From Yodoyabashi subway to Shin-Osaka, train to Okayama, train to Nishiachi, then taxi to Mizushima-eki. 1 h 48 min ¥9757. From Osaka City Air Terminal bus to Kurashima then taxi to Mizushima-eki. 3 h 55 min ¥8086. From Osaka drive to Mizushima-eki. 2 h 28 min ¥2897.
Osaka Subway operates a train from Osaka to Mizushima-eki every 10 minutes. Tickets cost $2 - $3 and the journey takes 9 min. 2 other operators also service this route. Alternatively, Ryobi Express operates a bus from Osaka to Mizushima-eki every 3 hours. Tickets cost $32 and the journey takes 3 h 45 min.