There are 8 ways to get from Natick to Ithaca by bus (Greyhound, Flixbus), train, bus, car, plane, or bus (Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus via Springfield
best- Take the bus from Framingham to Springfield Union Stationbus Greyhound US0270s
- Take the bus from Springfield Union Station to Ithacabus FlixBus 2691
9h 50m$59–156Train, bus
cheapest- Take the train from Framingham Amtrak to Utica Amtrak Stationtrain Lake Shore Limited
- Take the bus from Utica, NY to Ithaca, NYbus OurBus
12h 15m$52–186Drive 315.7 mi
- Drive from Natick to Ithacacar 315.7 mi
5h 55m$58–84Fly to Syracuse Hancock International Airport, bus
- Fly from Boston Logan Airport (BOS) to Syracuse Hancock International Airport (SYR)plane BOS - SYR
- Take the bus from Syracuse Airport, NY to Ithaca, NYbus
6h 21m$104–641Bus (Flixbus)
- Take the bus from Boston to Ithacabus FlixBus 2691
9h 55m$53–119Fly to Ithaca Tompkins Regional Airport
- Fly from Boston Logan Airport (BOS) to Ithaca Tompkins Regional Airport (ITH)plane BOS - ITH
7h 29m$54–366Fly to Rochester, bus
- Fly from Boston Logan Airport (BOS) to Rochester (ROC)plane BOS - ROC
- Take the bus from Rochester, NY to Ithaca, NYbus
7h 27m$214–646Fly to Buffalo Niagara International Airport, bus
- Fly from Boston Logan Airport (BOS) to Buffalo Niagara International Airport (BUF)plane BOS - BUF
- Take the bus from Buffalo Niagara International Airport to Ithacabus
8h 21m$189–1,066
Natick to Ithaca by train and bus
Questions & Answers
The cheapest way to get from Natick to Ithaca is to drive which costs $55 - $85 and takes 5h 55m.
The fastest way to get from Natick to Ithaca is to drive which takes 5h 55m and costs $55 - $85.
The distance between Natick and Ithaca is 371 miles. The road distance is 317.5 miles.
The best way to get from Natick to Ithaca without a car is to bus via Springfield which takes 9h 50m and costs $55 - $160.
It takes approximately 9h 50m to get from Natick to Ithaca, including transfers.
The best way to get from Natick to Ithaca is to bus via Springfield which takes 9h 50m and costs $55 - $160. Alternatively, you can fly, which costs $50 - $370 and takes 7h 29m.
Yes, the driving distance between Natick to Ithaca is 318 miles. It takes approximately 5h 55m to drive from Natick to Ithaca.
There are 71+ hotels available in Ithaca.
What companies run services between Natick, MA, USA and Ithaca, NY, USA?
You can take a train from Natick Center to Ithaca via Framingham, Framingham, and Springfield Union Station in around 9h 50m. Alternatively, Delta, United Airlines, and JetBlue Airways fly from Boston Logan Airport (BOS) to Ithaca Tompkins Regional Airport (ITH) every 4 hours.
- Website
- delta.com
Flights from Boston Logan Airport to Ithaca Tompkins Regional Airport via New York JFK
- Ave. Duration
- 4h 16m
- When
- Every day
- Estimated price
- $50–330
Flights from Boston Logan Airport to Rochester via New York La Guardia
- Ave. Duration
- 3h 59m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $85–500
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 3h 57m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $170–1,000
- Website
- jetblue.com
Flights from Boston Logan Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- $80–550
Flights from Boston Logan Airport to Rochester via New York JFK
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- $85–500
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 41m
- When
- Every day
- Estimated price
- $150–950
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York JFK
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- $170–1,000
- Website
- aa.com
Flights from Boston Logan Airport to Syracuse Hancock International Airport
- Ave. Duration
- 1h 26m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $80–550
Flights from Boston Logan Airport to Rochester
- Ave. Duration
- 1h 41m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $75–470
Flights from Boston Logan Airport to Buffalo Niagara International Airport
- Ave. Duration
- 1h 47m
- When
- Sunday
- Estimated price
- $150–950
Flights from Boston Logan Airport to Buffalo Niagara International Airport via New York La Guardia
- Ave. Duration
- 4h 3m
- When
- Sunday
- Estimated price
- $170–1,000
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Reagan Washington
- Ave. Duration
- 4h 16m
- When
- Friday
- Estimated price
- $200–1,100
- Website
- united.com
Flights from Boston Logan Airport to Ithaca Tompkins Regional Airport via Washington Dulles
- Ave. Duration
- 4h 29m
- When
- Every day
- Estimated price
- $70–380
Flights from Boston Logan Airport to Rochester via Newark
- Ave. Duration
- 4h 2m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $85–500
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Newark
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $170–1,000
- Website
- southwest.com
Flights from Boston Logan Airport to Rochester via Baltimore
- Ave. Duration
- 4h 5m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–550
Flights from Boston Logan Airport to Buffalo Niagara International Airport via Baltimore
- Ave. Duration
- 3h 50m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $200–1,100
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Framingham Amtrak to Utica Amtrak Station
- Ave. Duration
- 7h 20m
- Frequency
- Once daily
- Estimated price
- $30–120
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $30–70
- Coach Seat short notice purchase
- $35–120
- Business - advance purchase
- $45–220
- Business Class
- $80–280
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Framingham to Springfield Union Station
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $27–60
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Springfield Union Station to Ithaca
- Ave. Duration
- 6h
- Frequency
- 5 times a week
- Estimated price
- $30–90
- Schedules at
- flixbus.com
- Adult
- $30–90
Bus from Boston to Ithaca
- Ave. Duration
- 8h 10m
- Frequency
- 5 times a week
- Estimated price
- $50–110
- Schedules at
- flixbus.com
Bus from Buffalo Niagara International Airport to Ithaca
- Ave. Duration
- 3h 25m
- Frequency
- 6 times a week
- Estimated price
- $35–80
- Schedules at
- flixbus.com
- Phone
- +1-844-800-6828
- pr@ourbus.com
- Website
- ourbus.com
Bus from Utica, NY to Ithaca, NY
- Ave. Duration
- 2h 45m
- Frequency
- Twice a week
- Estimated price
- $20–60
- Website
- https://www.ourbus.com
Bus from Syracuse Airport, NY to Ithaca, NY
- Ave. Duration
- 1h 45m
- Frequency
- 5 times a week
- Estimated price
- $20–55
- Website
- https://www.ourbus.com
Bus from Rochester, NY to Ithaca, NY
- Ave. Duration
- 2h 30m
- Frequency
- 6 times a week
- Estimated price
- $20–60
- Website
- https://www.ourbus.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide









