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How to get fromNiagara Falls to Chicagoby bus, plane, train (Amtrak), bus (Greyhound), car, train or bus (Flixbus)

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There are 9 ways to get from Niagara Falls to Chicago by bus, plane, train (Amtrak), bus (Greyhound), car, train, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    best
    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)planeBUF - MDW
    4h 21m
    $108–685

  2. Bus

    cheapest
    1. Take the bus from Buffalo to Cleveland Bus StationbusGreyhound US0170
    2. Take the bus from Cleveland Bus Station to Chicago Bus StationbusGreyhound US0164
    14h 6m
    $59–162

  3. Train

    1. Take the train from Niagara Falls Amtrak Station to Buffalo Depew StationtrainMaple Leaf / ...
    2. Take the train from Buffalo Depew Station to Chicago Union StationtrainLake Shore Limited
    12h 19m
    $78–277

  4. Drive 520.6 mi

    1. Drive from Niagara Falls to Chicagocar520.6 mi
    8h 38m
    $95–138

  5. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Niagara Falls USA to Buffalo Niagara International Airportbus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)planeBUF - ORD
    4h 41m
    $83–525

  6. Bus to Rochester, fly to Chicago Midway International Airport

    1. Take the bus from Niagara Falls, NY to Rochester, NYbus
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)planeROC - MDW
    5h 31m
    $107–551

  7. Train to Toronto Pearson International Airport, fly to Chicago O'Hare International Airport

    1. Take the train from Canadian Border to Torontotrain
    2. Fly from Toronto Pearson International Airport (YYZ) to Chicago O'Hare International Airport (ORD)planeYYZ - ORD
    7h 14m
    $214–510

  8. Train to Toronto Island Airport, fly to Chicago Midway International Airport

    1. Take the train from Canadian Border to Torontotrain
    2. Fly from Toronto Island Airport (YTZ) to Chicago Midway International Airport (MDW)planeYTZ - MDW
    6h 55m
    $167–513

  9. Bus via Detroit

    1. Take the bus from Niagara Falls, ON to Toronto Union Stationbus
    2. Take the bus from Toronto to Detroit Bus Stationbus
    3. Take the bus from Detroit Bus Station to Chicagobus
    18h 31m
    $84–235

Niagara Falls to Chicago by train

Calendar14Weekly Trains
Duration12h 19mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

What companies run services between Niagara Falls, NY, USA and Chicago, IL, USA?

You can take a train from Niagara Falls Amtrak Station to Chicago Union Station via Buffalo Depew Station in around 12h 19m. Alternatively, you can take a bus from Pine Avenue & Main Street to Chicago Bus Station via Ellicott Street & MTC Static, Buffalo, and Cleveland Bus Station in around 14h 6m.

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Need to know: Greyhound

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