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There are 5 ways to get from Panama City to Guatemala City by plane, bus, night bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly  •  6 h 43 min

  1. Fly from Panama City (ECP) to Guatemala City (GUA) ECP - GUA

$282 - $1,373

Cheapest option

Bus, night bus  •  2 days 20 h

  1. Take the bus from Panama City, Fl to Houston, Tx
  2. Take the night bus from Houston, Tx to San Antonio, Tx
  3. Take the night bus from San Antonio, Tx to Brownsville, Tx
  4. Take the bus from Matamoros to Tapachula
  5. Take the bus from Tapachula, Mexico to Guatemala City Terminal Transgalgos Internacional

$222 - $541

3 alternative options

Bus, train, drive  •  2 days 20 h

  1. Take the bus from Panama City, Fl to Lafayette, La
  2. Take the train from Lafayette Amtrak Station to San Antonio Amtrak Station
  3. Take the bus from San Antonio, Tx to Raymondville, Tx 897 / ...
  4. Drive from Raymondville, Tx to Matamoros
  5. Take the bus from Matamoros to Tapachula
  6. Take the bus from Malacatán to Guatemala City

$231 - $536

Bus  •  2 days 23 h

  1. Take the bus from Panama City, Fl to Houston, Tx
  2. Take the bus from Houston, Tx to San Antonio, Tx
  3. Take the bus from San Antonio to Matamoros
  4. Take the bus from Matamoros to Tapachula
  5. Take the bus from Tapachula, Mexico to Guatemala City Terminal Transgalgos Internacional

$233 - $486

Drive  •  46 h 5 min

  1. Drive from Panama City to Guatemala City 2325.2 miles

$260 - $390

Questions & Answers

The cheapest way to get from Panama City to Guatemala City is to drive which costs $260 - $390 and takes 46 h 5 min.

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The quickest way to get from Panama City to Guatemala City is to fly which costs $280 - $1,400 and takes 6 h 43 min.

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No, there is no direct bus from Panama City to Guatemala City. However, there are services departing from Panama City, Fl and arriving at Guatemala City Terminal Transgalgos Internacional via Houston, Tx, San Antonio, Tx, Brownsville, TX, Matamoros and Tapachula, Mexico. The journey, including transfers, takes approximately 2 days 20 h.

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The distance between Panama City and Guatemala City is 1122 miles. The road distance is 2325.2 miles.

Get driving directions

The best way to get from Panama City to Guatemala City without a car is to bus and night bus which takes 2 days 20 h and costs $220 - $550.

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It takes approximately 6 h 43 min to get from Panama City to Guatemala City, including transfers.

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Panama City to Guatemala City bus services, operated by Greyhound USA, depart from Panama City, Fl station.

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The best way to get from Panama City to Guatemala City is to fly which takes 6 h 43 min and costs $280 - $1,400. Alternatively, you can bus, which costs $230 - $490 and takes 2 days 23 h.

Mode details

There is no direct flight from Panama City Airport to Guatemala City Airport. The quickest flight takes 5 h 29 min and has one stopover.

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Panama City to Guatemala City bus services, operated by Trans Galgos Inter, arrive at Guatemala City Terminal Transgalgos Internacional station.

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Map of how to get from Panama City to Guatemala City.
Launch map view
  • Distance: 1122.3 miles
  • Duration: 6 h 43 min

What companies run services between Panama City, FL, USA and Guatemala City, Guatemala?

Delta and United Airlines fly from Panama City to Guatemala City every 4 hours. Alternatively, you can take a bus from Panama City to Guatemala City via Houston, Tx, San Antonio, Tx, San Antonio, Matamoros, and Tapachula, Mexico in around 2 days 23 h.

Airlines
Delta
Website
delta.com
Flights from Panama City to Guatemala City via Atlanta
Ave. Duration
5 h 50 min
When
Every day
Estimated price
$230 - $1,500
United Airlines
Website
united.com
Flights from Panama City to Guatemala City via Houston
Ave. Duration
6 h 52 min
When
Every day
Estimated price
$220 - $1,300
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Lafayette Amtrak Station to San Antonio Amtrak Station
Ave. Duration
11 h 41 min
Frequency
3 times a week
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$120 - $170
Business Coach Seat
$130 - $180
Room
$290 - $410
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Panama City, Fl to Houston, Tx
Ave. Duration
16 h 20 min
Frequency
Every 3 hours
Estimated price
$60 - $160
Website
greyhound.com
Economy
$60 - $110
Flexible
$120 - $160
Night bus from Houston, Tx to San Antonio, Tx
Ave. Duration
3 h 15 min
Frequency
4 times a day
Estimated price
$24 - $60
Website
greyhound.com
Economy
$24 - $40
Flexible
$45 - $60
Night bus from San Antonio, Tx to Brownsville, Tx
Ave. Duration
5 h 40 min
Frequency
Once daily
Estimated price
$30 - $80
Website
greyhound.com
Economy
$30 - $55
Flexible
$60 - $80
Bus from Panama City, Fl to Lafayette, La
Ave. Duration
10 h 40 min
Frequency
5 times a day
Estimated price
$40 - $110
Website
greyhound.com
Economy
$40 - $70
Flexible
$80 - $110
Bus from San Antonio, Tx to Raymondville, Tx
Ave. Duration
4 h 45 min
Frequency
Every 4 hours
Estimated price
$28 - $70
Website
greyhound.com
Economy
$28 - $45
Flexible
$50 - $70
ADO
Phone
+52 800 369 4652
Website
ado.com.mx
Bus from Matamoros to Tapachula
Ave. Duration
30 h 45 min
Frequency
Once daily
Estimated price
$70 - $150
Schedules at
ado.com.mx
First
$75 - $110
Economy
$70 - $110
Trans Galgos Inter
Autobuses FDN
Phone
+502 79477070, +502 22513817, Whatsapp: +502 47397438
Email
info@transportesfuentedelnorte.com
Website
facebook.com
Bus from Malacatán to Guatemala City
Ave. Duration
4 h 30 min
Frequency
Every 4 hours
Estimated price
$15
Schedules at
lineadorada.info
Greyhound Mexico
Phone
01-800 890 6821
Website
greyhound.com.mx
Bus from San Antonio to Matamoros
Ave. Duration
10 h 10 min
Frequency
3 times a day
Estimated price
$50 - $75
Schedules at
greyhound.com.mx

Want to know more about travelling around Guatemala

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Yes, the driving distance between Panama City to Guatemala City is 2325 miles. It takes approximately 46 h 5 min to drive from Panama City to Guatemala City.

Get driving directions

Delta and United Airlines offer flights from Panama City Airport to Guatemala City Airport.

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There are 222+ hotels available in Guatemala City. Prices start at $19 USD per night.

More details

The best way to get from Panama City to Panama City Airport is to taxi which takes 35 min and costs $60 - $75.

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