There are 7 ways to get from Myrtle Beach to Sebastian by plane, bus, train, shuttle, car, or bus (Greyhound, Flixbus)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Melbourne International Airport
best- Fly from Myrtle Beach (MYR) to Melbourne International Airport (MLB)plane MYR - MLB
4h 23m$157–479Drive 528.4 mi
cheapest- Drive from Myrtle Beach to Sebastiancar 528.4 mi
9h 33m$97–140Bus, train
- Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus
- Take the train from Charleston Amtrak Station to Jacksonvilletrain
- Take the bus from Jacksonville to Sebastianbus
14h 54m$213–344Bus, train, shuttle
- Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus
- Take the train from Charleston Amtrak Station to Delandtrain
- Take the train from DeLand to Sand Lake Roadtrain
- Take a shuttle bus from Orlando Airport to Sebastian, FL - BP
15h 33m$302–458Fly to Vero Beach Municipal Airport
- Fly from Myrtle Beach (MYR) to Vero Beach Municipal Airport (VRB)plane MYR - VRB
5h 21m$127–459Fly to Orlando, shuttle
- Fly from Myrtle Beach (MYR) to Orlando (MCO)plane MYR - MCO
- Take a shuttle bus from Orlando Airport to Sebastian, FL - BP
4h 20m$202–329Bus
- Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus
- Take the bus from Fayetteville Bus Station to Jacksonvillebus
- Take the bus from Jacksonville to Sebastianbus
17h 21m$152–230
Myrtle Beach (MYR) to Melbourne International Airport (MLB) flights
Comparing Your Travel Options
The cheapest way to get from Myrtle Beach to Sebastian is to drive which costs $95 - $140 and takes 9h 33m.
The fastest way to get from Myrtle Beach to Sebastian is to fly and shuttle which takes 4h 20m and costs $200 - $330.
No, there is no direct bus from Myrtle Beach station to Sebastian. However, there are services departing from Myrtle Beach Bus Station and arriving at Sebastian via Fayetteville Bus Station and Jacksonville. The journey, including transfers, takes approximately 17h 21m.
The distance between Myrtle Beach and Sebastian is 427 miles. The road distance is 531.5 miles.
The best way to get from Myrtle Beach to Sebastian without a car is to bus and train which takes 14h 54m and costs $210 - $350.
It takes approximately 4h 23m to get from Myrtle Beach to Sebastian, including transfers.
Myrtle Beach to Sebastian bus services, operated by Greyhound USA, depart from Myrtle Beach Bus Station.
The best way to get from Myrtle Beach to Sebastian is to fly which takes 4h 23m and costs $150 - $480. Alternatively, you can bus, which costs $150 - $230 and takes 17h 21m.
Myrtle Beach to Sebastian bus services, operated by Greyhound USA, arrive at Fayetteville Bus Station.
Yes, the driving distance between Myrtle Beach to Sebastian is 531 miles. It takes approximately 9h 33m to drive from Myrtle Beach to Sebastian.
What companies run services between Myrtle Beach, SC, USA and Sebastian, FL, USA?
Delta, American Airlines, and Allegiant Air fly from Myrtle Beach (MYR) to Melbourne International Airport (MLB) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Sebastian via Fayetteville Bus Station, Jacksonville, and Sebastian in around 17h 21m.
- Website
- aa.com
Flights from Myrtle Beach to Melbourne International Airport via Charlotte
- Ave. Duration
- 4h 49m
- When
- Every day
- Estimated price
- $65–370
Flights from Myrtle Beach to Vero Beach Municipal Airport via Charlotte
- Ave. Duration
- 5h 32m
- When
- Monday, Wednesday, Thursday, Friday, Saturday, and Sunday
- Estimated price
- $65–380
Flights from Myrtle Beach to Orlando via Charlotte
- Ave. Duration
- 4h 2m
- When
- Every day
- Estimated price
- $70–410
- Website
- delta.com
Flights from Myrtle Beach to Melbourne International Airport via Atlanta
- Ave. Duration
- 4h 4m
- When
- Every day
- Estimated price
- $70–390
Flights from Myrtle Beach to Orlando via Atlanta
- Ave. Duration
- 4h 3m
- When
- Every day
- Estimated price
- $75–420
- Website
- flybreeze.com
Flights from Myrtle Beach to Vero Beach Municipal Airport via Washington Dulles
- Ave. Duration
- 6h 6m
- When
- Saturday
- Estimated price
- $160–950
Flights from Myrtle Beach to Orlando
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- $100–200
- Website
- allegiantair.com
Flights from Myrtle Beach to Melbourne International Airport via Pittsburgh
- Ave. Duration
- 4h 31m
- When
- Sunday
- Estimated price
- $100–490
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Charleston Amtrak Station to Jacksonville
- Ave. Duration
- 4h 28m
- Frequency
- Once daily
- Estimated price
- $130–220
- Website
- Amtrak
Train from Charleston Amtrak Station to Deland
- Ave. Duration
- 6h 54m
- Frequency
- Once daily
- Estimated price
- $190–310
- Website
- Amtrak
- Phone
- +1 855-724-5411
- info@sunrail.com
- Website
- SunRail
Train from DeLand to Sand Lake Road
- Ave. Duration
- 1h 23m
- Frequency
- Hourly
- Estimated price
- $3–5
- Website
- SunRail
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Myrtle Beach Bus Station to Charleston Bus Station
- Ave. Duration
- 2h 25m
- Frequency
- Twice daily
- Estimated price
- $17–26
- Website
- Greyhound
Bus from Jacksonville to Sebastian
- Ave. Duration
- 4h 55m
- Frequency
- Once daily
- Estimated price
- $35–55
- Website
- Greyhound
Bus from Myrtle Beach Bus Station to Charleston Bus Station
- Ave. Duration
- 2h 25m
- Frequency
- Twice daily
- Estimated price
- $17–26
- Website
- Greyhound
Bus from Myrtle Beach Bus Station to Fayetteville Bus Station
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $27–40
- Website
- Greyhound
Bus from Jacksonville to Sebastian
- Ave. Duration
- 4h 55m
- Frequency
- Once daily
- Estimated price
- $35–55
- Website
- Greyhound
- Phone
- +1 772-343-0217
- Website
- Smart Shuttle Line, Inc.
Shuttle from Orlando Airport to Sebastian, FL - BP
- Ave. Duration
- 1h 22m
- Frequency
- 4 times a day
- Estimated price
- $60–75
- Schedules at
- Smart Shuttle Line, Inc.
- one passenger
- $60–75
Shuttle from Orlando Airport to Sebastian, FL - BP
- Ave. Duration
- 1h 22m
- Frequency
- 4 times a day
- Estimated price
- $60–75
- Schedules at
- Smart Shuttle Line, Inc.
- one passenger
- $60–75
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Fayetteville Bus Station to Jacksonville
- Ave. Duration
- 7h 15m
- Frequency
- Once daily
- Estimated price
- $60–95
- Schedules at
- Flixbus USA
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide
Booking & Getting There
Book your Myrtle Beach to Sebastian bus tickets online with Omio.
There are 138+ hotels available in Sebastian.






