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How to get fromNiagara Falls to St. Louisby bus, plane, train (Amtrak), bus (Greyhound), car or train

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There are 7 ways to get from Niagara Falls to St. Louis by bus, plane, train (Amtrak), bus (Greyhound), car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Lambert–St. Louis International Airport (STL)plane plane BUF - STL
    6h 38m
    $253–1,451

  2. Bus

    cheapest
    1. Take the bus from Buffalo, NY to Columbus - Mound Stbus bus Buffalo
    2. Take the bus from Columbus to St Louis Bus Stationbus bus Greyhound US0421
    19h 11m
    $102–212

  3. Train

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    18h 5m
    $183–497

  4. Drive 754.4 mi

    1. Drive from Niagara Falls to St. Louiscar car 754.4 mi
    13h 2m
    $138–199

  5. Bus to Rochester, fly

    1. Take the bus from Niagara Falls, NY to Rochester, NYbus bus
    2. Fly from Rochester (ROC) to Lambert–St. Louis International Airport (STL)plane plane ROC - STL
    7h 58m
    $223–1,159

  6. Train to Toronto Pearson International Airport, fly

    1. Take the train from Niagara Falls to Toronto Union Stationtrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Lambert–St. Louis International Airport (STL)plane plane YYZ - STL
    7h 47m
    $343–985

  7. Bus via Pittsburgh

    1. Take the bus from Buffalo to Pittsburghbus bus Fab530
    2. Take the bus from Pittsburgh Intermodal Station to St Louis Bus Stationbus bus Greyhound US0421
    23h 26m
    $142–372

Niagara Falls to St. Louis by train

Calendar14Weekly Trains
Duration18h 5mAverage Duration
Ticket$183Cheapest Price
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Questions & Answers

What companies run services between Niagara Falls, NY, USA and St. Louis, MO, USA?

You can take a train from Niagara Falls Amtrak Station to St. Louis via Buffalo Depew Station and Chicago Union Station in around 18h 5m. Alternatively, you can take a bus from Pine Avenue & Main Street to St Louis Bus Station via Buffalo, NY and Columbus in around 19h 11m.

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