• Our partners include:

  • Greyhound USA
  • VIA Rail
  • Amtrak
  • Acela Express
  • Megabus
  • SuperShuttle
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  • Airbnb
  • Expedia

There are 11 ways to get from New Orleans to South Carolina by plane, bus, car or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly New Orleans to Greenville/Spartanburg  •  5h 10m

  1. Fly from New Orleans (MSY) to Greenville/Spartanburg (GSP) MSY - GSP

$201 - $502

Cheapest option

Bus Megabus  •  16h 20m

  1. Take the bus from New Orleans to Marta Civic Center Station - Nb
  2. Take the bus from Atlanta GA to Columbia, SC
  3. Take the bus from Columbia, SC to Florence, SC

$84 - $123

9 alternative options

Fly New Orleans to Charleston  •  6h 8m

  1. Fly from New Orleans (MSY) to Charleston (CHS) MSY - CHS

$173 - $920

Fly New Orleans to Columbia  •  6h 26m

  1. Fly from New Orleans (MSY) to Columbia (CAE) MSY - CAE

$173 - $919

Fly New Orleans to Charlotte, bus  •  6h 24m

  1. Fly from New Orleans (MSY) to Charlotte (CLT) MSY - CLT
  2. Take the bus from Transit Center- Bay X to White Street Park and Ride

$167 - $385

Drive to Gulfport/Biloxi, fly to Charlotte, bus  •  5h 58m

  1. Drive from New Orleans to Gulfport/Biloxi
  2. Fly from Gulfport/Biloxi (GPT) to Charlotte (CLT) GPT - CLT
  3. Take the bus from Transit Center- Bay X to White Street Park and Ride

$243 - $1,319

Bus Greyhound USA  •  15h 38m

  1. Take the bus from New Orleans, La to Atlanta, Ga 1596 / ...
  2. Take the bus from Atlanta, GA to Florence, SC Atlanta

$87 - $181

Train, bus  •  18h 43m

  1. Take the train from New Orleans Union Passenger Terminal to Atlanta Peachtree Station Crescent
  2. Take the bus from Atlanta, GA to Florence, SC Atlanta

$116 - $274

Train, bus via Atlanta, Ga  •  19h 50m

  1. Take the train from New Orleans Union Passenger Terminal to Atlanta Peachtree Station Crescent
  2. Take the bus from Atlanta, Ga to Florence, SC Atlanta

$124 - $282

Train  •  26h 24m

  1. Take the train from New Orleans Union Passenger Terminal to Greensboro Amtrak Station
  2. Take the train from Greensboro Amtrak Station to Selma-Smithfield Amtrak Station
  3. Take the train from Selma-Smithfield Amtrak Station to Florence Amtrak Station

$178 - $480

Drive  •  12h 21m

  1. Drive from New Orleans to Florence 758.1 miles

$70 - $110

Questions & Answers

The cheapest way to get from New Orleans to South Carolina is to drive which costs $70 - $110 and takes 12h 21m.

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The quickest way to get from New Orleans to South Carolina is to fly which costs $200 - $500 and takes 5h 10m.

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No, there is no direct bus from New Orleans to South Carolina. However, there are services departing from New Orleans, La and arriving at Florence, SC via Peachtree St @ Alabama St and Atlanta, GA. The journey, including transfers, takes approximately 15h 38m.

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No, there is no direct train from New Orleans to South Carolina station. However, there are services departing from New Orleans Union Passenger Terminal and arriving at Florence Amtrak Station via Greensboro Amtrak Station and Selma-Smithfield Amtrak Station. The journey, including transfers, takes approximately 26h 24m.

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The distance between New Orleans and South Carolina is 625 miles. The road distance is 758.1 miles.

Get driving directions

The best way to get from New Orleans to South Carolina without a car is to bus which takes 15h 38m and costs $85 - $190.

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It takes approximately 5h 10m to get from New Orleans to South Carolina, including transfers.

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New Orleans to South Carolina bus services, operated by Greyhound USA, depart from New Orleans, La station.

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New Orleans to South Carolina train services, operated by Amtrak, depart from New Orleans Union Passenger Terminal station.

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The best way to get from New Orleans to South Carolina is to fly which takes 5h 10m and costs $200 - $500. Alternatively, you can bus, which costs $85 - $190 and takes 15h 38m, you could also train, which costs $170 - $480 and takes 26h 24m.

Mode details

Map of how to get from New Orleans to South Carolina.
Launch map view
  • Distance: 625.1 miles
  • Duration: 5h 10m

What companies run services between New Orleans, LA, USA and South Carolina, USA?

Southwest Airlines, Delta and two other airlines fly from New Orleans to Greenville hourly. Alternatively, you can take a bus from New Orleans to Florence via Atlanta, Ga, Peachtree St @ Alabama St, Peachtree St Sw @ Brotherton Transportation Mall, and Atlanta, GA in around 15h 38m.

Airlines
American Airlines
Website
aa.com
Flights from New Orleans to Greenville/Spartanburg via Charlotte
Ave. Duration
4h 3m
When
Every day
Estimated price
$190 - $650
Flights from New Orleans to Greenville/Spartanburg via Dallas/Ft.Worth
Ave. Duration
5h 13m
When
Every day
Estimated price
$190 - $650
Flights from New Orleans to Greenville/Spartanburg via Reagan Washington
Ave. Duration
5h 9m
When
Saturday
Estimated price
$190 - $650
Flights from New Orleans to Charleston via Charlotte
Ave. Duration
4h 18m
When
Every day
Estimated price
$190 - $900
Flights from New Orleans to Charleston via Reagan Washington
Ave. Duration
5h 11m
When
Monday to Saturday
Estimated price
$240 - $1,000
Flights from New Orleans to Columbia via Charlotte
Ave. Duration
4h 31m
When
Every day
Estimated price
$190 - $900
Flights from New Orleans to Columbia via Dallas/Ft.Worth
Ave. Duration
5h 2m
When
Every day
Estimated price
$240 - $1,000
Flights from New Orleans to Columbia via Philadelphia
Ave. Duration
5h 38m
When
Saturday
Estimated price
$260 - $1,100
Flights from New Orleans to Columbia via Reagan Washington
Ave. Duration
6h 33m
When
Every day
Estimated price
$240 - $1,000
Flights from New Orleans to Charlotte
Ave. Duration
1h 56m
When
Every day
Estimated price
$290 - $900
Flights from Gulfport/Biloxi to Charlotte
Ave. Duration
1h 55m
When
Every day
Estimated price
$390 - $2,700
Delta
Website
delta.com
Flights from New Orleans to Greenville/Spartanburg via Atlanta
Ave. Duration
3h 58m
When
Every day
Estimated price
$170 - $650
Flights from New Orleans to Charleston via Atlanta
Ave. Duration
3h 56m
When
Every day
Estimated price
$170 - $900
Flights from New Orleans to Columbia via Atlanta
Ave. Duration
3h 48m
When
Every day
Estimated price
$170 - $900
Flights from New Orleans to Charlotte via Atlanta
Ave. Duration
3h 54m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $900
Flights from Gulfport/Biloxi to Charlotte via Atlanta
Ave. Duration
4h 15m
When
Every day
Estimated price
$410 - $2,700
Southwest Airlines
Website
southwest.com
Flights from New Orleans to Greenville/Spartanburg via Atlanta
Ave. Duration
3h 54m
When
Every day
Estimated price
$160 - $700
Flights from New Orleans to Charleston via Nashville
Ave. Duration
4h 18m
When
Every day
Estimated price
$220 - $900
Flights from New Orleans to Charleston via Baltimore
Ave. Duration
4h 55m
When
Sunday
Estimated price
$270 - $1,100
Flights from New Orleans to Charleston via Houston Hobby Apt
Ave. Duration
5h
When
Saturday
Estimated price
$250 - $1,000
Flights from New Orleans to Charleston via Chicago Midway
Ave. Duration
5h 12m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$280 - $1,100
Flights from New Orleans to Charlotte via Nashville
Ave. Duration
3h 35m
When
Sunday
Estimated price
$360 - $750
United Airlines
Website
united.com
Flights from New Orleans to Greenville/Spartanburg via Houston
Ave. Duration
4h 44m
When
Every day
Estimated price
$230 - $700
Flights from New Orleans to Greenville/Spartanburg via Washington Dulles
Ave. Duration
4h 52m
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$230 - $700
Flights from New Orleans to Greenville/Spartanburg via Chicago O'Hare
Ave. Duration
5h 32m
When
Monday and Tuesday
Estimated price
$230 - $700
Flights from New Orleans to Charleston via Houston
Ave. Duration
5h 3m
When
Every day
Estimated price
$230 - $1,100
Flights from New Orleans to Charleston via Washington Dulles
Ave. Duration
5h 5m
When
Monday, Wednesday, Thursday, Friday and Sunday
Estimated price
$240 - $1,100
Flights from New Orleans to Columbia via Washington Dulles
Ave. Duration
4h 45m
When
Every day
Estimated price
$240 - $1,100
Flights from New Orleans to Columbia via Houston
Ave. Duration
5h 2m
When
Every day
Estimated price
$230 - $1,100
Flights from New Orleans to Columbia via Chicago O'Hare
Ave. Duration
6h 56m
When
Every day
Estimated price
$250 - $1,100
Flights from New Orleans to Charlotte via Washington Dulles
Ave. Duration
4h 41m
When
Monday, Wednesday, Thursday, Friday and Sunday
Estimated price
$220 - $750
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from New Orleans Union Passenger Terminal to Atlanta Peachtree Station
Ave. Duration
11h 35m
Frequency
Once daily
Estimated price
$75 - $220
Website
amtrak.com
Coach Seat
$75 - $120
Flexi Coach Seat
$130 - $200
Business Coach Seat
$150 - $220
Room
$330 - $460
Train from New Orleans Union Passenger Terminal to Greensboro Amtrak Station
Ave. Duration
19h 37m
Frequency
Once daily
Estimated price
$110 - $340
Website
amtrak.com
Coach Seat
$110 - $180
Flexi Coach Seat
$210 - $300
Business Coach Seat
$240 - $340
Room
$470 - $650
Train from Greensboro Amtrak Station to Selma-Smithfield Amtrak Station
Ave. Duration
2h 22m
Frequency
Once daily
Estimated price
$30 - $70
Website
amtrak.com
Coach Seat
$30 - $45
Flexi Coach Seat
$55 - $80
Business Coach Seat
$45 - $70
Room
$160 - $230
Train from Selma-Smithfield Amtrak Station to Florence Amtrak Station
Ave. Duration
2h 25m
Frequency
Once daily
Estimated price
$30 - $75
Website
amtrak.com
Coach Seat
$30 - $50
Flexi Coach Seat
$55 - $85
Business Coach Seat
$50 - $75
Room
$170 - $240
Bus operators
Charlotte Area Transit System
Phone
+1 704-336-7433
Email
telltransit@charlottenc.gov
Website
charlottenc.gov
Bus from Transit Center- Bay X to White Street Park and Ride
Ave. Duration
1h 12m
Frequency
3 times a day
Estimated price
$3 - $5
Schedules at
charlottenc.gov
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from New Orleans, La to Atlanta, Ga
Ave. Duration
9h
Frequency
Every 2 hours
Estimated price
$45 - $120
Website
greyhound.com
Economy
$45 - $80
Flexible
$90 - $120
South Eastern Stages
Phone
+1 877.836.7607 / 404.591.2750
Email
info@sestages.com
Website
southeasternstages.com
Bus from Atlanta, GA to Florence, SC
Ave. Duration
5h 30m
Frequency
Once daily
Estimated price
$35 - $60
Schedules at
southeasternstages.com
Bus from Columbia, SC to Florence, SC
Ave. Duration
1h 20m
Frequency
Once daily
Estimated price
$19 - $30
Schedules at
southeasternstages.com
Bus from Atlanta, Ga to Florence, SC
Ave. Duration
6h 55m
Frequency
3 times a day
Estimated price
$40 - $65
Schedules at
southeasternstages.com
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from New Orleans to Marta Civic Center Station - Nb
Ave. Duration
8h 45m
Frequency
Twice daily
Estimated price
$40 - $60
Book at
megabus.com
Bus from Atlanta GA to Columbia, SC
Ave. Duration
4h 15m
Frequency
Twice daily
Estimated price
$21 - $35
Book at
megabus.com

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More Questions & Answers

There is no direct flight from New Orleans Airport to Greenville/Spartanburg Airport. The quickest flight takes 3h 15m and has one stopover.

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New Orleans to South Carolina bus services, operated by South Eastern Stages, arrive at Florence, SC station.

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South Carolina is 1h ahead of New Orleans. It is currently 11:13 PM in New Orleans and 12:13 AM in South Carolina.

New Orleans to South Carolina train services, operated by Amtrak, arrive at Florence Amtrak Station.

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Yes, the driving distance between New Orleans to South Carolina is 758 miles. It takes approximately 12h 21m to drive from New Orleans to South Carolina.

Get driving directions

United Airlines, Southwest Airlines, Delta and American Airlines offer flights from New Orleans Airport to Greenville/Spartanburg Airport.

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Book your New Orleans to South Carolina train tickets online with Rome2rio.

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There are 19+ hotels available in South Carolina. Prices start at $49 USD per night.

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The best way to get from New Orleans to New Orleans Airport is to Bus which takes 38m and costs $1 - $17.

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