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How to get fromMurrells Inlet to Port Saint Lucieby plane, bus, train, bus (Greyhound, Flixbus) or car

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There are 6 ways to get from Murrells Inlet to Port Saint Lucie by plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Orlando, bus

    best
    1. Fly from Myrtle Beach (MYR) to Orlando (MCO)plane plane MYR - MCO
    2. Take the bus from Orlando - RedCoach Station, FL to Fort Piercebus bus
    5h 2m
    $146–472

  2. Drive 551.6 mi

    cheapest
    1. Drive from Murrells Inlet to Port Saint Luciecar car 551.6 mi
    9h 49m
    $101–146

  3. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Winter Park Amtrak Stationtrain train
    3. Take the bus from Orlando - RedCoach Station, FL to Fort Piercebus bus
    15h 42m
    $142–393

  4. Bus

    1. Take the bus from Myrtle Beach, SC to Florencebus bus
    2. Take the bus from Florence Bus Station to Orlando Bus Stationbus bus
    3. Take the bus from Orlando Bus Station to Port St Luciebus bus
    16h 35m
    $153–438

  5. Fly to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane MYR - FLL
    2. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    5h 54m
    $116–355

  6. Bus, train via Oak Ridge

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Orlandotrain train
    3. Take the bus from Universal Boulevard And Hollywood Way to Fort Piercebus bus
    16h 42m
    $163–260

Myrtle Beach (MYR) to Orlando (MCO) flights

Calendar31Weekly Planes
Duration3h 15mAverage Duration
Ticket$56Cheapest Price
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Questions & Answers

What companies run services between Murrells Inlet, SC, USA and Port Saint Lucie, FL, USA?

You can take a vehicle from Murrells Inlet to SW PSL Blvd & SE Bayshore Blvd via Myrtle Beach, SC, Florence, Florence Bus Station, Orlando Bus Station, and SW Gatlin Blvd & SW Brescia St in around 16h 35m.

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