguardia Airport, fly

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain train
    2. Fly from Laguardia Airport (LGA) to Lambert–St. Louis International Airport (STL)plane plane LGA - STL
    7h 17m
    $222–1,065

  10. Train (Amtrak)

    1. Take the train from 30th Street Station to Chicago Union Stationtrain train Cardinal
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    32h 31m
    $153–597

Philadelphia to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration20h 30mAverage Duration
Ticket$90Cheapest Price
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Questions & Answers

What companies run services between Philadelphia, PA, USA and St. Louis, MO, USA?

American Airlines, Southwest Airlines, and Delta fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, Greyhound USA operates a bus from Philadelphia to St Louis Bus Station 3 times a day. Tickets cost $90–250 and the journey takes 20h 30m.

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