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How to get fromMyrtle Beach to Chicagoby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 6 ways to get from Myrtle Beach to Chicago by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago Midway International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    2h 53m
    $89–439

  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus Greyhound US0641
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    25h 55m
    $155–345

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    31h 57m
    $366–811

  4. Drive 896.3 mi

    1. Drive from Myrtle Beach to Chicagocar car 896.3 mi
    16h 29m
    $164–237

  5. Fly to Chicago O'Hare International Airport

    1. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    3h 26m
    $204–569

  6. Bus, train via Raleigh

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus Greyhound US0645S
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train Floridian
    36h 5m
    $372–787

Myrtle Beach to Chicago by bus

Calendar7Weekly Buses
Duration25h 55mAverage Duration
Ticket$155Cheapest Price
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Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Chicago, IL, USA?

Southwest Airlines flies from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW) twice daily. Alternatively, you can take a bus from Myrtle Beach Bus Station to Chicago Bus Station via Atlanta Bus Station in around 25h 55m.

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