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How to get fromMyrtle Beach to Hyannisby plane, bus, train, bus (Greyhound), car or bus (Greyhound, Flixbus)

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There are 7 ways to get from Myrtle Beach to Hyannis by plane, bus, train, bus (Greyhound), car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Barnstable Municipal Airport

    best
    1. Fly from Myrtle Beach (MYR) to Barnstable Municipal Airport (HYA)plane plane MYR - HYA
    4h 11m
    $85–432

  2. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Bostontrain train
    4. Take the bus from Boston South Station to Hyannis Transportation Centerbus bus
    24h 12m
    $171–1,204

  3. Bus via Chesapeake

    1. Take the bus from Myrtle Beach Bus Station to Norfolkbus bus
    2. Take the bus from Norfolk, VA - Best Square to Times Square – 37th St.bus bus
    3. Take the bus from Port Authority Bus Terminal to Peter Pan Bus Terminalbus bus
    4. Take the bus from Providence Bus Terminal to Hyannis Transportation Centerbus bus
    24h 43m
    $136–253

  4. Drive 882.2 mi

    1. Drive from Myrtle Beach to Hyanniscar car 882.2 mi
    16h 45m
    $161–233

  5. Fly to Boston Logan Airport, bus

    1. Fly from Myrtle Beach (MYR) to Boston Logan Airport (BOS)plane plane MYR - BOS
    2. Take the bus from Logan International Airport to Hyannis Transportation Centerbus bus
    5h 2m
    $108–342

  6. Bus

    1. Take the bus from Myrtle Beach Bus Station to Camdenbus bus
    2. Take the bus from Camden to New York, NYbus bus
    3. Take the bus from New York City Chinatown to Bostonbus bus
    4. Take the bus from Boston South Station to Hyannis Transportation Centerbus bus
    25h 50m
    $162–447

  7. Bus, train via Chesapeake

    1. Take the bus from Myrtle Beach Bus Station to Norfolkbus bus
    2. Take the train from Norfolk to Bostontrain train
    3. Take the bus from Boston South Buses to Hyannis Transportation Centerbus bus
    26h 6m
    $171–687

Myrtle Beach to Hyannis by bus and train

Calendar7Weekly Services
Duration24h 12mAverage Duration
Ticket$171Cheapest Price
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Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Hyannis, MA, USA?

American Airlines, Delta, and Cape Air fly from Myrtle Beach (MYR) to Barnstable Municipal Airport (HYA) twice daily. Alternatively, you can take a bus from Myrtle Beach Bus Station to Hyannis Transportation Center via Norfolk, VA - Best Square, Times Square – 37th St., Port Authority Bus Terminal, and Providence Bus Terminal in around 24h 43m.

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