There are 5 ways to get from Myrtle Beach to Lexington by plane, car, bus (Greyhound), or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Louisville International Airport, drive
best- Fly from Myrtle Beach (MYR) to Louisville International Airport (SDF)plane MYR - SDF
- Drive from Louisville-Airport-SDF to Lexingtoncar
3h 13m$164–483Fly to Blue Grass Airport, line 3 bus
cheapest- Fly from Myrtle Beach (MYR) to Blue Grass Airport (LEX)plane MYR - LEX
- Take the bus from Transit Center to Centre Parkway @ 1349bus
3h 57m$67–344Bus (Greyhound)
- Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus Greyhound US0641
- Take the bus from Atlanta Bus Station to Lexington Bus Stopbus Greyhound US0110
17h 47m$119–211Drive 542.9 mi
- Drive from Myrtle Beach to Lexingtoncar 542.9 mi
10h 53m$100–144Bus via Columbia
- Take the bus from Myrtle Beach, SC to Columbiabus
- Take the bus from Columbia to Atlantabus
- Take the bus from Atlanta Bus Station to Lexington Bus Stopbus
18h 58m$169–337
Myrtle Beach (MYR) to Louisville International Airport (SDF) flights
Questions & Answers
The cheapest way to get from Myrtle Beach to Lexington is to drive which costs $95 - $150 and takes 10h 53m.
The fastest way to get from Myrtle Beach to Lexington is to fly and drive which takes 3h 13m and costs $160 - $490.
The distance between Myrtle Beach and Lexington is 578 miles. The road distance is 546 miles.
The best way to get from Myrtle Beach to Lexington without a car is to bus which takes 17h 47m and costs $110 - $220.
It takes approximately 3h 13m to get from Myrtle Beach to Lexington, including transfers.
Yes, the driving distance between Myrtle Beach to Lexington is 546 miles. It takes approximately 10h 53m to drive from Myrtle Beach to Lexington.
There are 119+ hotels available in Lexington.
What companies run services between Myrtle Beach, SC, USA and Lexington, KY, USA?
You can take a bus from Myrtle Beach Bus Station to Lexington via Atlanta Bus Station and Lexington Bus Stop in around 17h 47m.
- Website
- delta.com
Flights from Myrtle Beach to Louisville International Airport via Atlanta
- Ave. Duration
- 4h 5m
- When
- Every day
- Estimated price
- $90–550
Flights from Myrtle Beach to Blue Grass Airport via Atlanta
- Ave. Duration
- 3h 35m
- When
- Every day
- Estimated price
- $65–370
- Website
- allegiantair.com
Flights from Myrtle Beach to Louisville International Airport
- Ave. Duration
- 1h 37m
- When
- Saturday
- Estimated price
- $80–480
Flights from Myrtle Beach to Blue Grass Airport
- Ave. Duration
- 1h 26m
- When
- Thursday
- Estimated price
- $55–330
- Website
- aa.com
Flights from Myrtle Beach to Louisville International Airport via Charlotte
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- $80–480
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Myrtle Beach Bus Station to Atlanta Bus Station
- Ave. Duration
- 8h 55m
- Frequency
- Once daily
- Estimated price
- $40–70
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Lexington Bus Stop
- Ave. Duration
- 7h 40m
- Frequency
- Once daily
- Estimated price
- $50–110
- Website
- https://www.greyhound.com/
- Phone
- +1 859-253-4636
- info@lextran.com
- Website
- lextran.com
Bus from Transit Center to Centre Parkway @ 1349
- Ave. Duration
- 25 min
- Frequency
- Hourly
- Estimated price
- $1
- Website
- https://lextran.com/
- Seniors 62+
- $1
- Youth 7-18
- $1
- Adult 19+
- $1
- Phone
- +1 404-591-2750
- info@southeasternstages.com
- Website
- southeasternstages.com
Bus from Myrtle Beach, SC to Columbia
- Ave. Duration
- 3h 45m
- Frequency
- Once daily
- Estimated price
- $45–100
- Schedules at
- southeasternstages.com
Bus from Columbia to Atlanta
- Ave. Duration
- 4h 31m
- Frequency
- 4 times a day
- Estimated price
- $60–110
- Schedules at
- southeasternstages.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide




