There are 3 ways to get from Panama City to Indianapolis by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  5 h 30 min

  1. Fly from Panama City (ECP) to Indianapolis (IND) ECP - IND

$213 - $874

Cheapest option

Bus  •  24 h 52 min

  1. Take the bus from Panama City, Fl to Tallahassee, Fl
  2. Take the bus from Tallahassee, Fl to Louisville, Ky
  3. Take the bus from Louisville, KY to Indianapolis, IN - Amtrak

$109 - $246

1 alternative option

Drive  •  13 h 15 min

  1. Drive from Panama City to Indianapolis 757.7 miles

$70 - $110

Questions & Answers

The cheapest way to get from Panama City to Indianapolis is to drive which costs $70 - $110 and takes 13 h 15 min.

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The quickest way to get from Panama City to Indianapolis is to fly which costs $210 - $900 and takes 5 h 30 min.

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No, there is no direct bus from Panama City to Indianapolis. However, there are services departing from Panama City, Fl and arriving at Indianapolis, IN - Amtrak via Tallahassee, Fl and Louisville, KY. The journey, including transfers, takes approximately 24 h 52 min.

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The distance between Panama City and Indianapolis is 668 miles. The road distance is 757.7 miles.

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The best way to get from Panama City to Indianapolis without a car is to bus which takes 24 h 52 min and costs $100 - $250.

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It takes approximately 5 h 30 min to get from Panama City to Indianapolis, including transfers.

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Panama City to Indianapolis bus services, operated by Greyhound USA, depart from Panama City, Fl station.

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The best way to get from Panama City to Indianapolis is to fly which takes 5 h 30 min and costs $210 - $900. Alternatively, you can bus, which costs $100 - $250 and takes 24 h 52 min.

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There is no direct flight from Panama City Airport to Indianapolis Airport. The quickest flight takes 3 h 51 min and has one stopover.

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Panama City to Indianapolis bus services, operated by Amtrak, arrive at Indianapolis, IN - Amtrak station.

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Map of how to get from Panama City to Indianapolis.
Launch map view
  • Distance: 668.4 miles
  • Duration: 5 h 30 min

What companies run services between Panama City, FL, USA and Indianapolis, IN, USA?

Delta, American Airlines and two other airlines fly from Panama City to Indianapolis hourly. Alternatively, you can take a bus from Panama City to Indianapolis via Tallahassee, Fl, Louisville, Ky, and Louisville, KY in around 24 h 52 min.

Airlines
Delta
Website
delta.com
Flights from Panama City to Indianapolis via Atlanta
Ave. Duration
4 h 35 min
When
Every day
Estimated price
$150 - $800
Southwest Airlines
Website
southwest.com
Flights from Panama City to Indianapolis via Dallas
Ave. Duration
7 h 8 min
When
Every day
Estimated price
$250 - $950
Flights from Panama City to Indianapolis via Houston Hobby Apt
Ave. Duration
8 h 15 min
When
Saturday and Sunday
Estimated price
$250 - $950
American Airlines
Website
aa.com
Flights from Panama City to Indianapolis via Charlotte
Ave. Duration
6 h 46 min
When
Every day
Estimated price
$180 - $850
Flights from Panama City to Indianapolis via Dallas/Ft.Worth
Ave. Duration
7 h 55 min
When
Every day
Estimated price
$220 - $900
United Airlines
Website
united.com
Flights from Panama City to Indianapolis via Houston
Ave. Duration
7 h 57 min
When
Every day
Estimated price
$220 - $1,000
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Panama City, Fl to Tallahassee, Fl
Ave. Duration
3 h 15 min
Frequency
Every 30 minutes
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $24
Flexible
$28 - $40
Bus from Tallahassee, Fl to Louisville, Ky
Ave. Duration
17 h 45 min
Frequency
Hourly
Estimated price
$65 - $170
Website
greyhound.com
Economy
$65 - $110
Flexible
$130 - $170
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Bus from Louisville, KY to Indianapolis, IN - Amtrak
Ave. Duration
2 h 10 min
Frequency
Twice daily
Website
amtrak.com

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More Questions & Answers

Indianapolis is 1 h ahead of Panama City. It is currently 2:23 AM in Panama City and 3:23 AM in Indianapolis.

Yes, the driving distance between Panama City to Indianapolis is 758 miles. It takes approximately 13 h 15 min to drive from Panama City to Indianapolis.

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United Airlines, American Airlines, Delta and Southwest Airlines offer flights from Panama City Airport to Indianapolis Airport.

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There are 243+ hotels available in Indianapolis. Prices start at $69 USD per night.

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The best way to get from Panama City to Panama City Airport is to taxi which takes 35 min and costs $60 - $75.

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