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How to get fromNiagara Falls to Chicagoby bus, plane, train (Amtrak), bus (Greyhound), car, train or bus (Flixbus)

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There are 8 ways to get from Niagara Falls to Chicago by bus, plane, train (Amtrak), bus (Greyhound), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    4h 47m
    $83–545

  2. Bus

    cheapest
    1. Take the bus from Buffalo to Cleveland Bus Stationbus bus Greyhound US0170
    2. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus Greyhound US0164
    14h 6m
    $58–137

  3. Train

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew Stationtrain train Maple Leaf / ...
    2. Take the train from Buffalo Depew Station to Chicago Union Stationtrain train Lake Shore Limited
    12h 19m
    $88–276

  4. Drive 520.6 mi

    1. Drive from Niagara Falls to Chicagocar car 520.6 mi
    8h 43m
    $95–138

  5. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    4h 36m
    $108–785

  6. Bus to Rochester, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara Falls, NY to Rochester, NYbus bus
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    6h 6m
    $132–551

  7. Train to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Canadian Border to Torontotrain train
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)plane plane YYZ - ORD
    7h 14m
    $223–528

  8. Bus via Detroit

    1. Take the bus from Niagara Falls, ON to Toronto Union Stationbus bus
    2. Take the bus from Toronto to Detroit Bus Stationbus bus
    3. Take the bus from Detroit Bus Station to Chicagobus bus
    18h 31m
    $79–239

Niagara Falls to Chicago by train

Calendar14Weekly Trains
Duration12h 19mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

What companies run services between Niagara Falls, NY, USA and Chicago, IL, USA?

You can take a train from Niagara Falls Amtrak Station to Chicago Union Station via Buffalo Depew Station in around 12h 19m. Alternatively, you can take a bus from Pine Avenue & Main Street to Chicago Bus Station via Ellicott Street & MTC Static, Buffalo, and Cleveland Bus Station in around 14h 6m.

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