How to get fromPanama to Cuencaby plane, taxi, bus or car

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There are 5 ways to get from Panama to Cuenca by plane, taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly to José Joaquín De Olmedo International Airport, taxi
best
1. Fly from Tocumen International Airport (PTY) to José Joaquín De Olmedo International Airport (GYE)plane PTY - GYE
2. Take the taxi from Guayaquil-Airport-GYE to Cuencataxi
7h 46m
$390–670
Fly to Santa Rosa Regional Airport, bus
cheapest
1. Fly from Tocumen International Airport (PTY) to Santa Rosa Regional Airport (ETR)plane PTY - ETR
2. Take the bus from Santa Rosa to Cuencabus
9h 55m
$141–470
Fly to Cuenca
1. Fly from Tocumen International Airport (PTY) to Cuenca (CUE)plane PTY - CUE
6h 29m
$260–440
Fly to Eloy Alfaro International Airport, bus
1. Fly from Tocumen International Airport (PTY) to Eloy Alfaro International Airport (MEC)plane PTY - MEC
2. Take the bus from Manta to Terminal Terrestre de Guayaquilbus
3. Take the bus from Terminal Terrestre de Guayaquil to Cuencabus
12h 16m
$304–570
Fly to Mariscal Sucre International Airport, car, bus
1. Fly from Tocumen International Airport (PTY) to Mariscal Sucre International Airport (UIO)plane PTY - UIO
2. Drive from Quito Airport to Quitocar
3. Take the bus from Quito to Terminal Terrestre de Ambatobus
4. Take the bus from Ambato to Cuencabus
12h 40m
$258–785

Tocumen International Airport (PTY) to José Joaquín De Olmedo International Airport (GYE) flights

54Weekly Planes

2h 46mAverage Duration

$72Cheapest Price

Questions & Answers

Map of how to get from Panama to Cuenca.

Launch map view

Distance: 1,461.5 km
Duration: 7h 46m

What companies run services between Panama and Cuenca, Ecuador?

Copa Airlines, LATAM Chile, and Avianca - Aerovías del Continente Americano S.A. fly from Tocumen International Airport (PTY) to Cuenca (CUE) 3 times a day.

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Cuenca(opens in a new window), Ecuador(opens in a new window)

Cuenca, officially Santa Ana de los Ríos de Cuenca, is an Ecuadorian city, head of the canton of the same name and capital of the province of Azuay, as well as its largest and most populated city. It is crossed by the Tomebamba, Tarqui, Yanuncay and Machángara rivers, in the south-central inter-Andean region of Ecuador, in the Paute river basin, at an altitude of 2,538 meters above sea level and with a temperate Andean climate averaging 16.3 °C.

Things to do in Cuenca

New Cathedral of Cuenca(Opens in a new window)

The Cathedral of the Immaculate Conception (Spanish: Catedral de la Inmaculada Concepción), commonly referred to as the New Cathedral of Cuenca (Spanish: Nueva Catedral de Cuenca), is the cathedral church in Cuenca, Ecuador. It is situated in front of Parque Calderon.

Old Cathedral of Cuenca(Opens in a new window)

The Church of the Shrine (Spanish: Iglesia del Sagrario) — commonly referred to as the Old Cathedral of Cuenca (Spanish: Catedral Vieja de Cuenca) — was the main place of Spanish worship during the time of Spanish colonization in Cuenca, Ecuador. It functions today as the Museum for Religious Art and is located at the Parque Calderon, opposite the New Cathedral.

Places to stay in Cuenca

$98

Mansión Alcázar Boutique Hotel(Opens in a new window)

9.6Exceptional

$58

Santa Lucia House - Forum(Opens in a new window)

9.4Superb

$126

Hotel Boutique Santa Lucia(Opens in a new window)

9.2Superb

$66

Hotel Boutique Los Balcones(Opens in a new window)

9.2Superb

Rome2Rio makes travelling from Panama to Cuenca easy.

Rome2Rio is a door-to-door travel information and booking engine, helping you get to and from any location in the world. Find all the transport options for your trip from Panama to Cuenca right here. Rome2Rio displays up to date schedules, route maps, journey times and estimated fares from relevant transport operators, ensuring you can make an informed decision about which option will suit you best. Rome2Rio also offers online bookings for selected operators, making reservations easy and straightforward.