There are 6 ways to get from New Smyrna Beach to Key Largo by car, train, bus, bus (Greyhound), plane, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive, train, bus
best- Drive from New Smyrna Beach to Orlando
- Take the train from Orlando to Miami
- Take the bus from Miami Airport Station to Key Largo Bus Stop
7h 52m$39–268Bus via Fort Pierce South
- Take the bus from Edgewater to Fort Pierce
- Take the bus from Fort Pierce to Miami Airport
- Take the bus from Miami Airport Station to Key Largo Bus Stop
9h 8m$75–172Drive 305.3 mi
- Drive from New Smyrna Beach to Key Largo305.3 mi
5h 14m$56–81Bus, fly, shuttle
- Take the bus from Daytona International Speedway to Village Inn, Tampa
- Fly from Tampa (TPA) to Fort Lauderdale–Hollywood International Airport (FLL)TPA - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FL
9h 36m$228–351Bus (Greyhound)
- Take the bus from New Smyrna Beach to Miami Airport StationGreyhound US0710s
- Take the bus from Miami Airport Station to Key Largo Bus StopGreyhound US0720s
10h 21m$65–101Bus #2
- Take the bus from New Smyrna Beach to Miami Airport Station
- Take the bus from Dadeland South Metrorail Station to SW 344 St @ Park & Ride38 / ...
- Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largo301
11h 22m
Tampa (TPA) to Fort Lauderdale–Hollywood International Airport (FLL) flights
Questions & Answers
The cheapest way to get from New Smyrna Beach to Key Largo is to drive which costs $55 - $85 and takes 5h 14m.
The fastest way to get from New Smyrna Beach to Key Largo is to drive which takes 5h 14m and costs $55 - $85.
The distance between New Smyrna Beach and Key Largo is 359 miles. The road distance is 307.1 miles.
The best way to get from New Smyrna Beach to Key Largo without a car is to bus via Fort Pierce South which takes 9h 8m and costs $75 - $180.
It takes approximately 7h 52m to get from New Smyrna Beach to Key Largo, including transfers.
Yes, the driving distance between New Smyrna Beach to Key Largo is 307 miles. It takes approximately 5h 14m to drive from New Smyrna Beach to Key Largo.
There are 284+ hotels available in Key Largo.
What companies run services between New Smyrna Beach, FL, USA and Key Largo, FL, USA?
You can take a vehicle from New Smyrna Beach to Key Largo Bus Stop via Edgewater, Fort Pierce, Miami Airport, Miami International Airport, Miami, Airport Intermodal Station, and Miami Airport Station in around 9h 8m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- spirit.com
Flights from Tampa to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 7m
- When
- Every day
- Estimated price
- $35–110
- Website
- southwest.com
Flights from Tampa to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 7m
- When
- Every day
- Estimated price
- $25–180
- Website
- jetblue.com
Flights from Tampa to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 4m
- When
- Monday, Tuesday, Wednesday, Friday, Saturday, and Sunday
- Estimated price
- $25–180
- Phone
- +1 831-539-2901
- guestservices@gobrightline.com
- Website
- gobrightline.com
Train from Orlando to Miami
- Ave. Duration
- 3h 34m
- Frequency
- Every 3 hours
- Estimated price
- $15–230
- Book at
- https://www.gobrightline.com
- Smart
- $15–200
- Premium
- $65–230
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Miami Airport Station to Key Largo Bus Stop
- Ave. Duration
- 1h 30m
- Frequency
- Twice daily
- Estimated price
- $13–22
- Website
- https://www.greyhound.com/
Bus from Edgewater to Fort Pierce
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $30–65
- Website
- https://www.greyhound.com/
Bus from New Smyrna Beach to Miami Airport Station
- Ave. Duration
- 7h 45m
- Frequency
- Once daily
- Estimated price
- $40–65
- Website
- https://www.greyhound.com/
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Fort Pierce to Miami Airport
- Ave. Duration
- 2h 20m
- Frequency
- 3 times a day
- Estimated price
- $15–65
- Website
- https://www.redcoachusa.com
- Web
- $15–65
- Phone
- +1-727-545-2088
- Website
- escotbuslines.com
Bus from Daytona International Speedway to Village Inn, Tampa
- Ave. Duration
- 3h 21m
- Frequency
- On demand
- Estimated price
- $60
- Website
- https://escotbuslines.com/
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 45m
- Frequency
- 4 times a day
- Estimated price
- $100–140
- Website
- https://www.keysshuttle.com
- Phone
- +1 786-469-5675
- Website
- miamidade.gov
Bus from Dadeland South Metrorail Station to SW 344 St @ Park & Ride
- Ave. Duration
- 1h 12m
- Frequency
- Every 15 minutes
- Website
- https://www.miamidade.gov/global/transportation/home.page
Bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largo
- Ave. Duration
- 55 min
- Frequency
- Hourly
- Website
- https://www.miamidade.gov/global/transportation/home.page
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide













