There are 3 ways to get from Palestrina to Isernia by bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus, train
best- Take the bus from PALESTRINA | Via Prenes. Nuova Via Latina # f000031 to COLLEFERRO | Stazione FS # f4930bus
- Take the train from Colleferro-Segni-Pal to Frosinonetrain Re
- Take the train from Frosinone to Iserniatrain Re
4h 11m€12–16Bus
- Take the bus from PALESTRINA | Via Togliatti # f15104 to ROMA | Ponte Mammolobus Gz33a / ...
- Take the bus from Roma, Autostazione Tiburtina to Iserniabus Rome Tiburtina
4h 30m€12–26Drive 142.4 km
- Drive from Palestrina to Iserniacar 142.4 km
1h 40m€22–32
Palestrina to Isernia by bus and train
Questions & Answers
The cheapest way to get from Palestrina to Isernia is to bus and train which costs €11 - €17 and takes 4h 11m.
The fastest way to get from Palestrina to Isernia is to drive which takes 1h 40m and costs €21 - €35.
No, there is no direct bus from Palestrina to Isernia. However, there are services departing from PALESTRINA | Via Togliatti # f15104 and arriving at Isernia via Ponte Mammolo and Roma, Autostazione Tiburtina. The journey, including transfers, takes approximately 4h 30m.
The distance between Palestrina and Isernia is 163 km. The road distance is 142.4 km.
The best way to get from Palestrina to Isernia without a car is to bus and train which takes 4h 11m and costs €11 - €17.
It takes approximately 4h 11m to get from Palestrina to Isernia, including transfers.
Palestrina to Isernia bus services, operated by Cotral S.p.A., depart from PALESTRINA | Via Togliatti # f15104 station.
Palestrina to Isernia bus services, operated by Cotral S.p.A., arrive at ROMA | Ponte Mammolo station.
Yes, the driving distance between Palestrina to Isernia is 142 km. It takes approximately 1h 40m to drive from Palestrina to Isernia.
There are 424+ hotels available in Isernia.
What companies run services between Palestrina, Italy and Isernia, Italy?
You can take a bus from PALESTRINA | Via Togliatti # f15104 to Isernia via Ponte Mammolo and Roma, Autostazione Tiburtina in around 4h 30m.
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Colleferro-Segni-Pal to Frosinone
- Ave. Duration
- 40 min
- Frequency
- Hourly
- Estimated price
- €3
- Website
- https://www.trenitalia.com/en.html
Train from Frosinone to Isernia
- Ave. Duration
- 1h 18m
- Frequency
- Once daily
- Estimated price
- €7–11
- Website
- https://www.trenitalia.com/en.html
- Phone
- 800 174 471
- Website
- servizi.cotralspa.it
Bus from PALESTRINA | Via Prenes. Nuova Via Latina # f000031 to COLLEFERRO | Stazione FS # f4930
- Ave. Duration
- 48 min
- Frequency
- 5 times a week
- Estimated price
- €1–3
- Schedules at
- servizi.cotralspa.it
Bus from PALESTRINA | Via Togliatti # f15104 to ROMA | Ponte Mammolo
- Ave. Duration
- 1h 3m
- Frequency
- Every 3 hours
- Estimated price
- €2–4
- Schedules at
- servizi.cotralspa.it
- Phone
- +39 0874 64744
- info@atm-molise.it
- Website
- atm-molise.it
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- €8–13
- Schedules at
- atm-molise.it
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Roma, Autostazione Tiburtina to Isernia
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- €8–16
- Website
- https://www.flixbus.co.uk
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
















