There are 7 ways to get from Natchez to St. Louis by car, train, bus, plane, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive, train, bus
best- Drive from Natchez to Brookhaven Stationcar
- Take the train from Brookhaven Station to Jacksontrain
- Take the bus from Jackson to St Louis Bus Stationbus
14h 6m$89–217Drive, train, bus via Carbondale
cheapest- Drive from Natchez to Brookhaven Stationcar
- Take the train from Brookhaven Station to Carbondaletrain
- Take the bus from Carbondale to St. Louisbus
15h 44m$85–222Drive 571.8 mi
- Drive from Natchez to St. Louiscar 571.8 mi
10h 32m$105–151Fly from Natchez
- Fly from Natchez (HEZ) to Lambert–St. Louis International Airport (STL)plane HEZ - STL
8h 50m$161–736Drive to Baton Rouge Metropolitan Airport, fly
- Drive from Natchez to Baton-Rouge-Airport-BTRcar
- Fly from Baton Rouge Metropolitan Airport (BTR) to Lambert–St. Louis International Airport (STL)plane BTR - STL
6h 50m$148–725Taxi to Alexandria International Airport, fly
- Take the taxi from Natchez to Alexandria International Airport (AEX)taxi
- Fly from Alexandria International Airport (AEX) to Lambert–St. Louis International Airport (STL)plane AEX - STL
7h 24m$145–729Drive, train to Jackson/Vicksburg, fly
- Drive from Natchez to Brookhaven Stationcar
- Take the train from Brookhaven Station to Jacksontrain
- Fly from Jackson/Vicksburg (JAN) to Lambert–St. Louis International Airport (STL)plane JAN - STL
9h 24m$157–730
Natchez (HEZ) to Lambert–St. Louis International Airport (STL) flights
Questions & Answers
The cheapest way to get from Natchez to St. Louis is to drive and train and bus which costs $85 - $220 and takes 14h 6m.
The fastest way to get from Natchez to St. Louis is to drive and fly which takes 6h 50m and costs $140 - $750.
The distance between Natchez and St. Louis is 625 miles. The road distance is 575.1 miles.
It takes approximately 14h 6m to get from Natchez to St. Louis, including transfers.
Yes, the driving distance between Natchez to St. Louis is 575 miles. It takes approximately 10h 32m to drive from Natchez to St. Louis.
There are 353+ hotels available in St. Louis.
What companies run services between Natchez, MS, USA and St. Louis, MO, USA?
United Airlines flies from Natchez (HEZ) to Lambert–St. Louis International Airport (STL) once daily.
- Website
- aa.com
Flights from Baton Rouge Metropolitan Airport to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 30m
- When
- Every day
- Estimated price
- $130–700
Flights from Baton Rouge Metropolitan Airport to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 6h 49m
- When
- Every day
- Estimated price
- $160–800
Flights from Alexandria International Airport to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 1m
- When
- Every day
- Estimated price
- $120–700
Flights from Jackson/Vicksburg to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 7m
- When
- Every day
- Estimated price
- $130–700
Flights from Jackson/Vicksburg to Lambert–St. Louis International Airport via Charlotte
- Ave. Duration
- 7h 22m
- When
- Every day
- Estimated price
- $150–750
- Website
- delta.com
Flights from Baton Rouge Metropolitan Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 4h 33m
- When
- Every day
- Estimated price
- $130–700
Flights from Alexandria International Airport to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 50m
- When
- Every day
- Estimated price
- $140–700
Flights from Jackson/Vicksburg to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 5m
- When
- Every day
- Estimated price
- $120–700
- Website
- united.com
Flights from Natchez to Lambert–St. Louis International Airport via Houston
- Ave. Duration
- 7h 50m
- When
- Every day
- Estimated price
- $130–700
Flights from Baton Rouge Metropolitan Airport to Lambert–St. Louis International Airport via Houston
- Ave. Duration
- 5h 27m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $130–700
Flights from Jackson/Vicksburg to Lambert–St. Louis International Airport via Houston
- Ave. Duration
- 6h 42m
- When
- Every day
- Estimated price
- $140–750
- Website
- southwest.com
Flights from Jackson/Vicksburg to Lambert–St. Louis International Airport via Houston Hobby Apt
- Ave. Duration
- 6h 52m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $140–750
Flights from Jackson/Vicksburg to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 5h 20m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $100–600
Flights from Jackson/Vicksburg to Lambert–St. Louis International Airport via Baltimore
- Ave. Duration
- 7h 20m
- When
- Monday, Thursday, Friday, and Sunday
- Estimated price
- $200–900
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Brookhaven Station to Jackson
- Ave. Duration
- 1h 32m
- Frequency
- Once daily
- Estimated price
- $7–60
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $16–27
- Coach Seat short notice purchase
- $7–60
- Business - advance purchase
- $9–80
- Business Class
- $16–170
Train from Brookhaven Station to Carbondale
- Ave. Duration
- 11h 15m
- Frequency
- Once daily
- Estimated price
- $50–170
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $50–130
- Coach Seat short notice purchase
- $60–170
- Business - advance purchase
- $85–370
- Business Class
- $140–390
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Jackson to St Louis Bus Station
- Ave. Duration
- 10h 5m
- Frequency
- Once daily
- Estimated price
- $70–140
- Website
- https://www.greyhound.com/
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Carbondale to St. Louis
- Ave. Duration
- 2h
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Carbondale to St. Louis
- Ave. Duration
- 2h 10m
- Frequency
- Once daily
- Estimated price
- $23–35
- Schedules at
- flixbus.com
- Ave. Duration
- 1h 51m
- Estimated price
- $22–26
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