There are 6 ways to get from Niagara Falls to St. Louis by plane, train, bus or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Buffalo  •  6 h 43 min

  1. Fly from Buffalo (BUF) to St. Louis (STL) BUF - STL

$193 - $432

Cheapest option

Bus Greyhound Canada  •  20 h 50 min

  1. Take the bus from Niagara Falls, ON to Toronto, ON 326
  2. Take the bus from Toronto, ON to Chicago - Amtrak
  3. Take the bus from Chicago, IL to St Louis, MO

$88 - $180

4 alternative options

Train to Toronto, fly  •  7 h 13 min

  1. Take the train from Niagara Falls to Toronto
  2. Fly from Toronto (YYZ) to St. Louis (STL) YYZ - STL

$208 - $568

Train  •  18 h 53 min

  1. Take the train from Niagara Falls Station to Buffalo
  2. Take the train from Buffalo Depew Station Amtrak to Chicago Union Station Amtrak
  3. Take the train from Chicago Union Station Amtrak to St. Louis Gateway Station Amtrak

$146 - $407

Bus Greyhound USA  •  21 h 12 min

  1. Take the bus from Buffalo, Ny to Erie, Pa
  2. Take the bus from Erie, Pa to Pittsburgh, Pa
  3. Take the bus from Pittsburgh, Pa to St Louis, Mo

$96 - $237

Drive  •  12 h 57 min

  1. Drive from Niagara Falls to St. Louis 766.4 miles

$75 - $110

Questions & Answers

The cheapest way to get from Niagara Falls to St. Louis is to drive which costs $75 - $110 and takes 12 h 57 min.

More details

The quickest way to get from Niagara Falls to St. Louis is to fly which costs $190 - $440 and takes 6 h 43 min.

More details

The distance between Niagara Falls and St. Louis is 662 miles. The road distance is 766.4 miles.

Get driving directions

It takes approximately 6 h 43 min to get from Niagara Falls to St. Louis, including transfers.

More details

No, there is no direct bus from Niagara Falls to St. Louis. However, there are services departing from Niagara Falls, ON and arriving at St Louis, MO via Toronto, ON and Chicago, IL. The journey, including transfers, takes approximately 20 h 50 min.

More details

No, there is no direct train from Niagara Falls station to St. Louis station. However, there are services departing from Niagara Falls Station and arriving at St. Louis Gateway Station Amtrak via Buffalo Depew Station Amtrak and Chicago Union Station Amtrak. The journey, including transfers, takes approximately 18 h 53 min.

More details

What companies run services between Niagara Falls, NY, USA and St. Louis, MO, USA?

Delta, Southwest Airlines and two other airlines fly from Niagara Falls to St. Louis hourly. Alternatively, you can take a train from Niagara Falls to St. Louis via Buffalo, Buffalo Depew Station Amtrak, and Chicago Union Station Amtrak in around 18 h 53 min.

Airlines
United Airlines
Website
united.com
Flights from Buffalo to St. Louis via Chicago O'Hare
Ave. Duration
4 h 20 min
When
Every day
Estimated price
$190 - $850
Flights from Buffalo to St. Louis via Washington Dulles
Ave. Duration
4 h 41 min
When
Every day
Estimated price
$190 - $850
Flights from Toronto to St. Louis
Ave. Duration
2 h 8 min
When
Every day
Estimated price
$210 - $2,400
Flights from Toronto to St. Louis via Chicago O'Hare
Ave. Duration
4 h 18 min
When
Every day
Estimated price
$220 - $1,100
Flights from Toronto to St. Louis via Washington Dulles
Ave. Duration
4 h 33 min
When
Every day
Estimated price
$220 - $1,100
Air Canada
Website
aircanada.com
Flights from Buffalo to St. Louis via Chicago O'Hare
Ave. Duration
4 h 20 min
When
Every day
Estimated price
$190 - $850
Flights from Toronto to St. Louis
Ave. Duration
2 h 8 min
When
Every day
Estimated price
$210 - $2,400
Flights from Toronto to St. Louis via Chicago O'Hare
Ave. Duration
4 h 26 min
When
Every day
Estimated price
$220 - $1,100
Southwest Airlines
Website
southwest.com
Flights from Buffalo to St. Louis via Chicago Midway
Ave. Duration
4 h 13 min
When
Monday to Saturday
Estimated price
$330 - $950
Flights from Buffalo to St. Louis via Baltimore
Ave. Duration
4 h 28 min
When
Every day
Estimated price
$330 - $950
Delta
Website
delta.com
Flights from Buffalo to St. Louis via Detroit
Ave. Duration
3 h 59 min
When
Every day
Estimated price
$180 - $700
Flights from Buffalo to St. Louis via Atlanta
Ave. Duration
4 h 50 min
When
Every day
Estimated price
$180 - $700
Flights from Toronto to St. Louis via Detroit
Ave. Duration
4 h 4 min
When
Every day
Estimated price
$220 - $1,100
American Airlines
Website
aa.com
Flights from Buffalo to St. Louis via Chicago O'Hare
Ave. Duration
4 h 10 min
When
Every day
Estimated price
$180 - $700
Flights from Buffalo to St. Louis via Reagan Washington
Ave. Duration
4 h 39 min
When
Every day
Estimated price
$180 - $700
Flights from Buffalo to St. Louis via Charlotte
Ave. Duration
4 h 47 min
When
Every day
Estimated price
$180 - $700
Flights from Toronto to St. Louis via Chicago O'Hare
Ave. Duration
4 h 1 min
When
Every day
Estimated price
$210 - $1,100
Train operators
VIA Rail
Phone
+1 1 888 842-7245
Website
viarail.ca
Train from Niagara Falls to Toronto
Ave. Duration
1 h 56 min
Frequency
Every 3 hours
Estimated price
$26 - $75
Website
viarail.ca
Escape
$26 - $40
Economy
$30 - $50
Economy Plus
$55 - $75
Business
$45 - $70
Business Plus/Sleeper
$85 - $130
Train from Niagara Falls Station to Buffalo
Ave. Duration
52 min
Frequency
Every 3 hours
Estimated price
$21 - $60
Website
viarail.ca
Escape
$21 - $30
Economy
$25 - $35
Economy Plus
$40 - $60
Business
$30 - $50
Business Plus/Sleeper
$65 - $90
GO Transit
Website
gotransit.com
Train from Niagara Falls GO to Union Station
Ave. Duration
2 h 4 min
Frequency
Once daily
Estimated price
$11 - $15
Schedules at
gotransit.com
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Niagara Falls Amtrak to Buffalo Depew Station Amtrak
Ave. Duration
48 min
Frequency
4 times a day
Estimated price
$22 - $45
Website
amtrak.com
Coach Seat
$22 - $35
Flexi Coach Seat
$35 - $60
Business Coach Seat
$29 - $45
Room
$130 - $190
Train from Buffalo Depew Station Amtrak to Chicago Union Station Amtrak
Ave. Duration
10 h 31 min
Frequency
Twice daily
Estimated price
$75 - $220
Website
amtrak.com
Coach Seat
$75 - $120
Flexi Coach Seat
$140 - $200
Business Coach Seat
$150 - $220
Room
$330 - $460
Train from Chicago Union Station Amtrak to St. Louis Gateway Station Amtrak
Ave. Duration
5 h 30 min
Frequency
Every 4 hours
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Megabus Canada
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Niagara Falls, On to Toronto, On
Ave. Duration
1 h 50 min
Frequency
Hourly
Estimated price
$14 - $35
Website
greyhound.com
Economy
$14 - $21
Flexible
$25 - $35
Bus from Buffalo, Ny to Erie, Pa
Ave. Duration
1 h 55 min
Frequency
Every 30 minutes
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$27 - $35
Bus from Erie, Pa to Pittsburgh, Pa
Ave. Duration
3 h 35 min
Frequency
Hourly
Estimated price
$20 - $50
Website
greyhound.com
Economy
$20 - $35
Flexible
$35 - $50
Bus from Pittsburgh, Pa to St Louis, Mo
Ave. Duration
13 h 25 min
Frequency
Hourly
Estimated price
$60 - $150
Website
greyhound.com
Economy
$60 - $100
Flexible
$110 - $150
Greyhound Canada
Phone
+1 1-800-661-8747
Email
Canada.info@greyhound.ca
Website
greyhound.ca
Bus from Toronto, ON to Chicago - Amtrak
Ave. Duration
11 h 35 min
Frequency
Once daily
Estimated price
$45 - $120
Website
Greyhound.ca
Advanced Purchase
$45 - $70
Online Fare
$60 - $90
Standard Fare
$75 - $120
Refundable
$85 - $130

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.