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How to get fromMyrtle Beach, SC to Chicagoby plane, bus (Greyhound, Flixbus), bus, train or car

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There are 7 ways to get from Myrtle Beach, SC to Chicago by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Myrtle Beach to Chicago O'Hare International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    3h 19m
    $108–288

  2. Fly Myrtle Beach to Chicago Midway International Airport

    cheapest
    1. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    2h 58m
    $98–508

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus Greyhound US0641
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus FlixBus 2512 / ...
    24h 20m
    $145–330

  4. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    32h 31m
    $296–690

  5. Drive 894.6 mi

    1. Drive from Myrtle Beach, SC to Chicagocar car 894.6 mi
    16h 32m
    $164–236

  6. Bus to Wilmington International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Chicago O'Hare International Airport (ORD)plane plane ILM - ORD
    6h 6m
    $169–466

  7. Bus, train via Raleigh

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Take the bus from Wilmington Amtrak Station to Wilsonbus bus
    3. Take the train from Wilson to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    34h 35m
    $305–671

Myrtle Beach, SC to Chicago by bus

Calendar7Weekly Buses
Duration24h 20mAverage Duration
Ticket$145Cheapest Price
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Questions & Answers

What companies run services between Myrtle Beach, SC, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Southwest Airlines fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD) twice daily. Alternatively, you can take a bus from Myrtle Beach Bus Station to Chicago Bus Station via Atlanta Bus Station in around 24h 20m.

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