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How to get fromNiagara Falls to Chicago Loopby bus, plane, train (Amtrak), bus (Greyhound, Amtrak), car, train, or bus (Flixbus)

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There are 9 ways to get from Niagara Falls to Chicago Loop by bus, plane, train (Amtrak), bus (Greyhound, Amtrak), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    4h 24m
    $187–322

  2. Drive  518.2 mi

    cheapest
    1. Drive from Niagara Falls to Chicago Loopcar car 518.2 mi
    8h 46m
    $89–128

  3. Train

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train Maple Leaf / ...
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    12h 19m
    $299–593

  4. Bus via Brook Park

    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    2. Take the bus from Cleveland Bus Station to Toledo Bus Stopbus bus
    3. Take the bus from Toledo to Chicago Union Stationbus bus
    13h 24m

  5. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    4h 37m
    $177–312

  6. Train to Rochester, fly to Chicago O'Hare International Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    5h 42m
    $116–602

  7. Train to Rochester, fly to Chicago Midway International Airport

    1. Take the train from Niagara Falls Amtrak Station to Rochestertrain train
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    5h 35m
    $141–792

  8. Bus to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    7h 28m
    $383–970

  9. Bus

    1. Take the bus from Bus Terminal to Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floorbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Chicagobus bus
    18h 11m
    $98–160

Niagara Falls to Chicago Loop by train

Calendar14Weekly Trains
Duration12h 19mAverage Duration
Ticket$299Cheapest Price
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Comparing Your Travel Options

Map of how to get from Niagara Falls to Chicago Loop.ExpandLaunch map view
  • Distance: 509.5 mi
  • Duration: 4h 24m

What companies run services between Niagara Falls, NY, USA and Chicago Loop, IL, USA?

You can take a train from Niagara Falls Amtrak Station to Chicago Union Station via Buffalo Depew Station in around 12h 19m. Alternatively, you can take a bus from Pine Avenue & Main Street to Chicago Union Station via Ellicott Street & MTC Static, Buffalo, Cleveland Bus Station, and Toledo in around 13h 24m.

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