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How to get fromMyrtle Beach to Iowaby plane, bus (Greyhound, Flixbus, Amtrak), bus, train, car, or bus (Greyhound, Flixbus)

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There are 9 ways to get from Myrtle Beach to Iowa by plane, bus (Greyhound, Flixbus, Amtrak), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Des Moines

    best
    1. Fly from Myrtle Beach (MYR) to Des Moines (DSM)plane plane MYR - DSM
    4h 50m
    $169–735

  2. Fly to Quad City International Airport

    cheapest
    1. Fly from Myrtle Beach (MYR) to Quad City International Airport (MLI)plane plane MYR - MLI
    6h 4m
    $89–396

  3. Bus via Carbondale

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the bus from Carbondale to St. Louisbus bus
    4. Take the bus from St Louis Bus Station to Des Moinesbus bus
    30h 46m
    $203–405

  4. Bus, train via Galesburg

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Amtrak Station to Wilsonbus bus
    3. Take the train from Wilson to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    5. Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain train
    6. Take the bus from Galesburg to Des Moinesbus bus
    40h 43m
    $470–948

  5. Drive 1,183.8 mi

    1. Drive from Myrtle Beach to Des Moinescar car 1,183.8 mi
    21h 19m
    $216–313

  6. Fly to Omaha

    1. Fly from Myrtle Beach (MYR) to Omaha (OMA)plane plane MYR - OMA
    4h 42m
    $147–594

  7. Fly to The Eastern Iowa Airport

    1. Fly from Myrtle Beach (MYR) to The Eastern Iowa Airport (CID)plane plane MYR - CID
    6h 36m
    $132–454

  8. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Des Moinesbus bus
    31h 5m
    $209–405

  9. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    44h
    $480–942

Myrtle Beach (MYR) to Des Moines (DSM) flights

Calendar63Weekly Planes
Duration5h 48mAverage Duration
Ticket$139Cheapest Price
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Questions & Answers

Map of how to get from Myrtle Beach to Iowa.ExpandLaunch map view
  • Distance: 978.7 mi
  • Duration: 4h 50m

What companies run services between Myrtle Beach, SC, USA and Iowa, USA?

Delta, Southwest Airlines, and two other airlines fly from Myrtle Beach (MYR) to Des Moines (DSM) every 3 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Des Moines via Atlanta Bus Station, Carbondale, St. Louis, St Louis Bus Station, and Des Moines in around 30h 46m.

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