There are 6 ways to get from Mytilene to Syracuse by plane, bus, car ferry, ferry, train, or busferry
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly, bus
best- Fly from Mytilene International Airport Odysseas Elytis (MJT) to Catania–Fontanarossa Airport (CTA)MJT - CTA
- Take the bus from Catania Airport to Siracusa - v.le Scala Greca
5h 24m€77–267Car ferry, bus, ferry
- Take the car ferry from Mytilene to Port of Thessaloniki
- Take the bus from Thessaloniki Macedonia KTEL Bus Station to Igoumenitsa
- Take the ferry from Port of Igoumenitsa to Porto di Brindisi
- Take the bus from Brindisi to Siracusa - Corso Umberto
34h 52m€201–378Car ferry, bus, train
- Take the car ferry from Mytilene to Port of Thessaloniki
- Take the bus from Thessaloniki Macedonia KTEL Bus Station to Kozani
- Take the bus from Kozani to Elbasan
- Take the bus from Elbasan to Roma, Autostazione Tiburtina
- Take the train from Roma Tiburtina to SiracusaIc
38h 40mCar ferry, bus, bus and ferry
- Take the car ferry from Mytilene to Port of Thessaloniki
- Take the bus from Thessaloníki to Vlorë
- Take the busferry from Vlorë to Catania Via D'Amico
- Take the bus from Catania Via Archimede to Siracusa - Von Platen
40h 37mFerry, bus, bus and ferry, train
- Take the ferry from Mytilene to ThessalonikiBsf
- Take the bus from Thessaloníki to Vlorë
- Take the busferry from Vlorë to Messina - Piazza della Repubblica
- Take the train from Messina Centrale to SiracusaRe
42h 46mFerry, bus, bus and ferry
- Take the ferry from Mytilene to ThessalonikiBsf
- Take the bus from Thessaloníki to Vlore , station
- Take the busferry from Vlorë to Catania Via D'Amico
- Take the bus from Catania Via Archimede to Siracusa - Von Platen
43h 7m
Mytilene International Airport Odysseas Elytis (MJT) to Catania–Fontanarossa Airport (CTA) flights
Questions & Answers
The cheapest way to get from Mytilene to Syracuse is to fly and bus which costs €75 - €270 and takes 5h 24m.
The fastest way to get from Mytilene to Syracuse is to fly and bus which takes 5h 24m and costs €75 - €270.
The distance between Mytilene and Syracuse is 1088 km.
The best way to get from Mytilene to Syracuse without a car is to car ferry and bus and ferry which takes 34h 52m and costs €200 - €380.
It takes approximately 5h 24m to get from Mytilene to Syracuse, including transfers.
Syracuse is 1h behind Mytilene. It is currently 11:28 PM in Mytilene and 10:28 PM in Syracuse.
There are 2861+ hotels available in Syracuse.
What companies run services between Mytilene, Greece and Syracuse, Italy?
There is no direct connection from Mytilene to Syracuse. However, you can take the taxi to Mytilene International Airport Odysseas Elytis (MJT) airport, fly to Catania–Fontanarossa Airport (CTA), walk to Catania Airport, then take the bus to Siracusa - v.le Scala Greca. Alternatively, you can take a car ferry from Mytilene to Siracusa - Corso Umberto via Port of Thessaloniki, Thessaloniki Macedonia KTEL Bus Station, Igoumenitsa, Port of Igoumenitsa, Porto di Brindisi, Brindisi - Costa Morena, Brindisi - p.zza Crispi, and Brindisi in around 34h 52m.
Transport is disrupted due to the Russia-Ukraine war. Read more
- Website
- en.aegeanair.com
Flights from Mytilene International Airport Odysseas Elytis to Catania–Fontanarossa Airport via Athens
- Ave. Duration
- 5h 35m
- When
- Thursday and Sunday
- Estimated price
- €70–260
- Website
- ryanair.com
Flights from Mytilene International Airport Odysseas Elytis to Catania–Fontanarossa Airport via Athens
- Ave. Duration
- 4h
- When
- Monday
- Estimated price
- €65–250
- Phone
- +39 06 68475475
- Website
- trenitalia.com
Train from Roma Tiburtina to Siracusa
- Ave. Duration
- 11h 48m
- Frequency
- Twice a week
- Estimated price
- €45–65
- Website
- https://www.trenitalia.com/en.html
- 2nd Class
- €45–65
Train from Messina Centrale to Siracusa
- Ave. Duration
- 2h 38m
- Frequency
- Twice daily
- Estimated price
- €15–21
- Website
- https://www.trenitalia.com/en.html
- Phone
- +39.06.5210550
- Website
- trenitalia.com
Train from Roma Tiburtina to Siracusa
- Ave. Duration
- 12h 6m
- Frequency
- Twice a week
- Estimated price
- €40–160
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €110–160
Train from Messina Centrale to Siracusa
- Ave. Duration
- 2h 45m
- Frequency
- Every 4 hours
- Estimated price
- €10–35
- Website
- https://www.trenitalia.com/en.html
- 1st Class
- €23–35
- Phone
- +39 0935 22 460
- Website
- interbus.it
Bus from Catania Airport to Siracusa - v.le Scala Greca
- Ave. Duration
- 55 min
- Frequency
- Hourly
- Estimated price
- €4–7
- Schedules at
- interbus.it
Bus from Catania Via Archimede to Siracusa - Von Platen
- Ave. Duration
- 1h 14m
- Frequency
- Hourly
- Estimated price
- €5–8
- Schedules at
- interbus.it
- Phone
- +30 2665 0 22309
- info@ktel-thesprotias.gr
- Website
- ktel-thesprotias.gr
Bus from Thessaloniki Macedonia KTEL Bus Station to Igoumenitsa
- Ave. Duration
- 5h
- Frequency
- Twice daily
- Estimated price
- €35–55
- Schedules at
- ktel-thesprotias.gr
- Book at
- ktelbus.gr
- Phone
- +39 0912742800
- info@saistrasporti.it
- Website
- saistrasporti.it
Bus from Brindisi to Siracusa - Corso Umberto
- Ave. Duration
- 9h 15m
- Frequency
- Twice daily
- Estimated price
- €30–45
- Website
- https://saistrasporti.it/en-US
- Phone
- +30 2461034454
- info@ktelkozanis.gr
- Website
- ktelkozanis.gr
Bus from Thessaloniki Macedonia KTEL Bus Station to Kozani
- Ave. Duration
- 1h 45m
- Frequency
- Every 3 hours
- Schedules at
- ktelkozanis.gr
- Book at
- ktelkozanis.gr
- Phone
- +355 67 604 2191
- Website
- facebook.com
Bus from Kozani to Elbasan
- Ave. Duration
- 3h 56m
- Frequency
- Once daily
- Schedules at
- autobus.al
- Phone
- +393293958604
- info@pistoiaviaggi.com
- Website
- pistoia-viaggi.it
Bus from Elbasan to Roma, Autostazione Tiburtina
- Ave. Duration
- 9h 48m
- Frequency
- Once a week
- Schedules at
- pistoia-viaggi.it
Busferry from Vlorë to Catania Via D'Amico
- Ave. Duration
- 19h 50m
- Frequency
- Once a week
- Schedules at
- pistoia-viaggi.it
Busferry from Vlorë to Messina - Piazza della Repubblica
- Ave. Duration
- 16h 56m
- Frequency
- Once a week
- Schedules at
- pistoia-viaggi.it
- Phone
- +30 2310241545
- crazy.holidays.tours@gmail.com
- Website
- crazyholidays.gr
Bus from Thessaloníki to Vlorë
- Ave. Duration
- 9h 45m
- Frequency
- Once daily
- Estimated price
- €40–70
- Website
- https://www.crazyholidays.gr/root.en.aspx
- Phone
- +355 69 661 4303
- likospartak@gmail.com
- Website
- likokostatours.weebly.com
Bus from Thessaloníki to Vlore , station
- Ave. Duration
- 9h 16m
- Frequency
- Once daily
- Schedules at
- facebook.com
- Phone
- +30 210 4121001
- info@seajets.gr
- Website
- seajets.com
Car ferry from Mytilene to Port of Thessaloniki
- Ave. Duration
- 7h 10m
- Frequency
- Once a week
- Estimated price
- €85–210
- Website
- https://www.seajets.com/
- Deck Fare Economy
- €85–130
- Deck Fare Economy & Car less than 4.25m
- €150–210
- Phone
- +39.081.496.444
- info@grimaldi.napoli.it
- Website
- grimaldi-lines.com
Ferry from Port of Igoumenitsa to Porto di Brindisi
- Ave. Duration
- 9h
- Frequency
- Twice daily
- Estimated price
- €40–65
- Website
- https://www.grimaldi-lines.com/en/
Ferry from Mytilene to Thessaloniki
- Ave. Duration
- 10h 5m
- Frequency
- Once a week
- Estimated price
- €40–110
- Website
- https://www.bluestarferries.com/en-gb/
- Economy
- €40–60
- 2 Bed Inside Cabin
- €70–90
- 4 Bed Outside Cabin
- €65–85
- 2 Bed Lux Cabin
- €90–110
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Travelling by boat in Italy
Read the travel guide
































