There are 4 ways to get from Palestrina to Isernia by train (Trenitalia), bus, car, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train (Trenitalia)
best- Take the train from Zagarolo to Cassinotrain Re
- Take the train from Cassino to Iserniatrain Re
3h 55m€19–27Bus
cheapest- Take the bus from PALESTRINA | Ist. Luzzatti-Livatino # f12259 to ROMA | Ponte Mammolobus Gz33a / ...
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
4h 23m€12–34Drive 142.4 km
- Drive from Palestrina to Iserniacar 142.4 km
1h 40m€23–34Bus, train
- Take the bus from SAN CESAREO | Via Casilina piazza G.Cesare # f6044 to COLLEFERRO | Stazione FS # f4937bus
- Take the train from Colleferro-Segni-Pal to Cassinotrain Re
- Take the train from Cassino to Iserniatrain Re
4h 56m€18–27
Palestrina to Isernia by bus and train (Trenitalia)
Comparing Your Travel Options
The cheapest way to get from Palestrina to Isernia is to train which costs €18 - €28 and takes 3h 55m.
The fastest way to get from Palestrina to Isernia is to drive which takes 1h 40m and costs €22 - €35.
No, there is no direct bus from Palestrina to Isernia. However, there are services departing from PALESTRINA | Ist. Luzzatti-Livatino # f12259 and arriving at Isernia via Ponte Mammolo and Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 4h 23m.
No, there is no direct train from Palestrina to Isernia. However, there are services departing from Zagarolo and arriving at Isernia via Cassino. The journey, including transfers, takes approximately 3h 55m.
The distance between Palestrina and Isernia is 161 km. The road distance is 142.4 km.
The best way to get from Palestrina to Isernia without a car is to train which takes 3h 55m and costs €18 - €28.
It takes approximately 3h 55m to get from Palestrina to Isernia, including transfers.
Palestrina to Isernia bus services, operated by Cotral S.p.A., depart from PALESTRINA | Ist. Luzzatti-Livatino # f12259 station.
Palestrina to Isernia train services, operated by Trenitalia, depart from Zagarolo station.
The best way to get from Palestrina to Isernia is to train which takes 3h 55m and costs €18 - €28. Alternatively, you can bus, which costs €11 - €35 and takes 4h 23m.
What companies run services between Palestrina, Italy and Isernia, Italy?
You can take a bus from PALESTRINA | Via Prenes. Nuova Via Latina # f000031 to Isernia via ZAGAROLO | Stazione FS # f14568, Zagarolo, and Cassino in around 3h 55m. Alternatively, you can take a bus from PALESTRINA | Ist. Luzzatti-Livatino # f12259 to Isernia via Ponte Mammolo and Roma, Autostazione Tiburtina in around 4h 23m.
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Zagarolo to Cassino
- Ave. Duration
- 1h 33m
- Frequency
- Hourly
- Estimated price
- €12–17
- Website
- Trenitalia
Train from Cassino to Isernia
- Ave. Duration
- 42 min
- Frequency
- Every 4 hours
- Estimated price
- €6–9
- Website
- Trenitalia
Train from Colleferro-Segni-Pal to Cassino
- Ave. Duration
- 1h 18m
- Frequency
- Every 30 minutes
- Estimated price
- €10–14
- Website
- Trenitalia
Train from Cassino to Isernia
- Ave. Duration
- 42 min
- Frequency
- Every 4 hours
- Estimated price
- €6–9
- Website
- Trenitalia
- Phone
- 800 174 471
- Website
- Cotral S.p.A.
Bus from PALESTRINA | Ist. Luzzatti-Livatino # f12259 to ROMA | Ponte Mammolo
- Ave. Duration
- 56 min
- Frequency
- Every 3 hours
- Estimated price
- €2–4
- Schedules at
- Cotral S.p.A.
Bus from SAN CESAREO | Via Casilina piazza G.Cesare # f6044 to COLLEFERRO | Stazione FS # f4937
- Ave. Duration
- 45 min
- Frequency
- Hourly
- Estimated price
- €1–3
- Schedules at
- Cotral S.p.A.
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Booking & Getting There
Palestrina to Isernia bus services, operated by Cotral S.p.A., arrive at ROMA | Ponte Mammolo station.
Palestrina to Isernia train services, operated by Trenitalia, arrive at Cassino station.
Yes, the driving distance between Palestrina to Isernia is 142 km. It takes approximately 1h 40m to drive from Palestrina to Isernia.
There are 454+ hotels available in Isernia.