There are 4 ways to get from Myrtle Beach to Lexington by plane, car, bus, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly, drive
best- Fly from Myrtle Beach (MYR) to Louisville International Airport (SDF)plane MYR - SDF
- Drive from Louisville-Airport-SDF to Lexingtoncar
3h 13m$174–483Drive 542.9 mi
cheapest- Drive from Myrtle Beach to Lexingtoncar 542.9 mi
10h 53m$100–144Bus, drive
- Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Nashville Bus Stationbus
- Take the bus from Nashville Bus Station to Evansville Bus Stationbus
- Take the bus from Evansville, IN to Corydon, INbus
- Drive from Middletown Station @ Target to Lexingtoncar
24h 58m$217–345Bus, taxi, drive
- Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Bloomingtonbus
- Take the bus from Bloomington, IN to Paoli Walmartbus
- Take the taxi from Paoli Walmart to Indiana University Southeasttaxi
- Drive from Middletown Station @ Target to Lexingtoncar
28h 14m$247–391
Myrtle Beach (MYR) to Louisville International Airport (SDF) flights
Questions & Answers
The cheapest way to get from Myrtle Beach to Lexington is to drive which costs $95 - $150 and takes 10h 53m.
The fastest way to get from Myrtle Beach to Lexington is to fly and drive which takes 3h 13m and costs $170 - $490.
The distance between Myrtle Beach and Lexington is 578 miles. The road distance is 546 miles.
It takes approximately 3h 13m to get from Myrtle Beach to Lexington, including transfers.
Yes, the driving distance between Myrtle Beach to Lexington is 546 miles. It takes approximately 10h 53m to drive from Myrtle Beach to Lexington.
There are 138+ hotels available in Lexington.
What companies run services between Myrtle Beach, SC, USA and Lexington, KY, USA?
There is no direct connection from Myrtle Beach to Lexington. However, you can take the taxi to Myrtle Beach (MYR) airport, fly to Louisville International Airport (SDF), then drive to Lexington. Alternatively, you can take a bus from Myrtle Beach Bus Station to Lexington via Atlanta Bus Station, Nashville Bus Station, Evansville, IN, Corydon, IN, S 5th @ W Jefferson, and Middletown Station @ Target in around 24h 58m.
- Website
- aa.com
Flights from Myrtle Beach to Louisville International Airport via Charlotte
- Ave. Duration
- 3h 54m
- When
- Every day
- Estimated price
- $80–490
- Website
- delta.com
Flights from Myrtle Beach to Louisville International Airport via Atlanta
- Ave. Duration
- 3h 57m
- When
- Monday to Friday
- Estimated price
- $90–550
- Website
- allegiantair.com
Flights from Myrtle Beach to Louisville International Airport
- Ave. Duration
- 1h 37m
- When
- Saturday
- Estimated price
- $80–490
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Myrtle Beach Bus Station to Atlanta Bus Station
- Ave. Duration
- 8h 55m
- Frequency
- Once daily
- Estimated price
- $50–100
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Nashville Bus Station
- Ave. Duration
- 4h 45m
- Frequency
- Every 4 hours
- Estimated price
- $35–55
- Website
- https://www.greyhound.com/
Bus from Nashville Bus Station to Evansville Bus Station
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $29–45
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Atlanta Bus Station to Nashville Bus Station
- Ave. Duration
- 4h 20m
- Frequency
- 3 times a day
- Estimated price
- $35–55
- Schedules at
- flixbus.com
Bus from Atlanta Bus Station to Bloomington
- Ave. Duration
- 10h 25m
- Frequency
- Once daily
- Estimated price
- $55–100
- Schedules at
- flixbus.com
- Adult
- $55–100
- Phone
- +1 502-368-5644 x 135
- Website
- ridewithmiller.com
Bus from Evansville, IN to Corydon, IN
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $30–45
- Website
- https://ridewithmiller.com
Bus from Bloomington, IN to Paoli Walmart
- Ave. Duration
- 1h 15m
- Frequency
- Once daily
- Estimated price
- $18–28
- Website
- https://ridewithmiller.com
- Ave. Duration
- 1h 1m
- Estimated price
- $110–140
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide






