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How to get fromPhiladelphia to St. Louisby plane, bus (Greyhound), train (Amtrak), car or train

Find Transport to St. Louis

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There are 9 ways to get from Philadelphia to St. Louis by plane, bus (Greyhound), train (Amtrak), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Philadelphia International Airport

    best
    1. Fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL)planePHL - STL
    4h 39m
    $199–493

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Philadelphia to St Louis Bus StationbusGreyhound US0421
    20h 30m
    $100–240

  3. Train via Washington (Amtrak)

    1. Take the train from 30th Street Station to Washington Union Stationtrain
    2. Take the train from Rockville Amtrak to Chicago Union Stationtrain
    3. Take the train from Chicago Union Station to St. Louistrain
    26h 38m
    $171–1,229

  4. Drive 881.7 mi

    1. Drive from Philadelphia to St. Louiscar881.7 mi
    14h 48m
    $161–233

  5. Train to Baltimore-Washington International Airport, fly

    1. Take the train from 30th Street Station to BWI Thurgood Marshalltrain
    2. Fly from Baltimore-Washington International Airport (BWI) to Lambert–St. Louis International Airport (STL)planeBWI - STL
    5h 36m
    $228–1,031

  6. Train to Newark Liberty International Airport, fly

    1. Take the train from 30th Street Station to Newark Liberty International Airporttrain
    2. Fly from Newark Liberty International Airport (EWR) to Lambert–St. Louis International Airport (STL)planeEWR - STL
    5h 43m
    $153–772

  7. Train to Ronald Reagan Washington National Airport, fly

    1. Take the train from 30th Street Station to Washington Union Stationtrain
    2. Fly from Ronald Reagan Washington National Airport (DCA) to Lambert–St. Louis International Airport (STL)planeDCA - STL
    6h 26m
    $226–1,743

  8. Train to John F. Kennedy International Airport, fly

    1. Take the train from 30th Street Station to Ny Moynihan Train Hall At Penn Stationtrain
    2. Fly from John F. Kennedy International Airport (JFK) to Lambert–St. Louis International Airport (STL)planeJFK - STL
    6h 45m
    $149–1,218

  9. Train (Amtrak)

    1. Take the train from 30th Street Station to Chicago Union StationtrainCardinal
    2. Take the train from Chicago Union Station to St. LouistrainLincoln Service / ...
    32h 31m
    $179–810

Philadelphia to St. Louis by bus (Greyhound)

Calendar21Weekly Buses
Duration20h 30mAverage Duration
Ticket$100Cheapest Price
See schedules

Questions & Answers

What companies run services between Philadelphia, PA, USA and St. Louis, MO, USA?

American Airlines, Southwest Airlines, and Delta fly from Philadelphia International Airport (PHL) to Lambert–St. Louis International Airport (STL) every 3 hours. Alternatively, Greyhound USA operates a bus from Philadelphia to St Louis Bus Station 3 times a day. Tickets cost $100–240 and the journey takes 20h 30m.

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