There are 5 ways to get from Myrtle Beach to Key Largo by plane, shuttle, bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Myrtle Beach to Fort Lauderdale–Hollywood International Airport, shuttle
best- Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane MYR - FLL
- Take a shuttle bus from Fort Lauderdale, FL - International Airport to Key Largo, FL
4h 41m$175–372Bus, train
cheapest- Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus
- Take the train from Charleston Amtrak Station to Miami Amtrak Stationtrain
- Take the bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largobus 301
21h 9m$111–203Drive 737.2 mi
- Drive from Myrtle Beach to Key Largocar 737.2 mi
13h 4m$135–195Fly Myrtle Beach to Miami International Airport, shuttle
- Fly from Myrtle Beach (MYR) to Miami International Airport (MIA)plane MYR - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
6h 43m$300–552Bus to Wilmington International Airport, fly to Miami International Airport, shuttle
- Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus
- Fly from Wilmington International Airport (ILM) to Miami International Airport (MIA)plane ILM - MIA
- Take a shuttle bus from Miami, FL - International Airport to Key Largo, FL
7h 1m$309–649
Myrtle Beach to Key Largo by bus, train, and foot
Questions & Answers
The cheapest way to get from Myrtle Beach to Key Largo is to bus and train which costs $110 - $210 and takes 21h 9m.
The fastest way to get from Myrtle Beach to Key Largo is to fly and shuttle which takes 4h 41m and costs $170 - $380.
The distance between Myrtle Beach and Key Largo is 621 miles. The road distance is 741.5 miles.
The best way to get from Myrtle Beach to Key Largo without a car is to bus and train which takes 21h 9m and costs $110 - $210.
It takes approximately 4h 41m to get from Myrtle Beach to Key Largo, including transfers.
Yes, the driving distance between Myrtle Beach to Key Largo is 742 miles. It takes approximately 13h 4m to drive from Myrtle Beach to Key Largo.
There are 314+ hotels available in Key Largo.
What companies run services between Myrtle Beach, SC, USA and Key Largo, FL, USA?
There is no direct connection from Myrtle Beach to Key Largo. However, you can take the taxi to Myrtle Beach (MYR) airport, fly to Fort Lauderdale–Hollywood International Airport (FLL), walk to Fort Lauderdale, FL - International Airport, then take the shuttle to Key Largo, FL. Alternatively, you can take a bus from Myrtle Beach Bus Station to Mile Marker 98 Key Largo via Charleston Bus Station, Charleston Amtrak Station, Miami Station, Tri-Rail Station Rail Southbound, Dadeland South Stat.Rail Southbound, Dadeland South Metrorail Station, SW 344 St @ Park & Ride, and W Palm Dr @ 3 Ave in around 21h 9m.
- Website
- aa.com
Flights from Myrtle Beach to Fort Lauderdale–Hollywood International Airport via Charlotte
- Ave. Duration
- 4h 27m
- When
- Every day
- Estimated price
- $50–290
Flights from Myrtle Beach to Miami International Airport via Charlotte
- Ave. Duration
- 5h
- When
- Every day
- Estimated price
- $65–370
Flights from Wilmington International Airport to Miami International Airport
- Ave. Duration
- 2h 8m
- When
- Every day
- Estimated price
- $55–350
Flights from Wilmington International Airport to Miami International Airport via Charlotte
- Ave. Duration
- 4h 33m
- When
- Every day
- Estimated price
- $70–390
- Website
- delta.com
Flights from Myrtle Beach to Fort Lauderdale–Hollywood International Airport via Atlanta
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- $55–300
Flights from Myrtle Beach to Miami International Airport via Atlanta
- Ave. Duration
- 5h 31m
- When
- Every day
- Estimated price
- $70–390
Flights from Wilmington International Airport to Miami International Airport via Atlanta
- Ave. Duration
- 4h 36m
- When
- Every day
- Estimated price
- $80–410
- Website
- southwest.com
Flights from Myrtle Beach to Miami International Airport via Baltimore
- Ave. Duration
- 7h 47m
- When
- Thursday and Saturday
- Estimated price
- $95–460
Flights from Myrtle Beach to Miami International Airport via Nashville
- Ave. Duration
- 9h
- When
- Tuesday and Wednesday
- Estimated price
- $90–450
- Website
- spirit.com
Flights from Myrtle Beach to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 51m
- When
- Every day
- Estimated price
- $45–230
Flights from Myrtle Beach to Fort Lauderdale–Hollywood International Airport via Orlando
- Ave. Duration
- 4h 6m
- When
- Tuesday, Thursday, Saturday, and Sunday
- Estimated price
- $45–230
- Website
- flybreeze.com
Flights from Myrtle Beach to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 50m
- When
- Monday, Wednesday, Friday, and Saturday
- Estimated price
- $90–600
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Charleston Amtrak Station to Miami Amtrak Station
- Ave. Duration
- 14h 3m
- Frequency
- Once daily
- Estimated price
- $90–180
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (305) 289-9997
- groups@keysshuttle.com
- Website
- keysshuttle.com
Shuttle from Fort Lauderdale, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 45m
- Frequency
- 3 times a day
- Estimated price
- $120–150
- Website
- https://www.keysshuttle.com
Shuttle from Miami, FL - International Airport to Key Largo, FL
- Ave. Duration
- 1h 15m
- Frequency
- 3 times a day
- Estimated price
- $100–130
- Website
- https://www.keysshuttle.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Myrtle Beach Bus Station to Charleston Bus Station
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $12–14
- Website
- https://www.greyhound.com/
Bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transit
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $14–21
- Website
- https://www.greyhound.com/
- Phone
- +1 786-469-5675
- Website
- miamidade.gov
Bus from W Palm Dr @ 3 Ave to Mile Marker 98 Key Largo
- Ave. Duration
- 55 min
- Frequency
- Hourly
- Estimated price
- $3
- Website
- https://www.miamidade.gov/global/transportation/home.page
- Adult
- $3
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