There are 10 ways to get from Palermo to Santander by plane, car ferry, car, train, bus, or ferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Santander Airport
best- Fly from Palermo Airport (PMO) to Santander Airport (SDR)plane PMO - SDR
7h 44m€94–165Fly to Bilbao Airport, bus
cheapest- Fly from Palermo Airport (PMO) to Bilbao Airport (BIO)plane PMO - BIO
- Take the bus from Bilbao Intermodal to Santander E.A.bus
8h€73–213Car ferry, drive
- Take the car ferry from Port of Palermo to Port of Genoacarferry
- Drive from Port of Genoa to Santandercar
33h 6m€257–405Train, bus
- Take the train from Palermo Centrale to Roma Terminitrain Ic
- Take the train from Roma Termini to Milano Centraletrain Fr / ...
- Take the train from Milano Centrale to Lyon Part Dieutrain Fr
- Take the train from Lyon Part Dieu to Massy Tgvtrain Tgv
- Take the train from Massy Tgv to Bordeaux St Jeantrain Tgv
- Take the bus from Bordeaux to Santanderbus
34h 36m€222–742Bus
- Take the bus from Palermo to Florence Villa Constanza Bus Stationbus
- Take the bus from Florence Villa Constanza Bus Station to Bordeauxbus
- Take the bus from Bordeaux to Santanderbus
42h 45m€110–241Fly to Asturias Airport, bus
- Fly from Palermo Airport (PMO) to Asturias Airport (OVD)plane PMO - OVD
- Take the bus from [ANZU|Aeropuerto] Aeropuerto - Salidas [CTA 20118] to [OVIEDO/UVIÉU] Estación Bus Oviedo FL- Pepe Cosmen [CTA 01549]bus
- Take the bus from Oviedo to Santander E.A.bus
13h 11m€97–321Fly to Adolfo Suárez Madrid–Barajas Airport, train
- Fly from Palermo Airport (PMO) to Adolfo Suárez Madrid–Barajas Airport (MAD)plane PMO - MAD
- Take the train from Madrid Chamartín to Santandertrain
11h 5m€92–283Car ferry, bus, train
- Take the car ferry from Port of Palermo to Port of Genoacarferry
- Take the bus from Genoa to Marseillebus
- Take the train from Marseille St Charles to Madrid-Puerta de Atocha-Almudena Grandestrain
- Take the train from Madrid Chamartín to Santandertrain Alv / ...
42h 58m€209–367Bus via Barcelona
- Take the bus from Palermo Terminal Bus to Napoli, Autostazione Metroparkbus
- Take the bus from Naples - Bus Station to Barcelona - North Bus Stationbus
- Take the bus from Barcelona, Estació d'Autobusos Nord to Santander E.A.bus
45h 50m€165–264Ferry, train
- Take the ferry from Port of Palermo to Port of Civitavecchiaferry
- Take the ferry from Port of Civitavecchia to Port de Barcelonaferry
- Take the train from Barcelona-Sants to Bilbao-Abandotrain Alv
- Take the train from Bilbao to Santandertrain
45h 53m€141–241
Palermo to Santander by train, foot, and bus
Questions & Answers
The cheapest way to get from Palermo to Santander is to fly which costs €90 - €170 and takes 7h 44m.
The fastest way to get from Palermo to Santander is to fly which takes 7h 44m and costs €90 - €170.
No, there is no direct bus from Palermo to Santander. However, there are services departing from Palermo and arriving at Santander via Florence Villa Constanza Bus Station and Bordeaux. The journey, including transfers, takes approximately 42h 45m.
The distance between Palermo and Santander is 1567 km.
The best way to get from Palermo to Santander without a car is to train and bus which takes 34h 36m and costs €220 - €750.
It takes approximately 7h 44m to get from Palermo to Santander, including transfers.
Palermo to Santander bus services, operated by FlixBus, depart from Palermo station.
The best way to get from Palermo to Santander is to fly which takes 7h 44m and costs €90 - €170. Alternatively, you can bus, which costs €110 - €250 and takes 42h 45m.
Palermo to Santander bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Book your Palermo to Santander bus tickets online with Omio and FlixBus.
What companies run services between Palermo, Italy and Santander, Spain?
Ryanair, Iberia, and Vueling Airlines fly from Palermo Airport (PMO) to Santander Airport (SDR) once daily. Alternatively, you can take a bus from Palermo to Santander via Florence Villa Constanza Bus Station and Bordeaux in around 42h 45m.
- Website
- iberia.com
Flights from Palermo Airport to Santander Airport via Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 6h 32m
- When
- Tuesday to Sunday
- Estimated price
- €70–280
Flights from Palermo Airport to Santander Airport via Barcelona
- Ave. Duration
- 6h 40m
- When
- Tuesday, Friday, and Sunday
- Estimated price
- €70–270
Flights from Palermo Airport to Asturias Airport via Barcelona
- Ave. Duration
- 7h 20m
- When
- Wednesday and Sunday
- Estimated price
- €55–230
Flights from Palermo Airport to Asturias Airport via Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 7h 35m
- When
- Tuesday to Friday
- Estimated price
- €60–240
Flights from Palermo Airport to Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 2h 40m
- When
- Monday and Thursday
- Estimated price
- €65–280
Flights from Palermo Airport to Adolfo Suárez Madrid–Barajas Airport via Barcelona
- Ave. Duration
- 4h 52m
- When
- Wednesday and Sunday
- Estimated price
- €120–180
- Website
- vueling.com
Flights from Palermo Airport to Santander Airport via Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 6h 32m
- When
- Tuesday to Sunday
- Estimated price
- €70–280
Flights from Palermo Airport to Santander Airport via Barcelona
- Ave. Duration
- 6h 40m
- When
- Tuesday, Friday, and Sunday
- Estimated price
- €70–270
Flights from Palermo Airport to Asturias Airport via Barcelona
- Ave. Duration
- 7h 20m
- When
- Wednesday and Sunday
- Estimated price
- €55–230
Flights from Palermo Airport to Asturias Airport via Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 7h 35m
- When
- Tuesday to Friday
- Estimated price
- €60–240
Flights from Palermo Airport to Adolfo Suárez Madrid–Barajas Airport via Barcelona
- Ave. Duration
- 4h 52m
- When
- Wednesday and Sunday
- Estimated price
- €120–180
- Website
- volotea.com
Flights from Palermo Airport to Asturias Airport via Milan Bergamo
- Ave. Duration
- 5h 50m
- When
- Tuesday, Thursday, and Saturday
- Estimated price
- €85–310
Flights from Palermo Airport to Asturias Airport via Rome
- Ave. Duration
- 7h 2m
- When
- Tuesday
- Estimated price
- €75–300
Flights from Palermo Airport to Asturias Airport via Barcelona
- Ave. Duration
- 7h 40m
- When
- Friday and Sunday
- Estimated price
- €60–240
Flights from Palermo Airport to Bilbao Airport
- Ave. Duration
- 2h 30m
- When
- Saturday
- Estimated price
- €60–260
- Website
- ryanair.com
Flights from Palermo Airport to Asturias Airport via Rome
- Ave. Duration
- 12h 32m
- When
- Wednesday and Sunday
- Estimated price
- €65–240
Flights from Palermo Airport to Adolfo Suárez Madrid–Barajas Airport
- Ave. Duration
- 2h 30m
- When
- Tuesday to Sunday
- Estimated price
- €45–170
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Palermo Centrale to Roma Termini
- Ave. Duration
- 11h 34m
- Frequency
- Once daily
- Estimated price
- €27–110
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 8m
- Frequency
- Every 30 minutes
- Estimated price
- €35–110
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 40m
- Frequency
- Every 2 hours
- Estimated price
- €45–100
- Website
- https://www.italotreno.it/en
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Milano Centrale to Lyon Part Dieu
- Ave. Duration
- 4h 39m
- Frequency
- Twice daily
- Estimated price
- €50–110
- Website
- https://www.trenitalia.com/en.html
- Phone
- +33 1 84 94 36 35
- Website
- sncf-connect.com
Train from Lyon Part Dieu to Massy Tgv
- Ave. Duration
- 2h 1m
- Frequency
- Every 4 hours
- Estimated price
- €45–120
- Website
- https://www.sncf-connect.com/en-en
Train from Massy Tgv to Bordeaux St Jean
- Ave. Duration
- 2h 57m
- Frequency
- Every 4 hours
- Estimated price
- €45–130
- Website
- https://www.sncf-connect.com/en-en
Rome2Rio's guide to Société Nationale des Chemins de fer Français (SNCF)
Contact Details
- Phone
- +33 1 84 94 36 35
- Website
- track.effiliation.com
Train from Lyon Part Dieu to Massy Tgv
- Ave. Duration
- 2h 1m
- Frequency
- Every 4 hours
- Estimated price
- €70–160
- Website
- https://track.effiliation.com/servlet/effi.redir?id_compteur=23007591&url=https%3A%2F%2Fwww.sncf-connect.com%2Fen-en%2F
- 2nd Class
- €70–110
- Rail 1st Class
- €110–160
Train from Massy Tgv to Bordeaux St Jean
- Ave. Duration
- 2h 57m
- Frequency
- Once daily
- Estimated price
- €90–200
- Website
- https://track.effiliation.com/servlet/effi.redir?id_compteur=23007591&url=https%3A%2F%2Fwww.sncf-connect.com%2Fen-en%2F
- 2nd Class
- €90–130
- Rail 1st Class
- €130–200
- Phone
- +33 2 22 55 00 10
- nomad-car@laregionnormandie.fr
- Website
- nomad.normandie.fr
Train from Lyon Part Dieu to Massy Tgv
- Ave. Duration
- 2h 7m
- Frequency
- 5 times a week
- Schedules at
- nomad.normandie.fr
- Phone
- +34 91 232 03 20
- Website
- renfe.com
Train from Madrid Chamartín to Santander
- Ave. Duration
- 4h 20m
- Frequency
- Twice daily
- Estimated price
- €30–85
- Website
- https://www.renfe.com/es/en
Train from Marseille St Charles to Madrid-Puerta de Atocha-Almudena Grandes
- Ave. Duration
- 7h 48m
- Frequency
- Once daily
- Estimated price
- €90–130
- Website
- https://www.renfe.com/es/en
Train from Barcelona-Sants to Bilbao-Abando
- Ave. Duration
- 7h 3m
- Frequency
- Once daily
- Estimated price
- €25–75
- Website
- https://www.renfe.com/es/en
Train from Bilbao to Santander
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- €9
- Website
- https://www.renfe.com/es/en
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Bordeaux to Santander
- Ave. Duration
- 6h 5m
- Frequency
- Once daily
- Estimated price
- €19–60
- Website
- https://www.flixbus.co.uk
Bus from Palermo to Florence Villa Constanza Bus Station
- Ave. Duration
- 17h 30m
- Frequency
- Twice daily
- Estimated price
- €35–85
- Website
- https://www.flixbus.co.uk
Bus from Florence Villa Constanza Bus Station to Bordeaux
- Ave. Duration
- 17h 10m
- Frequency
- Once daily
- Estimated price
- €55–100
- Website
- https://www.flixbus.co.uk
Bus from Genoa to Marseille
- Ave. Duration
- 6h 35m
- Frequency
- Every 4 hours
- Estimated price
- €20–35
- Website
- https://www.flixbus.co.uk
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Palermo to Florence Villa Constanza Bus Station
- Ave. Duration
- 15h
- Frequency
- Once a week
- Estimated price
- €50–75
- Schedules at
- autoservizisalemi.it
- Phone
- +34 910 207 007
- alsa@alsa.es
- Website
- alsa.com
Bus from [ANZU|Aeropuerto] Aeropuerto - Salidas [CTA 20118] to [OVIEDO/UVIÉU] Estación Bus Oviedo FL- Pepe Cosmen [CTA 01549]
- Ave. Duration
- 40 min
- Frequency
- Every 30 minutes
- Estimated price
- €3–6
- Website
- https://www.alsa.com/en/
Bus from Oviedo to Santander E.A.
- Ave. Duration
- 2h 45m
- Frequency
- Every 4 hours
- Estimated price
- €15–30
- Website
- https://www.alsa.com/en/
Bus from Bilbao Intermodal to Santander E.A.
- Ave. Duration
- 1h 30m
- Frequency
- Hourly
- Estimated price
- €8–15
- Website
- https://www.alsa.com/en/
Bus from Barcelona, Estació d'Autobusos Nord to Santander E.A.
- Ave. Duration
- 9h 30m
- Frequency
- 3 times a day
- Estimated price
- €65–120
- Website
- https://www.alsa.com/en/
- Phone
- +39 06 88 93 82 32
- Website
- itabus.it
Bus from Palermo Terminal Bus to Napoli, Autostazione Metropark
- Ave. Duration
- 10h 40m
- Frequency
- 3 times a week
- Estimated price
- €24–35
- Website
- https://www.itabus.it/en/home
- Phone
- +3-389-268-0068
- Website
- blablacar.co.uk
Bus from Naples - Bus Station to Barcelona - North Bus Station
- Ave. Duration
- 23h 40m
- Frequency
- Twice daily
- Estimated price
- €75–110
- Website
- https://www.blablacar.co.uk/bus
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Palermo to Port of Genoa
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €65–120
- Website
- https://www.gnv.it/en
Ferry from Port of Palermo to Port of Civitavecchia
- Ave. Duration
- 12h
- Frequency
- Once a week
- Estimated price
- €55–65
- Website
- https://www.gnv.it/en
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Ferry from Port of Civitavecchia to Port de Barcelona
- Ave. Duration
- 20h
- Frequency
- 5 times a week
- Estimated price
- €45–90
- Website
- https://www.grimaldi-lines.com/en/
Want to know more about travelling around Spain
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
5 delightfully under-the-radar French towns you need to visit
Read the travel guide
Train travel in France: A guide to SNCF
Read the travel guide
More Questions & Answers
There are 2052+ hotels available in Santander.






























































