There are 9 ways to get from Palermo to Mainz by plane, train (Trenitalia), car ferry, car, bus, train, or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Palermo Airport to Frankfurt
best- Fly from Palermo Airport (PMO) to Frankfurt (FRA)plane PMO - FRA
5h 51m€96–290Fly Palermo Airport to Hahn, bus
cheapest- Fly from Palermo Airport (PMO) to Hahn (HHN)plane PMO - HHN
- Take the bus from Frankfurt Hahn Airport to Mainz Short-term parking lot Am Schlagbus
7h 19m€71–242Train
- Take the train from Palermo Centrale to Roma Terminitrain Ic
- Take the train from Roma Termini to Milano Centraletrain
- Take the train from Milano Centrale to Mannheim Hbftrain Ec
- Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain S5 / ...
24h 19m€298–565Car ferry, drive
- Take the car ferry from Port of Palermo to Port of Genoacarferry
- Drive from Port of Genoa to Mainzcar
28h 17m€217–324Bus, train, night train
- Take the bus from Palermo Via Tommaso Fazello to Milano, San Donato M3bus
- Take the train from Milano Centrale to Zuerich Hbtrain Ec
- Take the night train from Zuerich Hb to Mannheim Hbfnighttrain Nj
- Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain S5 / ...
30h 56m€156–317Train to Catania–Fontanarossa Airport, fly to Frankfurt
- Take the train from Palermo Centrale to Catania Centraletrain
- Fly from Catania–Fontanarossa Airport (CTA) to Frankfurt (FRA)plane CTA - FRA
8h 28m€125–368Fly Palermo Airport to Stuttgart Airport, train
- Fly from Palermo Airport (PMO) to Stuttgart Airport (STR)plane PMO - STR
- Take the train from Hauptbahnhof to Frankfurttrain
7h 56m€134–340Car ferry, train
- Take the car ferry from Port of Palermo to Port of Genoacarferry
- Take the train from Genova P.Za Principe to Milano Centraletrain Ic
- Take the train from Milano Centrale to Mannheim Hbftrain Ec
- Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain S5 / ...
32h 37m€215–361Bus
- Take the bus from Palermo to Milano, Autostazione Lampugnanobus N597
- Take the bus from Milan to Mainz central train stationbus FlixBus 476
35h 45m€112–279
Palermo to Mainz by train
Questions & Answers
The cheapest way to get from Palermo to Mainz is to fly and bus which costs €70 - €250 and takes 7h 19m.
The fastest way to get from Palermo to Mainz is to fly which takes 5h 51m and costs €95 - €290.
No, there is no direct bus from Palermo to Mainz station. However, there are services departing from Palermo and arriving at Mainz central train station via Milan. The journey, including transfers, takes approximately 35h 45m.
No, there is no direct train from Palermo to Mainz. However, there are services departing from Palermo Centrale and arriving at Mainz, Römisches Theater via Roma Termini, Milano Centrale and Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 24h 19m.
The distance between Palermo and Mainz is 1425 km.
The best way to get from Palermo to Mainz without a car is to train which takes 24h 19m and costs €290 - €600.
It takes approximately 5h 51m to get from Palermo to Mainz, including transfers.
Palermo to Mainz bus services, operated by FlixBus, depart from Palermo station.
Palermo to Mainz train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
The best way to get from Palermo to Mainz is to fly which takes 5h 51m and costs €95 - €290. Alternatively, you can train, which costs €290 - €600 and takes 24h 19m, you could also bus, which costs €110 - €280 and takes 35h 45m.
What companies run services between Palermo, Italy and Mainz, Germany?
Lufthansa, ITA Airways, and Air Dolomiti fly from Palermo Airport (PMO) to Frankfurt (FRA) 5 times a day. Alternatively, you can take a train from Palermo Centrale to Mainz, Römisches Theater via Roma Termini, Milano Centrale, Mannheim Hbf, and Mannheim, Hauptbahnhof in around 24h 19m.
- Website
- ita-airways.com
Flights from Palermo Airport to Frankfurt via Munich
- Ave. Duration
- 4h 10m
- When
- Every day
- Estimated price
- €80–340
Flights from Palermo Airport to Frankfurt via Milan Linate
- Ave. Duration
- 5h 11m
- When
- Every day
- Estimated price
- €85–270
Flights from Catania–Fontanarossa Airport to Frankfurt
- Ave. Duration
- 2h 35m
- When
- Every day
- Estimated price
- €95–270
Flights from Catania–Fontanarossa Airport to Frankfurt via Milan Linate
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- €85–360
- Website
- lufthansa.com
Flights from Palermo Airport to Frankfurt
- Ave. Duration
- 2h 30m
- When
- Monday, Tuesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- €80–330
Flights from Palermo Airport to Frankfurt via Munich
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- €80–340
Flights from Catania–Fontanarossa Airport to Frankfurt
- Ave. Duration
- 2h 35m
- When
- Every day
- Estimated price
- €95–270
Flights from Catania–Fontanarossa Airport to Frankfurt via Munich
- Ave. Duration
- 4h 10m
- When
- Every day
- Estimated price
- €60–330
Flights from Palermo Airport to Stuttgart Airport via Munich
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- €95–400
- Website
- eurowings.com
Flights from Palermo Airport to Stuttgart Airport
- Ave. Duration
- 2h 5m
- When
- Wednesday and Saturday
- Estimated price
- €100–220
- Website
- ryanair.com
Flights from Palermo Airport to Hahn
- Ave. Duration
- 2h 20m
- When
- Tuesday, Wednesday, Thursday, and Sunday
- Estimated price
- €50–200
- Website
- swiss.com
Flights from Palermo Airport to Stuttgart Airport via Zurich
- Ave. Duration
- 3h 40m
- When
- Monday, Tuesday, and Saturday
- Estimated price
- €90–350
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Palermo Centrale to Roma Termini
- Ave. Duration
- 11h 34m
- Frequency
- Once daily
- Estimated price
- €85–200
- Website
- https://www.trenitalia.com/en.html
Train from Genova P.Za Principe to Milano Centrale
- Ave. Duration
- 1h 36m
- Frequency
- Hourly
- Estimated price
- €14–35
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 5m
- Frequency
- Every 30 minutes
- Estimated price
- €75–160
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Milano Centrale to Mannheim Hbf
- Ave. Duration
- 6h 48m
- Frequency
- Once daily
- Estimated price
- €120–180
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €120–180
- 2nd Class
- €120–160
Train from Milano Centrale to Zuerich Hb
- Ave. Duration
- 3h 17m
- Frequency
- Every 2 hours
- Estimated price
- €55–110
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €70–110
- 2nd Class
- €55–75
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €18–27
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 57 min
- Frequency
- 5 times a week
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- +43 51717
- Website
- nightjet.com
Night train from Zuerich Hb to Mannheim Hbf
- Ave. Duration
- 4h 21m
- Frequency
- Once a week
- Estimated price
- €27–95
- Website
- https://www.nightjet.com/en/#/home
- Sleeper Carriage
- €93–95
- Couchette Carriage
- €55–70
- Seating Carriage
- €27–33
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Palermo Centrale to Catania Centrale
- Ave. Duration
- 2h 57m
- Frequency
- 5 times a day
- Estimated price
- €30–55
- Website
- https://www.trenitalia.com/en.html
Train from Genova P.Za Principe to Milano Centrale
- Ave. Duration
- 1h 53m
- Frequency
- Every 4 hours
- Estimated price
- €18–30
- Website
- https://www.trenitalia.com/en.html
- Phone
- +49 30 311 682904
- Website
- bahn.de
Train from Hauptbahnhof to Frankfurt
- Ave. Duration
- 1h 12m
- Frequency
- Hourly
- Estimated price
- €30–75
- Website
- https://int.bahn.de/en
- Phone
- +31 30 751 5155
- Website
- ns.nl
Train from Hauptbahnhof to Frankfurt
- Ave. Duration
- 1h 12m
- Frequency
- Once daily
- Estimated price
- €19–50
- Website
- https://www.ns.nl/en
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Genova P.Za Principe to Milano Centrale
- Ave. Duration
- 1h 41m
- Frequency
- Twice daily
- Estimated price
- €20–40
- Schedules at
- trenitalia.com
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Palermo Via Tommaso Fazello to Milano, San Donato M3
- Ave. Duration
- 19h 10m
- Frequency
- Once a week
- Estimated price
- €55–85
- Schedules at
- autoservizisalemi.it
Bus from Palermo to Milano, Autostazione Lampugnano
- Ave. Duration
- 19h 50m
- Frequency
- Once a week
- Estimated price
- €60–90
- Schedules at
- autoservizisalemi.it
- info@flibco.com
- Website
- flibco.com
Bus from Frankfurt Hahn Airport to Mainz Short-term parking lot Am Schlag
- Ave. Duration
- 1h 15m
- Frequency
- Every 2 hours
- Estimated price
- €17–35
- Website
- https://www.flibco.com/en
Rome2Rio's guide to FlixBus
Contact Details
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Palermo to Milano, Autostazione Lampugnano
- Ave. Duration
- 22h 30m
- Frequency
- Once daily
- Estimated price
- €110–190
- Website
- https://www.flixbus.co.uk
Bus from Milan to Mainz central train station
- Ave. Duration
- 12h 15m
- Frequency
- Once daily
- Estimated price
- €50–90
- Website
- https://www.flixbus.co.uk
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Palermo to Port of Genoa
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €95–150
- Website
- https://www.gnv.it/en
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More Questions & Answers
Palermo to Mainz bus services, operated by FlixBus, arrive at Milano, Autostazione Lampugnano station.
Palermo to Mainz train services, operated by Trenitalia Intercity, arrive at Roma Termini station.
Book your Palermo to Mainz train tickets online with Omio.
Book your Palermo to Mainz bus tickets online with Omio and FlixBus.
There are 406+ hotels available in Mainz.































































