There are 6 ways to get from Orlando Airport (MCO) to Greenville by plane, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly to Greenville/Spartanburg  •  2 h 2 min

  1. Fly from Orlando (MCO) to Greenville/Spartanburg (GSP) MCO - GSP

$107 - $424

5 alternative options

Fly to Charlotte, bus  •  4 h 36 min

  1. Fly from Orlando (MCO) to Charlotte (CLT) MCO - CLT
  2. Take the bus from Charlotte, NC to Greenville, SC

Bus La Cubana  •  10 h 50 min

  1. Take the bus from Orlando RedCoach Station to Ocala RedCoach
  2. Take the bus from Ocala, FL to Greenville, SC Atlanta route

$226 - $245

Megabus, bus  •  13 h 39 min

  1. Take the Megabus from Orlando to Midtown Atlanta
  2. Take the bus from Doraville, GA to Greenville, SC

$113 - $136

Bus Greyhound USA  •  15 h 1 min

  1. Take the bus from Orlando, Fl to Atlanta, Ga 1154 / ...
  2. Take the bus from Doraville, GA to Greenville, SC

$132 - $220

Drive  •  8 h 56 min

  1. Drive from Orlando Airport (MCO) to Greenville 547.3 miles

$50 - $80

Questions & Answers

The distance between Orlando Airport (MCO) and Greenville is 451 miles. The road distance is 547.3 miles.

Get driving directions

The best way to get from Orlando Airport (MCO) to Greenville without a car is to bus which takes 10 h 50 min and costs .

More details

It takes approximately 2 h 2 min to get from Orlando Airport (MCO) to Greenville, including transfers.

More details

The best way to get from Orlando Airport (MCO) to Greenville is to fly which takes 2 h 2 min and costs . Alternatively, you can bus, which costs and takes 10 h 50 min.

Mode details

The quickest flight from Orlando Airport to Greenville/Spartanburg Airport is the direct flight which takes 1 h 45 min.

Search flights

Yes, the driving distance between Orlando Airport (MCO) to Greenville is 547 miles. It takes approximately 8 h 56 min to drive from Orlando Airport (MCO) to Greenville.

Get driving directions

Frontier Airlines, Southwest Airlines, Delta and American Airlines offer flights from Orlando Airport to Greenville/Spartanburg Airport.

Search flights

There are 83+ hotels available in Greenville. Prices start at $69 USD per night.

More details

Map of how to get from Orlando Airport (MCO) to Greenville.
Launch map view
  • Distance: 450.8 miles
  • Duration: 2 h 2 min

What companies run services between Orlando Airport (MCO), USA and Greenville, SC, USA?

Frontier Airlines, Southwest Airlines and two other airlines fly from Orlando Airport (MCO) to Greenville hourly. Alternatively, you can take a bus from Orlando Airport (MCO) to Greenville via Orlando RedCoach Station, Ocala, Ocala, FL, and Greenville, SC in around 10 h 50 min.

Airlines
American Airlines
Website
aa.com
Flights from Orlando to Greenville/Spartanburg via Charlotte
Ave. Duration
3 h 33 min
When
Every day
Estimated price
$150 - $750
Flights from Orlando to Charlotte
Ave. Duration
1 h 43 min
When
Every day
Estimated price
$170 - $700
Delta
Website
delta.com
Flights from Orlando to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 35 min
When
Every day
Estimated price
$140 - $750
Flights from Orlando to Charlotte via Atlanta
Ave. Duration
3 h 41 min
When
Every day
Estimated price
$160 - $850
Southwest Airlines
Website
southwest.com
Flights from Orlando to Greenville/Spartanburg via Atlanta
Ave. Duration
3 h 31 min
When
Every day
Estimated price
$160 - $700
Frontier Airlines
Website
flyfrontier.com
Flights from Orlando to Greenville/Spartanburg
Ave. Duration
1 h 45 min
When
Wednesday and Saturday
Estimated price
$75 - $380
Flights from Orlando to Charlotte
Ave. Duration
1 h 47 min
When
Monday, Wednesday, Friday and Saturday
Estimated price
$65 - $700
Bus operators
Wanda Coach
Phone
6466307186
Email
help@wandacoach.com
Website
wandacoach.com
Bus from Charlotte, NC to Greenville, SC
Ave. Duration
1 h 45 min
Frequency
Every 4 hours
Schedules at
wandacoach.com
Red Coach
Phone
+1 877 733 0724
Email
webtickets@redcoachusa.com
Website
redcoachusa.com
Bus from Orlando RedCoach Station to Ocala
Ave. Duration
1 h 5 min
Frequency
Hourly
Estimated price
$29 - $40
Book at
redcoachusa.com
First Class
$40 - $55
Business
$29 - $40
La Cubana
Phone
+1 305-541-1700
Website
lacubanabus.com
Bus from Ocala, FL to Greenville, SC
Ave. Duration
8 h 30 min
Frequency
Once daily
Estimated price
$159
Schedules at
lacubanabus.com
Pandora Bus
Website
pandorabus.com
Bus from Doraville, GA to Greenville, SC
Ave. Duration
2 h 15 min
Frequency
Every 4 hours
Estimated price
$60
Schedules at
pandorabus.com
Book at
search.gotobus.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Orlando, Fl to Atlanta, Ga
Ave. Duration
8 h 5 min
Frequency
Hourly
Estimated price
$45 - $120
Website
greyhound.com
Economy
$45 - $75
Flexible
$85 - $120

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.