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How to get fromMyrtle Beach to Des Moinesby plane, bus (Greyhound, Flixbus), bus, train or car

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There are 5 ways to get from Myrtle Beach to Des Moines by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Myrtle Beach (MYR) to Des Moines (DSM)plane plane MYR - DSM
    4h 55m
    $107–443

  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Des Moinesbus bus
    31h 54m
    $166–312

  3. Bus, train via Raleigh

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Cape Fear Public Transit to Raleigh Bus Stationbus bus
    3. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    4. Take the bus from Chicago Bus Station to Des Moinesbus bus
    39h 26m
    $220–419

  4. Drive 1,183.2 mi

    1. Drive from Myrtle Beach to Des Moinescar car 1,183.2 mi
    21h 20m
    $216–312

  5. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    4. Take the bus from Chicago Bus Station to Iowa Citybus bus
    5. Take the bus from Iowa City to Des Moinesbus bus
    41h 4m
    $265–622

Myrtle Beach to Des Moines by bus

Calendar7Weekly Buses
Duration31h 54mAverage Duration
Ticket$166Cheapest Price
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Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Des Moines, IA, USA?

American Airlines, Delta, and United Airlines fly from Myrtle Beach (MYR) to Des Moines (DSM) every 4 hours. Alternatively, you can take a bus from Myrtle Beach Bus Station to Des Moines via Atlanta Bus Station and Chicago Bus Station in around 31h 54m.

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