Rome2Rio

How to get fromMyrtle Beach to Chicagoby plane, bus (Greyhound, Flixbus), bus, train or car

Find Transport to Chicago

See all options

There are 6 ways to get from Myrtle Beach to Chicago by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago Midway International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    2h 58m
    $92–457

  2. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus Greyhound US0641
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus FlixBus 2512 / ...
    24h 20m
    $130–269

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    32h 31m
    $212–533

  4. Drive 894.8 mi

    1. Drive from Myrtle Beach to Chicagocar car 894.8 mi
    16h 32m
    $164–236

  5. Fly to Chicago O'Hare International Airport

    1. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    3h 19m
    $107–287

  6. Bus, train via Raleigh

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Amtrak Station to Wilsonbus bus
    3. Take the train from Wilson to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    34h 35m

Myrtle Beach to Chicago by bus

Calendar7Weekly Buses
Duration24h 20mAverage Duration
Ticket$130Cheapest Price
See schedules

Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Chicago, IL, USA?

Southwest Airlines flies from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW) once daily. Alternatively, you can take a bus from Myrtle Beach Bus Station to Chicago Bus Station via Atlanta Bus Station in around 24h 20m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers

Where to next?

Trips from Myrtle Beach

Trips to Chicago

Popular routes