There are 7 ways to get from Palermo to Mainz by plane, train, ferry, car ferry, car, bus, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Palermo Airport (PMO) to Frankfurt (FRA)plane PMO - FRA
5h 44m€101–288Bus
cheapest- Take the bus from Palermo to Milano, Autostazione Lampugnanobus N597
- Take the bus from Milano, Autostazione Lampugnano to Mainz central train stationbus 476
35h 30m€96–273Train, ferry
- Take the train from Palermo Centrale to Messina Centraletrain Re
- Take the ferry from Messina Marittima to Villa S.Giovanniferry M1 / ...
- Take the train from Villa S.Giovanni to Milano Centraletrain Fr
- Take the train from Milano Centrale to Mannheim Hbftrain Ec
- Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain S5 / ...
23h 5mCar ferry, drive
- Take the car ferry from Port of Palermo to Port of Genoacarferry
- Drive from Port of Genoa to Mainzcar
28h 16m€183–314Bus, train
- Take the bus from Palermo Via Tommaso Fazello to Milano, San Donato M3bus
- Take the bus from Milan to Mannheim Central Bus Stationbus
- Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain S5 / ...
33h 24m€121–172Train
- Take the train from Palermo Centrale to Roma Terminitrain Ic
- Take the train from Roma Termini to Milano Centraletrain Fr / ...
- Take the train from Milano Centrale to Mannheim Hbftrain Ec
- Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain S5 / ...
24h 16m€196–422Car ferry, train
- Take the car ferry from Port of Palermo to Port of Genoacarferry
- Take the train from Genova P.Za Principe to Milano Centraletrain Ic
- Take the train from Milano Centrale to Mannheim Hbftrain Ec
- Take the train from Mannheim, Hauptbahnhof to Mainz, Römisches Theatertrain S5 / ...
32h 35m€176–339
Palermo Airport (PMO) to Frankfurt (FRA) flights
Questions & Answers
The cheapest way to get from Palermo to Mainz is to bus and train which costs €120 - €180 and takes 33h 24m.
The fastest way to get from Palermo to Mainz is to fly which takes 5h 44m and costs €100 - €290.
No, there is no direct bus from Palermo to Mainz station. However, there are services departing from Palermo and arriving at Mainz central train station via Milano, Autostazione Lampugnano. The journey, including transfers, takes approximately 35h 30m.
No, there is no direct train from Palermo to Mainz. However, there are services departing from Palermo Centrale and arriving at Mainz, Römisches Theater via Roma Termini, Milano Centrale and Mannheim, Hauptbahnhof. The journey, including transfers, takes approximately 24h 16m.
The distance between Palermo and Mainz is 1425 km.
The best way to get from Palermo to Mainz without a car is to train and ferry which takes 23h 5m and costs .
It takes approximately 5h 44m to get from Palermo to Mainz, including transfers.
Palermo to Mainz bus services, operated by FlixBus, depart from Palermo station.
Palermo to Mainz train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
The best way to get from Palermo to Mainz is to fly which takes 5h 44m and costs €100 - €290. Alternatively, you can train, which costs €190 - €430 and takes 24h 16m, you could also bus, which costs €95 - €280 and takes 35h 30m.
What companies run services between Palermo, Italy and Mainz, Germany?
Lufthansa, ITA Airways, and Air Dolomiti fly from Palermo Airport (PMO) to Frankfurt (FRA) 3 times a day. Alternatively, you can take a train from Palermo Centrale to Mainz, Römisches Theater via Roma Termini, Milano Centrale, Mannheim Hbf, and Mannheim, Hauptbahnhof in around 24h 16m.
- Website
- ita-airways.com
Flights from Palermo Airport to Frankfurt via Munich
- Ave. Duration
- 3h 50m
- When
- Saturday and Sunday
- Estimated price
- €120–390
Flights from Palermo Airport to Frankfurt via Milan Linate
- Ave. Duration
- 5h 16m
- When
- Every day
- Estimated price
- €80–240
- Website
- lufthansa.com
Flights from Palermo Airport to Frankfurt
- Ave. Duration
- 2h 25m
- When
- Saturday
- Estimated price
- €120–390
Flights from Palermo Airport to Frankfurt via Munich
- Ave. Duration
- 3h 50m
- When
- Saturday and Sunday
- Estimated price
- €120–390
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Palermo Centrale to Messina Centrale
- Ave. Duration
- 2h 44m
- Frequency
- Every 4 hours
- Estimated price
- €17
- Website
- https://www.trenitalia.com/en.html
Train from Genova P.Za Principe to Milano Centrale
- Ave. Duration
- 1h 53m
- Frequency
- Every 4 hours
- Estimated price
- €10–25
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Palermo Centrale to Messina Centrale
- Ave. Duration
- 2h 55m
- Frequency
- Twice daily
- Estimated price
- €14–26
- Website
- https://www.trenitalia.com/en.html
Train from Villa S.Giovanni to Milano Centrale
- Ave. Duration
- 14h 43m
- Frequency
- Twice a week
- Estimated price
- €60–140
- Website
- https://www.trenitalia.com/en.html
Train from Palermo Centrale to Roma Termini
- Ave. Duration
- 11h 29m
- Frequency
- Once daily
- Estimated price
- €27–110
- Website
- https://www.trenitalia.com/en.html
Train from Genova P.Za Principe to Milano Centrale
- Ave. Duration
- 1h 33m
- Frequency
- Hourly
- Estimated price
- €14–22
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Villa S.Giovanni to Milano Centrale
- Ave. Duration
- 8h 43m
- Frequency
- 4 times a day
- Estimated price
- €95–240
- Schedules at
- trenitalia.com
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 8m
- Frequency
- Every 30 minutes
- Estimated price
- €35–110
- Schedules at
- trenitalia.com
Train from Genova P.Za Principe to Milano Centrale
- Ave. Duration
- 1h 37m
- Frequency
- Twice daily
- Estimated price
- €16–35
- Schedules at
- trenitalia.com
- Phone
- +39 06 8937 1892
- Website
- italotreno.it
Train from Villa S.Giovanni to Milano Centrale
- Ave. Duration
- 9h 33m
- Frequency
- Twice daily
- Estimated price
- €70–180
- Website
- https://www.italotreno.it/en
Train from Roma Termini to Milano Centrale
- Ave. Duration
- 3h 40m
- Frequency
- Hourly
- Estimated price
- €45–120
- Website
- https://www.italotreno.it/en
Train from Genova P.Za Principe to Milano Centrale
- Ave. Duration
- 1h 51m
- Frequency
- Once daily
- Estimated price
- €11–28
- Website
- https://www.italotreno.it/en
- Phone
- +39 06 68475475
- ufficiogruppi@trenitalia.it
- Website
- trenitalia.com
Train from Milano Centrale to Mannheim Hbf
- Ave. Duration
- 6h 48m
- Frequency
- Once daily
- Estimated price
- €120–180
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €120–180
- 2nd Class
- €120–160
- Phone
- +49 30 2970
- Website
- bahn.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 1h 17m
- Frequency
- Hourly
- Estimated price
- €13–19
- Website
- https://int.bahn.de/en
- Phone
- 0621 8301200
- Website
- suewex.de
Train from Mannheim, Hauptbahnhof to Mainz, Römisches Theater
- Ave. Duration
- 57 min
- Frequency
- 5 times a week
- Estimated price
- €14–20
- Schedules at
- suewex.de
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Palermo Via Tommaso Fazello to Milano, San Donato M3
- Ave. Duration
- 19h 10m
- Frequency
- Once a week
- Estimated price
- €55–85
- Schedules at
- autoservizisalemi.it
Bus from Palermo to Milano, Autostazione Lampugnano
- Ave. Duration
- 19h 50m
- Frequency
- Once a week
- Estimated price
- €60–90
- Schedules at
- autoservizisalemi.it
- Phone
- +39 080 3112335
- info@marinobus.it
- Website
- marinobus.it
Bus from Milan to Mannheim Central Bus Station
- Ave. Duration
- 11h 35m
- Frequency
- Twice a week
- Estimated price
- €50–70
- Website
- https://marinobus.it/en/
- Phone
- +49 30 300 137 300
- service@flixbus.com
- Website
- flixbus.fr
Bus from Palermo to Milano, Autostazione Lampugnano
- Ave. Duration
- 22h 15m
- Frequency
- Once daily
- Estimated price
- €60–180
- Website
- https://www.flixbus.co.uk
Bus from Milano, Autostazione Lampugnano to Mainz central train station
- Ave. Duration
- 12h 15m
- Frequency
- Twice daily
- Estimated price
- €35–100
- Website
- https://www.flixbus.co.uk
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Ferry from Messina Marittima to Villa S.Giovanni
- Ave. Duration
- 20 min
- Frequency
- Hourly
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39 010 209 4591
- booking@gnv.it
- Website
- gnv.it
Car ferry from Port of Palermo to Port of Genoa
- Ave. Duration
- 20h 45m
- Frequency
- Once daily
- Estimated price
- €60–140
- Website
- https://www.gnv.it/en
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More Questions & Answers
Palermo to Mainz bus services, operated by FlixBus, arrive at Milano, Autostazione Lampugnano station.
Palermo to Mainz train services, operated by Trenitalia Intercity, arrive at Roma Termini station.
Book your Palermo to Mainz bus tickets online with Omio and FlixBus.
There are 1121+ hotels available in Mainz.











































