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How to get fromMyrtle Beach to Key Largoby plane, shuttle, bus, train, bus (Greyhound, Flixbus), or car

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There are 6 ways to get from Myrtle Beach to Key Largo by plane, shuttle, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Myrtle Beach to Fort Lauderdale–Hollywood International Airport, shuttle

    best
    1. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FLshuttle bus
    4h 48m
    $272–584

  2. Bus

    cheapest
    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Fayetteville Bus Stationbus bus
    3. Take the bus from Fayetteville Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Key Largo Bus Stopbus bus
    23h 40m
    $135–251

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Miami Amtrak Stationtrain train
    3. Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus bus 301
    21h 10m
    $193–435

  4. Drive 737.2 mi

    1. Drive from Myrtle Beach to Key Largocar car 737.2 mi
    13h 5m
    $135–195

  5. Fly Myrtle Beach to Miami International Airport, shuttle

    1. Fly from Myrtle Beach (MYR) to Miami International Airport (MIA)plane plane MYR - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    6h 30m
    $187–524

  6. Bus to Wilmington International Airport, fly to Miami International Airport, shuttle

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Miami International Airport (MIA)plane plane ILM - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Key Largo, FLshuttle bus
    6h 58m
    $190–538

Myrtle Beach to Key Largo by bus, train, and foot

Calendar7Weekly Services
Duration21h 10mAverage Duration
Ticket$193Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Key Largo.ExpandLaunch map view
  • Distance: 617.1 mi
  • Duration: 4h 48m

What companies run services between Myrtle Beach, SC, USA and Key Largo, FL, USA?

You can take a bus from Myrtle Beach Bus Station to Key Largo Bus Stop via Wilmington Cape Fear Public Transit, Fayetteville Bus Station, and Miami Airport Station in around 23h 40m.

Airlines
Train operators
Bus operators

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