There are 7 ways to get from Orlando to Great Smoky Mountains by plane, car, train or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Orlando to Knoxville, drive  •  7 h 11 min

  1. Fly from Orlando (MCO) to Knoxville (TYS) MCO - TYS
  2. Drive from Knoxville to Great Smoky Mountains

$168 - $862

Cheapest option

Bus, drive  •  21 h 25 min

  1. Take the bus from Orlando, Fl to Jacksonville, Fl
  2. Take the bus from Jacksonville, Fl to Winston Salem, Nc
  3. Take the bus from Winston Salem, Nc to Asheville, Nc
  4. Drive from Asheville, Nc to Great Smoky Mountains

$97 - $237

5 alternative options

Fly Orlando to Asheville, drive  •  5 h 32 min

  1. Fly from Orlando (MCO) to Asheville (AVL) MCO - AVL
  2. Drive from Asheville to Great Smoky Mountains

$240 - $444

Train to Orlando Sanford, fly to Knoxville, drive  •  5 h 28 min

  1. Take the train from Church Street to Sanford
  2. Fly from Orlando Sanford (SFB) to Knoxville (TYS) SFB - TYS
  3. Drive from Knoxville to Great Smoky Mountains

$104 - $229

Fly Orlando Sanford to Asheville, drive  •  5 h 35 min

  1. Fly from Orlando Sanford (SFB) to Asheville (AVL) SFB - AVL
  2. Drive from Asheville to Great Smoky Mountains

$141 - $421

Train, bus, drive  •  21 h 58 min

  1. Take the train from Orlando Amtrak to Cary Amtrak
  2. Take the train from Cary Amtrak to Greensboro Galyon Transportation Center
  3. Take the bus from Greensboro, Nc to Winston Salem, Nc
  4. Take the bus from Winston Salem, Nc to Asheville, Nc
  5. Drive from Asheville, Nc to Great Smoky Mountains

$153 - $388

Drive  •  10 h 57 min

  1. Drive from Orlando to Great Smoky Mountains 624.7 miles

$60 - $90

Questions & Answers

The cheapest way to get from Orlando to Great Smoky Mountains is to drive which costs $60 - $90 and takes 10 h 57 min.

More details

The quickest way to get from Orlando to Great Smoky Mountains is to train and fly and drive which costs $100 - $230 and takes 5 h 28 min.

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The distance between Orlando and Great Smoky Mountains is 505 miles. The road distance is 624.7 miles.

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It takes approximately 7 h 11 min to get from Orlando to Great Smoky Mountains, including transfers.

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There is no direct flight from Orlando Airport to Knoxville Airport. The quickest flight takes 3 h 32 min and has one stopover.

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Yes, the driving distance between Orlando to Great Smoky Mountains is 625 miles. It takes approximately 10 h 57 min to drive from Orlando to Great Smoky Mountains.

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United Airlines, American Airlines and Delta offer flights from Orlando Airport to Knoxville Airport.

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There are 1268+ hotels available in Great Smoky Mountains. Prices start at $69 USD per night.

More details

The best way to get from Orlando to Orlando Airport is to line 11 bus which takes 41 min and costs $3.

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Map of how to get from Orlando to Great Smoky Mountains.
Launch map view
  • Distance: 505.4 miles
  • Duration: 7 h 11 min

What companies run services between Orlando, FL, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Orlando to Great Smoky Mountains. However, you can take the line 11 bus to Oia Transfer Center, take the walk to Orlando airport, fly to Knoxville, then take the drive to Great Smoky Mountains. Alternatively, you can take the line 11 bus to Oia Transfer Center, take the walk to Orlando airport, fly to Asheville, then take the drive to Great Smoky Mountains.

Airlines
Delta
Website
delta.com
Flights from Orlando to Knoxville via Atlanta
Ave. Duration
3 h 55 min
When
Every day
Estimated price
$160 - $850
Flights from Orlando to Knoxville via Detroit
Ave. Duration
5 h 31 min
When
Every day
Estimated price
$220 - $1,000
Flights from Orlando to Asheville via Atlanta
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$470 - $850
American Airlines
Website
aa.com
Flights from Orlando to Knoxville via Charlotte
Ave. Duration
4 h 27 min
When
Every day
Estimated price
$180 - $850
Flights from Orlando to Knoxville via Philadelphia
Ave. Duration
5 h 26 min
When
Every day
Estimated price
$230 - $1,000
Flights from Orlando to Knoxville via Chicago O'Hare
Ave. Duration
5 h 35 min
When
Every day
Estimated price
$240 - $1,000
Flights from Orlando to Knoxville via Dallas/Ft.Worth
Ave. Duration
5 h 57 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$260 - $1,000
Flights from Orlando to Asheville via Charlotte
Ave. Duration
3 h 55 min
When
Every day
Estimated price
$460 - $850
United Airlines
Website
united.com
Flights from Orlando to Knoxville via Washington Dulles
Ave. Duration
5 h 16 min
When
Every day
Estimated price
$220 - $1,000
Flights from Orlando to Knoxville via Houston
Ave. Duration
5 h 40 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$250 - $1,100
Flights from Orlando to Knoxville via Newark
Ave. Duration
5 h 57 min
When
Every day
Estimated price
$250 - $1,100
Allegiant Air
Website
allegiantair.com
Flights from Orlando Sanford to Knoxville
Ave. Duration
1 h 32 min
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$110 - $380
Flights from Orlando Sanford to Asheville
Ave. Duration
1 h 28 min
When
Monday, Wednesday and Friday
Estimated price
$110 - $380
Spirit Airlines
Website
spirit.com
Flights from Orlando to Asheville
Ave. Duration
1 h 42 min
When
Monday, Friday and Saturday
Estimated price
$85 - $400
Train operators
SunRail
Website
sunrail.com
Train from Church Street to Sanford
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$2 - $4
Schedules at
sunrail.com
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Orlando Amtrak to Cary Amtrak
Ave. Duration
12 h 36 min
Frequency
Once daily
Estimated price
$90 - $260
Website
amtrak.com
Coach Seat
$90 - $140
Flexi Coach Seat
$160 - $230
Business Coach Seat
$180 - $260
Room
$370 - $550
Train from Cary Amtrak to Greensboro Galyon Transportation Center
Ave. Duration
1 h 19 min
Frequency
4 times a day
Estimated price
$26 - $55
Website
amtrak.com
Coach Seat
$26 - $40
Flexi Coach Seat
$45 - $70
Business Coach Seat
$35 - $55
Room
$140 - $210
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Orlando, Fl to Jacksonville, Fl
Ave. Duration
2 h 30 min
Frequency
Every 30 minutes
Estimated price
$19 - $50
Website
greyhound.com
Economy
$19 - $30
Flexible
$35 - $50
Bus from Jacksonville, Fl to Winston Salem, Nc
Ave. Duration
12 h 30 min
Frequency
Hourly
Estimated price
$50 - $130
Website
greyhound.com
Economy
$50 - $80
Flexible
$95 - $130
Bus from Winston Salem, Nc to Asheville, Nc
Ave. Duration
2 h 55 min
Frequency
Every 2 hours
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $30
Flexible
$35 - $50
Bus from Greensboro, Nc to Winston Salem, Nc
Ave. Duration
45 min
Frequency
Hourly
Estimated price
$9 - $20
Website
greyhound.com
Economy
$9 - $14
Flexible
$16 - $20
Sunway Charters
Phone
+1 704-348-1200
Email
info@sunwaycharters.com
Website
sunwaycharters.com
Bus from Greensboro, Nc to Winston-Salem
Ave. Duration
40 min
Frequency
Twice daily
Schedules at
sunwaycharters.com

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