There are 4 ways to get from Otay Mesa to Santa Ana by bus, tram, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Bus  •  3 h 25 min

  1. Take the bus from San Ysidro, Ca to Santa Ana, Ca 9486 / ...

$20 - $46

3 alternative options

Tram, train  •  3 h 51 min

  1. Take the tram from Iris Ave Station to America Plaza Station UC San Diego Blue Line
  2. Take the train from San Diego Santa Fe Depot to Santa Ana Regional Transportation Center Amtrak Pacific Surfliner

$34 - $70

Line 929 bus, bus  •  4 h 24 min

  1. Take the line 929 bus from Iris Avenue Transit Center to 12th & Imperial Transit Center 929 / ...
  2. Take the bus from San Diego to Santa Ana Tijuana-Reynosa / ...

$44 - $66

Drive  •  1 h 47 min

  1. Drive from Otay Mesa to Santa Ana 104.4 miles

$10 - $15

Questions & Answers

The cheapest way to get from Otay Mesa to Santa Ana is to drive which costs $10 - $15 and takes 1 h 47 min.

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The quickest way to get from Otay Mesa to Santa Ana is to drive which costs $10 - $15 and takes 1 h 47 min.

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No, there is no direct bus from Otay Mesa to Santa Ana. However, there are services departing from Otay Mesa Rd & Heritage Rd and arriving at Santa Ana, Ca via Iris Avenue Transit Center and San Ysidro, Ca. The journey, including transfers, takes approximately 3 h 25 min.

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The distance between Otay Mesa and Santa Ana is 96 miles. The road distance is 104.4 miles.

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The best way to get from Otay Mesa to Santa Ana without a car is to bus which takes 3 h 25 min and costs $20 - $50.

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It takes approximately 3 h 25 min to get from Otay Mesa to Santa Ana, including transfers.

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Otay Mesa to Santa Ana bus services, operated by Greyhound USA, depart from San Ysidro, Ca station.

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Otay Mesa to Santa Ana bus services, operated by Greyhound USA, arrive at Santa Ana, Ca station.

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Yes, the driving distance between Otay Mesa to Santa Ana is 104 miles. It takes approximately 1 h 47 min to drive from Otay Mesa to Santa Ana.

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There are 694+ hotels available in Santa Ana. Prices start at $77 USD per night.

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Map of how to get from Otay Mesa to Santa Ana.
Launch map view
  • Distance: 96.2 miles
  • Duration: 3 h 25 min

What companies run services between Otay Mesa, CA, USA and Santa Ana, CA, USA?

Greyhound USA operates a bus from Otay Mesa to Santa Ana hourly. Tickets cost $16 - $40 and the journey takes 2 h 20 min.

Train operators
San Diego Metro Transit
Phone
+1 619-233-3004
Website
sdmts.com
Tram from Iris Ave Station to America Plaza Station
Ave. Duration
38 min
Frequency
Every 15 minutes
Estimated price
$3
Schedules at
sdmts.com
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from San Diego Santa Fe Depot to Santa Ana Regional Transportation Center Amtrak
Ave. Duration
1 h 56 min
Frequency
Every 2 hours
Estimated price
$29 - $65
Website
amtrak.com
Coach Seat
$29 - $45
Flexi Coach Seat
$50 - $75
Business Coach Seat
$40 - $65
Room
$150 - $220
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from San Ysidro, Ca to Santa Ana, Ca
Ave. Duration
2 h 20 min
Frequency
Hourly
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
Greyhound Mexico
Phone
01-800 890 6821
Website
greyhound.com.mx
Bus from San Diego to Santa Ana
Ave. Duration
1 h 55 min
Frequency
Twice daily
Estimated price
$40 - $60
Schedules at
greyhound.com.mx

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