FlixBus operates a bus from Nuremberg to Chemnitz 4 times a day. Tickets cost $14 - $24 and the journey takes 2 h 55 min. East West Eurolines also services this route 4 times a week. Alternatively, German Railways (DB) operates a train from Nuremberg to Chemnitz hourly. Tickets cost $40 and the journey takes 1 h 44 min. German Railways (DB) also services this route hourly.
From Nuremberg bus to Chemnitz. 2 h 55 min 56€. From Nürnberg Hbf train to Hof Hbf then train to Chemnitz Hbf. 3 h 48 min 61€. From Nuremberg rideshare to Chemnitz. 3 h 3 min 10€. From Nuremberg drive to Chemnitz. 2 h 10 min 31€.