There are 6 ways to get from Panama City to Guatemala City by plane, bus, train, car or night bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Panama City  •  6 h 55 min

  1. Fly from Panama City (ECP) to Guatemala City (GUA) ECP - GUA

$282 - $1,373

Cheapest option

Bus  •  2 days 19 h

  1. Take the bus from Panama City, Fl to Houston, Tx
  2. Take the bus from Houston, Tx to San Antonio, Tx
  3. Take the bus from San Antonio, Tx to Brownsville, Tx 897
  4. Take the bus from Matamoros to Tapachula
  5. Take the bus from Tapachula, Mexico to Guatemala City Terminal Transgalgos Internacional

$215 - $526

4 alternative options

Bus to Tallahassee, fly  •  12 h 12 min

  1. Take the bus from Panama City, Fl to Tallahassee, Fl
  2. Fly from Tallahassee (TLH) to Guatemala City (GUA) TLH - GUA

$252 - $1,482

Bus, train, drive  •  2 days 19 h

  1. Take the bus from Panama City, Fl to Lafayette, La
  2. Take the train from Lafayette Amtrak to San Antonio Amtrak
  3. Take the bus from San Antonio, Tx to Raymondville, Tx 897
  4. Drive from Raymondville, Tx to Matamoros
  5. Take the bus from Matamoros to Tapachula
  6. Take the bus from Malacatán to Guatemala City

$227 - $527

Bus, night bus  •  2 days 22 h

  1. Take the bus from Panama City, Fl to Houston, Tx
  2. Take the night bus from Houston, Tx to San Antonio, Tx
  3. Take the bus from San Antonio to Matamoros
  4. Take the bus from Matamoros to Tapachula
  5. Take the bus from Tapachula, Mexico to Guatemala City Terminal Transgalgos Internacional

$222 - $471

Drive  •  46 h 5 min

  1. Drive from Panama City to Guatemala City 2325.2 miles

$260 - $390

Questions & Answers

The cheapest way to get from Panama City to Guatemala City is to drive which costs $260 - $390 and takes 46 h 5 min.

More details

The quickest way to get from Panama City to Guatemala City is to fly which takes 6 h 55 min and costs $280 - $1,400.

More details

The distance between Panama City and Guatemala City is 1796 km. The road distance is 3720 km.

Get driving directions

It takes approximately 6 h 55 min to get from Panama City to Guatemala City, including transfers.

More details

No, there is no direct bus from Panama City to Guatemala City. However, there are services departing from Panama City, Fl and arriving at Guatemala City Terminal Transgalgos Internacional via Houston, Tx, San Antonio, Tx, Brownsville, TX, Matamoros and Tapachula, Mexico. The journey, including transfers, takes approximately 2 days 19 h.

More details

What companies run services between Panama City, FL, USA and Guatemala City, Guatemala?

Delta, United Airlines and American Airlines fly from Panama City to Guatemala City every 3 hours. Alternatively, you can take a bus from Panama City to Guatemala City via Houston, Tx, San Antonio, Tx, Brownsville, Tx, Brownsville, TX, Matamoros, Tapachula, and Tapachula, Mexico in around 2 days 19 h.

Airlines
Delta
Website
delta.com
Flights from Panama City to Guatemala City via Atlanta
Ave. Duration
5 h 49 min
When
Every day
Estimated price
$230 - $1,500
Flights from Tallahassee to Guatemala City via Atlanta
Ave. Duration
6 h 40 min
When
Every day
Estimated price
$260 - $1,700
American Airlines
Website
aa.com
Flights from Panama City to Guatemala City via Dallas/Ft.Worth
Ave. Duration
6 h 46 min
When
Every day
Estimated price
$230 - $1,400
Flights from Tallahassee to Guatemala City via Miami
Ave. Duration
7 h 49 min
When
Every day
Estimated price
$200 - $1,400
Flights from Tallahassee to Guatemala City via Dallas/Ft.Worth
Ave. Duration
12 h 55 min
When
Every day
Estimated price
$270 - $1,600
United Airlines
Website
united.com
Flights from Panama City to Guatemala City via Houston
Ave. Duration
6 h 58 min
When
Every day
Estimated price
$220 - $1,300
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Lafayette Amtrak to San Antonio Amtrak
Ave. Duration
11 h 41 min
Frequency
6 times a week
Estimated price
$65 - $180
Website
amtrak.com
Coach Seat
$65 - $100
Flexi Coach Seat
$120 - $170
Business Coach Seat
$130 - $180
Room
$290 - $410
Bus operators
Greyhound USA
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Panama City, Fl to Tallahassee, Fl
Ave. Duration
3 h 15 min
Frequency
Every 30 minutes
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $24
Flexible
$28 - $40
Bus from Panama City, Fl to Houston, Tx
Ave. Duration
16 h 20 min
Frequency
Every 15 minutes
Estimated price
$60 - $160
Website
greyhound.com
Economy
$60 - $110
Flexible
$120 - $160
Bus from Houston, Tx to San Antonio, Tx
Ave. Duration
3 h 15 min
Frequency
Hourly
Estimated price
$24 - $60
Website
greyhound.com
Economy
$24 - $40
Flexible
$45 - $60
Bus from San Antonio, Tx to Brownsville, Tx
Ave. Duration
5 h 50 min
Frequency
Hourly
Estimated price
$30 - $80
Website
greyhound.com
Economy
$30 - $55
Flexible
$60 - $80
Bus from Panama City, Fl to Lafayette, La
Ave. Duration
10 h 40 min
Frequency
Every 30 minutes
Estimated price
$40 - $110
Website
greyhound.com
Economy
$40 - $70
Flexible
$80 - $110
Bus from San Antonio, Tx to Raymondville, Tx
Ave. Duration
4 h 45 min
Frequency
Hourly
Estimated price
$28 - $70
Website
greyhound.com
Economy
$28 - $45
Flexible
$50 - $70
ADO
Phone
+52 800 369 4652
Website
ado.com.mx
Bus from Matamoros to Tapachula
Ave. Duration
30 h 45 min
Frequency
Once daily
Estimated price
$65 - $140
Schedules at
ado.com.mx
First
$70 - $100
Economy
$65 - $100
Trans Galgos Inter
Autobuses FDN
Phone
+502 79477070, +502 22513817, Whatsapp: +502 47397438
Email
info@transportesfuentedelnorte.com
Website
facebook.com
Bus from Malacatán to Guatemala City
Ave. Duration
4 h 30 min
Frequency
Every 4 hours
Estimated price
$16
Schedules at
lineadorada.info
Greyhound Mexico
Phone
01-800 890 6821
Website
greyhound.com.mx
Bus from San Antonio to Matamoros
Ave. Duration
10 h 10 min
Frequency
3 times a day
Estimated price
$45 - $70
Schedules at
greyhound.com.mx

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