There are 9 ways to get from Palermo to Siena by plane, train, train (Trenitalia), bus, car ferry, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Florence Peretola Airport, train
best- Fly from Palermo Airport (PMO) to Florence Peretola Airport (FLR)plane PMO - FLR
- Take the train from Firenze S.M.N. to Sienatrain
5h 52m€62–198Bus
cheapest- Take the bus from Palermo to Sienabus FlixBus N597
16h 20m€35–85Train
- Take the train from Palermo Centrale to Roma Terminitrain Ic
- Take the train from Roma Termini to Florence Santa Maria Novellatrain
- Take the train from Firenze S.M.N. to Sienatrain Re
16h 1m€61–168Car ferry, drive
- Take the car ferry from Port of Palermo to Livornocarferry
- Drive from Livorno to Sienacar
21h 15m€68–97Fly to Pisa International Airport, train
- Fly from Palermo Airport (PMO) to Pisa International Airport (PSA)plane PMO - PSA
- Take the train from Pisa Centrale to Empolitrain
- Take the train from Empoli to Sienatrain
5h 39m€74–225Fly to Bologna Guglielmo Marconi Airport, train
- Fly from Palermo Airport (PMO) to Bologna Guglielmo Marconi Airport (BLQ)plane PMO - BLQ
- Take the train from Bologna Centrale to Florence Santa Maria Novellatrain
- Take the train from Firenze S.M.N. to Sienatrain
6h 48m€80–270Fly to Perugia Sant'Egidio Airport, bus
- Fly from Palermo Airport (PMO) to Perugia Sant'Egidio Airport (PEG)plane PMO - PEG
- Take the bus from Perugia to Sienabus
7h 8m€47–299Bus via Rome
- Take the bus from Palermo Terminal Bus to Roma, Autostazione Tiburtinabus Itabus
- Take the bus from Roma, Autostazione Tiburtina to Siena - p.zza Rossellibus Lamezia Terme
17h 25m€41–57Train via Chiusi (Trenitalia)
- Take the train from Palermo Centrale to Roma Terminitrain Ic
- Take the train from Roma Termini to Chiusi-Chianciano T.train
- Take the train from Chiusi-Chianciano T. to Sienatrain Re
18h 5m€47–142
Palermo to Siena by train
Questions & Answers
The cheapest way to get from Palermo to Siena is to bus via Rome which costs €40 - €60 and takes 17h 25m.
The fastest way to get from Palermo to Siena is to fly and train which takes 5h 39m and costs €70 - €230.
Yes, there is a direct bus departing from Palermo and arriving at Siena. Services depart twice daily, and operate every day. The journey takes approximately 16h 20m.
No, there is no direct train from Palermo to Siena. However, there are services departing from Palermo Centrale and arriving at Siena via Roma Termini and Firenze S.M.N.. The journey, including transfers, takes approximately 16h 1m.
The distance between Palermo and Siena is 773 km.
The best way to get from Palermo to Siena without a car is to train which takes 16h 1m and costs €60 - €170.
It takes approximately 5h 52m to get from Palermo to Siena, including transfers.
Palermo to Siena bus services, operated by FlixBus-eu, depart from Palermo station.
Palermo to Siena train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
The best way to get from Palermo to Siena is to train which takes 16h 1m and costs €60 - €170. Alternatively, you can bus, which costs €35 - €85 and takes 16h 20m.
What companies run services between Palermo, Italy and Siena, Italy?
You can take a train from Palermo Centrale to Siena via Roma Termini and Firenze S.M.N. in around 16h 1m. Alternatively, FlixBus-eu operates a bus from Palermo to Siena once daily, and the journey takes 16h 20m. FlixBus also services this route once daily.
- Website
- ryanair.com
Flights from Palermo Airport to Pisa International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €45–200
Flights from Palermo Airport to Pisa International Airport via Bari
- Ave. Duration
- 3h 35m
- When
- Saturday
- Estimated price
- €45–200
Flights from Palermo Airport to Bologna Guglielmo Marconi Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €35–200
Flights from Palermo Airport to Perugia Sant'Egidio Airport
- Ave. Duration
- 1h 15m
- When
- Monday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €35–240
- Website
- ita-airways.com
Flights from Palermo Airport to Florence Peretola Airport via Rome
- Ave. Duration
- 3h 20m
- When
- Every day
- Estimated price
- €70–160
Flights from Palermo Airport to Bologna Guglielmo Marconi Airport via Rome
- Ave. Duration
- 3h 22m
- When
- Every day
- Estimated price
- €45–160
- Website
- volotea.com
Flights from Palermo Airport to Florence Peretola Airport
- Ave. Duration
- 1h 25m
- When
- Monday, Thursday, and Friday
- Estimated price
- €29–140
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Firenze S.M.N. to Siena
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €11
- Website
- https://www.trenitalia.com/en.html
Train from Pisa Centrale to Empoli
- Ave. Duration
- 45 min
- Frequency
- Every 30 minutes
- Estimated price
- €7
- Website
- https://www.trenitalia.com/en.html
Train from Empoli to Siena
- Ave. Duration
- 1h
- Frequency
- Hourly
- Estimated price
- €8
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Chiusi-Chianciano T.
- Ave. Duration
- 1h 44m
- Frequency
- Every 4 hours
- Estimated price
- €12–13
- Website
- https://www.trenitalia.com/en.html
Train from Chiusi-Chianciano T. to Siena
- Ave. Duration
- 1h 27m
- Frequency
- Every 2 hours
- Estimated price
- €10
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Palermo Centrale to Roma Termini
- Ave. Duration
- 11h 34m
- Frequency
- Once daily
- Estimated price
- €27–110
- Website
- https://www.trenitalia.com/en.html
Train from Roma Termini to Chiusi-Chianciano T.
- Ave. Duration
- 1h 48m
- Frequency
- 3 times a day
- Estimated price
- €9–21
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Roma Termini to Florence Santa Maria Novella
- Ave. Duration
- 1h 32m
- Frequency
- Hourly
- Estimated price
- €22–55
- Website
- https://www.italotreno.it/en
Train from Bologna Centrale to Florence Santa Maria Novella
- Ave. Duration
- 36 min
- Frequency
- Hourly
- Estimated price
- €13–35
- Website
- https://www.italotreno.it/en
- Website
- global.flixbus.com
Bus from Palermo to Siena
- Ave. Duration
- 16h 20m
- Frequency
- Once daily
- Schedules at
- global.flixbus.com
Bus from Perugia to Siena
- Ave. Duration
- 1h 25m
- Frequency
- Twice daily
- Schedules at
- global.flixbus.com
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Palermo to Siena
- Ave. Duration
- 16h 30m
- Frequency
- Once daily
- Estimated price
- €35–85
- Website
- https://www.flixbus.co.uk
Bus from Perugia to Siena
- Ave. Duration
- 1h 25m
- Frequency
- Twice daily
- Estimated price
- €6–10
- Website
- https://www.flixbus.co.uk
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Palermo Terminal Bus to Roma, Autostazione Tiburtina
- Ave. Duration
- 13h 25m
- Frequency
- 3 times a week
- Estimated price
- €30–45
- Website
- https://www.itabus.it/en/home
Bus from Roma, Autostazione Tiburtina to Siena - p.zza Rosselli
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- €10–15
- Schedules at
- autolineefederico.it
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Car ferry from Port of Palermo to Livorno
- Ave. Duration
- 19h 30m
- Frequency
- 3 times a week
- Estimated price
- €50–70
- Website
- https://www.grimaldi-lines.com/en/
Want to know more about travelling around Italy
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More Questions & Answers
Palermo to Siena bus services, operated by FlixBus-eu, arrive at Siena station.
Palermo to Siena train services, operated by Trenitalia Intercity, arrive at Roma Termini station.
Book your Palermo to Siena train tickets online with Omio.
Book your Palermo to Siena bus tickets online with Omio and FlixBus.
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