There are 6 ways to get from Myrtle Beach to Lexington by plane, car, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Covington, drive
best- Fly from Myrtle Beach (MYR) to Covington (CVG)plane MYR - CVG
- Drive from Covington (CVG) to Lexingtoncar
3h 10m$122–636Fly to Blue Grass Airport
cheapest- Fly from Myrtle Beach (MYR) to Blue Grass Airport (LEX)plane MYR - LEX
6h 4m$69–356Bus, drive via Atlanta
- Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Louisville Bus Stationbus
- Drive from Middletown Station @ Target to Lexingtoncar
22h 43m$133–226Drive 542.9 mi
- Drive from Myrtle Beach to Lexingtoncar 542.9 mi
10h 53m$100–144Fly to Louisville International Airport, drive
- Fly from Myrtle Beach (MYR) to Louisville International Airport (SDF)plane MYR - SDF
- Drive from Louisville-Airport-SDF to Lexingtoncar
5h 11m$126–635Bus, drive
- Take the bus from Myrtle Beach Bus Station to Fayetteville Bus Stationbus
- Take the bus from Fayetteville to Winston-Salembus
- Take the bus from Winston Salem to Columbusbus
- Take the bus from Columbus to Louisvillebus
- Drive from Middletown Station @ Target to Lexingtoncar
26h 48m$123–247
Myrtle Beach (MYR) to Covington (CVG) flights
Comparing Your Travel Options
The cheapest way to get from Myrtle Beach to Lexington is to drive which costs $95 - $150 and takes 10h 53m.
The fastest way to get from Myrtle Beach to Lexington is to fly and drive which takes 3h 10m and costs $120 - $650.
The distance between Myrtle Beach and Lexington is 578 miles. The road distance is 546.1 miles.
It takes approximately 3h 10m to get from Myrtle Beach to Lexington, including transfers.
Yes, the driving distance between Myrtle Beach to Lexington is 546 miles. It takes approximately 10h 53m to drive from Myrtle Beach to Lexington.
There are 181+ hotels available in Lexington.
What companies run services between Myrtle Beach, SC, USA and Lexington, KY, USA?
American Airlines, Delta, and United Airlines fly from Myrtle Beach (MYR) to Blue Grass Airport (LEX) every 2 hours.
- Website
- aa.com
Flights from Myrtle Beach to Covington via Charlotte
- Ave. Duration
- 3h 52m
- When
- Every day
- Estimated price
- $95–600
Flights from Myrtle Beach to Louisville International Airport via Charlotte
- Ave. Duration
- 5h 7m
- When
- Every day
- Estimated price
- $100–600
Flights from Myrtle Beach to Blue Grass Airport via Charlotte
- Ave. Duration
- 4h 17m
- When
- Every day
- Estimated price
- $55–340
Flights from Myrtle Beach to Blue Grass Airport via Philadelphia
- Ave. Duration
- 6h 35m
- When
- Every day
- Estimated price
- $85–450
Flights from Myrtle Beach to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 6h 21m
- When
- Every day
- Estimated price
- $90–460
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Myrtle Beach Bus Station to Atlanta Bus Station
- Ave. Duration
- 8h 55m
- Frequency
- Once daily
- Estimated price
- $55–95
- Website
- Greyhound
Bus from Atlanta Bus Station to Louisville Bus Station
- Ave. Duration
- 9h 10m
- Frequency
- Every 4 hours
- Estimated price
- $65–110
- Website
- Greyhound
Bus from Myrtle Beach Bus Station to Fayetteville Bus Station
- Ave. Duration
- 3h
- Frequency
- Once daily
- Estimated price
- $24–40
- Website
- Greyhound
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