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How to get fromMyrtle Beach to Chicagoby plane, bus (Greyhound, Flixbus), bus, train or car

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There are 6 ways to get from Myrtle Beach to Chicago by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago Midway International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)planeMYR - MDW
    2h 58m
    $82–407

  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus StationbusGreyhound US0641
    2. Take the bus from Atlanta Bus Station to Chicago Bus StationbusFlixBus 2512 / ...
    24h 20m
    $127–336

  3. Bus, train

    1. Take the bus from Myrtle Beach, SC to Florencebus
    2. Take the bus from Florence Bus Station to Fayetteville Bus Stationbus
    3. Take the train from Fayetteville Amtrak Station to Petersburg Amtrak Stationtrain
    4. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain
    30h 43m
    $299–1,539

  4. Drive 894.8 mi

    1. Drive from Myrtle Beach to Chicagocar894.8 mi
    16h 21m
    $164–236

  5. Fly to Chicago O'Hare International Airport

    1. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)planeMYR - ORD
    3h 19m
    $97–337

  6. Bus via Hurricane

    1. Take the bus from Myrtle Beach, SC to Charlotte Bus Stationbus
    2. Take the bus from Charlotte Bus Station to Hurricanebus
    3. Take the bus from Hurricane to Columbus - Mound Stbus
    4. Take the bus from Columbus - Mound St to Chicagobus
    27h 25m
    $139–313

Myrtle Beach to Chicago by bus

Calendar7Weekly Buses
Duration24h 20mAverage Duration
Ticket$127Cheapest Price
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Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Chicago, IL, USA?

Southwest Airlines flies from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW) twice daily. Alternatively, you can take a bus from Myrtle Beach Bus Station to Chicago Bus Station via Atlanta Bus Station in around 24h 20m.

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