There are 8 ways to get from Perryville to Chicago by taxi, plane, train, car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi to Cape Girardeau Municipal Airport, fly to Chicago O'Hare International Airport
best- Take the taxi from Perryville to Cape Girardeau Municipal Airport (CGI)
- Fly from Cape Girardeau Municipal Airport (CGI) to Chicago O'Hare International Airport (ORD)CGI - ORD
3h 11m$165–291Drive 350.9 mi
cheapest- Drive from Perryville to Chicago350.9 mi
6h 32m$64–93Taxi, train (Amtrak)
- Take the taxi from Perryville to Carbondale
- Take the train from Carbondale to Chicago Union StationSaluki / ...
6h 47m$161–258Drive, bus
- Drive from Perryville to Anna - Shell
- Take the bus from Anna - Shell to ChicagoQuerétaro
8h 16m$88–206Taxi to Williamson County Regional Airport, fly to Chicago O'Hare International Airport
- Take the taxi from Perryville to Williamson County Regional Airport (MWA)
- Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)MWA - ORD
3h 55m$208–348Drive to Barkley Regional Airport, fly to Chicago O'Hare International Airport
- Drive from Perryville to Barkley Regional Airport (PAH)
- Fly from Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD)PAH - ORD
4h 42m$260–1,731Taxi, bus to Lambert–St. Louis International Airport, fly to Chicago Midway International Airport
- Take the taxi from Perryville to Cape Girardeau
- Take the bus from Cape Girardeau to St Louis Bus Station
- Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)STL - MDW
5h 59m$179–616Taxi, bus (Flixbus)
- Take the taxi from Perryville to Carbondale Intermodal Station
- Take the bus from Carbondale Intermodal Station to Chicago Bus StationFlixBus N2521
10h 47m$171–247
Cape Girardeau Municipal Airport (CGI) to Chicago O'Hare International Airport (ORD) flights
Questions & Answers
The cheapest way to get from Perryville to Chicago is to drive which costs $60 - $95 and takes 6h 32m.
The fastest way to get from Perryville to Chicago is to taxi and fly which takes 3h 11m and costs $160 - $300.
The distance between Perryville and Chicago is 402 miles. The road distance is 353 miles.
The best way to get from Perryville to Chicago without a car is to taxi and train which takes 6h 47m and costs $160 - $260.
It takes approximately 3h 11m to get from Perryville to Chicago, including transfers.
Yes, the driving distance between Perryville to Chicago is 353 miles. It takes approximately 6h 32m to drive from Perryville to Chicago.
There are 1245+ hotels available in Chicago.
What companies run services between Perryville, MO, USA and Chicago, IL, USA?
There is no direct connection from Perryville to Chicago. However, you can take the taxi to Cape Girardeau Municipal Airport (CGI) airport, fly to Chicago O'Hare International Airport (ORD), walk to O'Hare, then take the subway to Jackson-Blue. Alternatively, you can take the taxi to Carbondale then take the train to Chicago Union Station.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 8m
- When
- Every day
- Estimated price
- $70–480
- Website
- contouraviation.com
Flights from Cape Girardeau Municipal Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $65–170
Flights from Williamson County Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $60–170
- Website
- united.com
Flights from Barkley Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 45m
- When
- Monday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $80–550
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Carbondale to Chicago Union Station
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $45–120
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- tornadobus.com
Bus from Anna - Shell to Chicago
- Ave. Duration
- 6h 20m
- Frequency
- Once daily
- Estimated price
- $70–180
- Schedules at
- tornadobus.com
- Adults 11-59
- $70–180
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Cape Girardeau to St Louis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $21–30
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Carbondale Intermodal Station to Chicago Bus Station
- Ave. Duration
- 9h 30m
- Frequency
- Once daily
- Estimated price
- $55–110
- Schedules at
- flixbus.com
- Ave. Duration
- 1h 6m
- Estimated price
- $80–180
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide









