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There are 5 ways to get from Otay Mesa to Los Angeles by train, bus, night bus, car, tram or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train  •  4 h 53 min

  1. Take the train from San Diego Santa Fe Depot to Los Angeles Union Station Amtrak Pacific Surfliner

$35 - $80

Cheapest option

Bus  •  5 h 4 min

  1. Take the bus from San Ysidro, Ca to Los Angeles, Ca 9480 / ...

$23 - $50

3 alternative options

Night bus  •  5 h 10 min

  1. Take the night bus from San Diego Santa Fe Depot to Los Angeles Union Station Amtrak Amtrak Thruway Connecting Service

Drive  •  2 h 21 min

  1. Drive from Otay Mesa to Los Angeles 135.8 miles

$13 - $20

Line 905 bus, tram, fly  •  3 h 59 min

  1. Take the line 905 bus from Otay Mesa Rd & Heritage Rd to Iris Avenue Transit Center
  2. Take the tram from Iris Ave Station to America Plaza Station
  3. Fly from San Diego (SAN) to Los Angeles (LAX) SAN - LAX

$107 - $348

Questions & Answers

The cheapest way to get from Otay Mesa to Los Angeles is to drive which costs $13 - $20 and takes 2 h 21 min.

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The quickest way to get from Otay Mesa to Los Angeles is to drive which costs $13 - $20 and takes 2 h 21 min.

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No, there is no direct bus from Otay Mesa to Los Angeles. However, there are services departing from Otay Mesa Rd & Heritage Rd and arriving at Los Angeles, Ca via Iris Avenue Transit Center and San Ysidro, Ca. The journey, including transfers, takes approximately 5 h 4 min.

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The distance between Otay Mesa and Los Angeles is 126 miles. The road distance is 135.8 miles.

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The best way to get from Otay Mesa to Los Angeles without a car is to train which takes 4 h 53 min and costs $35 - $85.

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It takes approximately 4 h 53 min to get from Otay Mesa to Los Angeles, including transfers.

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Otay Mesa to Los Angeles bus services, operated by Greyhound USA, depart from San Ysidro, Ca station.

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The best way to get from Otay Mesa to Los Angeles is to train which takes 4 h 53 min and costs $35 - $85. Alternatively, you can bus, which costs $23 - $55 and takes 5 h 4 min.

Mode details

The quickest flight from San Diego Airport to Los Angeles Airport is the direct flight which takes 53 min.

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Otay Mesa to Los Angeles bus services, operated by Greyhound USA, arrive at Los Angeles, Ca station.

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Map of how to get from Otay Mesa to Los Angeles.
Launch map view
  • Distance: 126 miles
  • Duration: 4 h 53 min

What companies run services between Otay Mesa, CA, USA and Los Angeles, CA, USA?

Amtrak operates a train from Otay Mesa to Los Angeles every 2 hours. Tickets cost $30 - $75 and the journey takes 2 h 58 min. Alternatively, Greyhound USA operates a bus from Otay Mesa to Los Angeles hourly. Tickets cost $19 - $45 and the journey takes 3 h 55 min. Two other operators also service this route.

Airlines
Delta
Website
delta.com
Flights from San Diego to Los Angeles
Ave. Duration
59 min
When
Every day
Estimated price
$140 - $600
American Airlines
Website
aa.com
Flights from San Diego to Los Angeles
Ave. Duration
58 min
When
Every day
Estimated price
$110 - $600
United Airlines
Website
united.com
Flights from San Diego to Los Angeles
Ave. Duration
1 h 7 min
When
Every day
Estimated price
$110 - $650
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from San Diego Santa Fe Depot to Los Angeles Union Station Amtrak
Ave. Duration
2 h 58 min
Frequency
Every 2 hours
Estimated price
$30 - $75
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$55 - $85
Business Coach Seat
$50 - $75
Room
$170 - $240
San Diego Metro Transit
Phone
+1 619-233-3004
Website
sdmts.com
Tram from Iris Ave Station to America Plaza Station
Ave. Duration
38 min
Frequency
Every 15 minutes
Estimated price
$3
Schedules at
sdmts.com
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from San Ysidro, Ca to Los Angeles, Ca
Ave. Duration
3 h 55 min
Frequency
Hourly
Estimated price
$19 - $45
Website
greyhound.com
Economy
$19 - $30
Flexible
$35 - $45
Greyhound Mexico
Phone
01-800 890 6821
Website
greyhound.com.mx
Bus from San Ysidro to Los Angeles
Ave. Duration
3 h 40 min
Frequency
3 times a day
Estimated price
$40 - $60
Schedules at
greyhound.com.mx
ACN Autobuses
Phone
(01)66429904887
Email
clientes@acnautobuses.com
Website
acnautobuses.com
Bus from San Ysidro to Los Angeles
Ave. Duration
3 h 49 min
Frequency
Twice daily
Schedules at
acnautobuses.com
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Night bus from San Diego Santa Fe Depot to Los Angeles Union Station Amtrak
Ave. Duration
3 h 15 min
Frequency
Once daily
Website
amtrak.com

Want to know more about travelling around United States

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More Questions & Answers

Yes, the driving distance between Otay Mesa to Los Angeles is 136 miles. It takes approximately 2 h 21 min to drive from Otay Mesa to Los Angeles.

Get driving directions

American Airlines, United Airlines and Delta offer flights from San Diego Airport to Los Angeles Airport.

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There are 2539+ hotels available in Los Angeles. Prices start at $102 USD per night.

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