There are 5 ways to get from New Orleans to Knoxville by plane, car, bus or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from New Orleans  •  5 h 7 min

  1. Fly from New Orleans (MSY) to Knoxville (TYS) MSY - TYS

$256 - $687

Cheapest option

Bus  •  13 h 13 min

  1. Take the bus from New Orleans, La to Mobile, Al
  2. Take the bus from Mobile, Al to Atlanta, Ga
  3. Take the bus from Atlanta, Ga to Knoxville, Tn

$81 - $200

3 alternative options

Drive to Gulfport/Biloxi, fly  •  5 h 18 min

  1. Drive from New Orleans to Gulfport/Biloxi
  2. Fly from Gulfport/Biloxi (GPT) to Knoxville (TYS) GPT - TYS

$332 - $1,581

Train, bus, Megabus  •  16 h 25 min

  1. Take the train from New Orleans Union Passenger Terminal Amtrak to Birmingham Amtrak
  2. Take the bus from Birmingham, AL to Atlanta, GA - W Peachtree St @ Civic Center MARTA Station
  3. Take the Megabus from Atlanta GA to Knoxville

$96 - $214

Drive  •  9 h 59 min

  1. Drive from New Orleans to Knoxville 602.2 miles

$55 - $85

Questions & Answers

The cheapest way to get from New Orleans to Knoxville is to drive which costs $55 - $85 and takes 9 h 59 min.

More details

The quickest way to get from New Orleans to Knoxville is to fly which takes 5 h 7 min and costs $250 - $700.

More details

The distance between New Orleans and Knoxville is 880 km. The road distance is 964 km.

Get driving directions

It takes approximately 5 h 7 min to get from New Orleans to Knoxville, including transfers.

More details

No, there is no direct bus from New Orleans to Knoxville. However, there are services departing from New Orleans, La and arriving at Knoxville, Tn via Mobile, Al and Atlanta, Ga. The journey, including transfers, takes approximately 13 h 13 min.

More details

What companies run services between New Orleans, LA, USA and Knoxville, TN, USA?

Delta, American Airlines and United Airlines fly from New Orleans to Knoxville hourly. Alternatively, you can take a bus from New Orleans to Knoxville via Mobile, Al and Atlanta, Ga in around 13 h 13 min.

Airlines
Delta
Website
delta.com
Flights from New Orleans to Knoxville via Atlanta
Ave. Duration
4 h 12 min
When
Every day
Estimated price
$400 - $1,200
Flights from New Orleans to Knoxville via Detroit
Ave. Duration
5 h 5 min
When
Every day
Estimated price
$400 - $1,200
Flights from Gulfport/Biloxi to Knoxville via Atlanta
Ave. Duration
4 h 11 min
When
Every day
Estimated price
$270 - $1,500
American Airlines
Website
aa.com
Flights from New Orleans to Knoxville via Charlotte
Ave. Duration
4 h 24 min
When
Every day
Estimated price
$450 - $1,200
Flights from New Orleans to Knoxville via Dallas/Ft.Worth
Ave. Duration
5 h 11 min
When
Every day
Estimated price
$450 - $1,200
Flights from New Orleans to Knoxville via Chicago O'Hare
Ave. Duration
5 h
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$450 - $1,200
Flights from New Orleans to Knoxville via Reagan Washington
Ave. Duration
5 h 18 min
When
Every day
Estimated price
$450 - $1,200
Flights from Gulfport/Biloxi to Knoxville via Charlotte
Ave. Duration
3 h 56 min
When
Every day
Estimated price
$330 - $1,600
Flights from Gulfport/Biloxi to Knoxville via Dallas/Ft.Worth
Ave. Duration
5 h 28 min
When
Every day
Estimated price
$400 - $1,700
United Airlines
Website
united.com
Flights from New Orleans to Knoxville via Houston
Ave. Duration
4 h 55 min
When
Every day
Estimated price
$410 - $1,200
Flights from New Orleans to Knoxville via Washington Dulles
Ave. Duration
5 h 13 min
When
Every day
Estimated price
$410 - $1,200
Flights from Gulfport/Biloxi to Knoxville via Houston
Ave. Duration
5 h 28 min
When
Every day
Estimated price
$390 - $1,800
Flights from Gulfport/Biloxi to Knoxville via Houston, Washington Dulles
Ave. Duration
8 h 5 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$490 - $2,100
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from New Orleans Union Passenger Terminal Amtrak to Birmingham Amtrak
Ave. Duration
7 h 15 min
Frequency
Once daily
Estimated price
$55 - $160
Website
amtrak.com
Coach Seat
$55 - $90
Flexi Coach Seat
$100 - $150
Business Coach Seat
$110 - $160
Room
$260 - $360
Bus operators
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from New Orleans, La to Mobile, Al
Ave. Duration
2 h 20 min
Frequency
Every 15 minutes
Estimated price
$19 - $45
Website
greyhound.com
Economy
$19 - $30
Flexible
$35 - $45
Bus from Mobile, Al to Atlanta, Ga
Ave. Duration
5 h 40 min
Frequency
Every 30 minutes
Estimated price
$35 - $90
Website
greyhound.com
Economy
$35 - $60
Flexible
$65 - $90
Bus from Atlanta, Ga to Knoxville, Tn
Ave. Duration
4 h 45 min
Frequency
Every 30 minutes
Estimated price
$26 - $65
Website
greyhound.com
Economy
$26 - $45
Flexible
$45 - $65
Megabus
Phone
877-462-6342
Website
us.megabus.com
Bus from Birmingham, AL to Atlanta, GA - W Peachtree St @ Civic Center MARTA Station
Ave. Duration
3 h 5 min
Frequency
5 times a day
Estimated price
$15 - $26
Schedules at
us.megabus.com
Bus from Atlanta GA to Knoxville
Ave. Duration
4 h 5 min
Frequency
Twice daily
Estimated price
$22 - $35
Schedules at
us.megabus.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.