How to get fromPanama City to Cuencaby plane, taxi, bus or car

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There are 5 ways to get from Panama City to Cuenca by plane, taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly to José Joaquín De Olmedo International Airport, taxi
best
1. Fly from Tocumen International Airport (PTY) to José Joaquín De Olmedo International Airport (GYE)plane PTY - GYE
2. Take the taxi from Guayaquil-Airport-GYE to Cuencataxi
7h 43m
$308–778
Fly to Cuenca
cheapest
1. Fly from Tocumen International Airport (PTY) to Cuenca (CUE)plane PTY - CUE
6h 29m
$98–368
Fly to Eloy Alfaro International Airport, bus
1. Fly from Tocumen International Airport (PTY) to Eloy Alfaro International Airport (MEC)plane PTY - MEC
2. Take the bus from Manta to Terminal Terrestre de Guayaquilbus
3. Take the bus from Terminal Terrestre de Guayaquil to Cuencabus
12h 12m
$242–587
Fly to Mariscal Sucre International Airport, car, bus
1. Fly from Tocumen International Airport (PTY) to Mariscal Sucre International Airport (UIO)plane PTY - UIO
2. Drive from Quito Airport to Quitocar
3. Take the bus from Quito to Terminal Terrestre de Ambatobus
4. Take the bus from Ambato to Cuencabus
12h 31m
$216–493
Fly to Santa Rosa Regional Airport, bus
1. Fly from Tocumen International Airport (PTY) to Santa Rosa Regional Airport (ETR)plane PTY - ETR
2. Take the bus from Santa Rosa to Cuencabus
12h 42m
$159–568

Tocumen International Airport (PTY) to José Joaquín De Olmedo International Airport (GYE) flights

44Weekly Planes

2h 53mAverage Duration

$68Cheapest Price

Questions & Answers

Map of how to get from Panama City to Cuenca.

Launch map view

Distance: 1,463.3 km
Duration: 7h 43m

What companies run services between Panama City, Panama and Cuenca, Ecuador?

Copa Airlines, LATAM Chile, and Avianca - Aerovías del Continente Americano S.A. fly from Tocumen International Airport (PTY) to Cuenca (CUE) twice daily.

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Cuenca(opens in a new window), Ecuador(opens in a new window)

Cuenca, officially Santa Ana de los Ríos de Cuenca, is an Ecuadorian city, head of the canton of the same name and capital of the province of Azuay, as well as its largest and most populated city. It is crossed by the Tomebamba, Tarqui, Yanuncay and Machángara rivers, in the south-central inter-Andean region of Ecuador, in the Paute river basin, at an altitude of 2,538 meters above sea level and with a temperate Andean climate averaging 16.3 °C.

Things to do in Cuenca

New Cathedral of Cuenca(Opens in a new window)

The Cathedral of the Immaculate Conception (Spanish: Catedral de la Inmaculada Concepción), commonly referred to as the New Cathedral of Cuenca (Spanish: Nueva Catedral de Cuenca), is the cathedral church in Cuenca, Ecuador. It is situated in front of Parque Calderon.

Old Cathedral of Cuenca(Opens in a new window)

The Church of the Shrine (Spanish: Iglesia del Sagrario) — commonly referred to as the Old Cathedral of Cuenca (Spanish: Catedral Vieja de Cuenca) — was the main place of Spanish worship during the time of Spanish colonization in Cuenca, Ecuador. It functions today as the Museum for Religious Art and is located at the Parque Calderon, opposite the New Cathedral.

Places to stay in Cuenca

TRYP by Wyndham Cuenca Zahir(Opens in a new window)

8.8Fabulous

Mansion Alcazar(Opens in a new window)

9.0Fabulous

Four Points by Sheraton Cuenca(Opens in a new window)

9.1Superb

Villa Emilia Hostal(Opens in a new window)

9.6Exceptional

Rome2Rio makes travelling from Panama City to Cuenca easy.

Rome2Rio is a door-to-door travel information and booking engine, helping you get to and from any location in the world. Find all the transport options for your trip from Panama City to Cuenca right here. Rome2Rio displays up to date schedules, route maps, journey times and estimated fares from relevant transport operators, ensuring you can make an informed decision about which option will suit you best. Rome2Rio also offers online bookings for selected operators, making reservations easy and straightforward.