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How to get fromMurrells Inlet to Knoxvilleby plane, bus, shuttle, car, or taxi

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There are 4 ways to get from Murrells Inlet to Knoxville by plane, bus, shuttle, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS)plane plane MYR - TYS
    3h 50m
    $191–768

  2. Drive  409.6 mi

    cheapest
    1. Drive from Murrells Inlet to Knoxvillecar car 409.6 mi
    7h 49m
    $75–108

  3. Bus, shuttle, drive

    1. Take the bus from Myrtle Beach Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte to Boonebus bus
    4. Take a shuttle bus from Boone to Black Bear Resortshuttle bus
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Knoxvillecar car
    15h 46m
    $325–366

  4. Bus, taxi, shuttle, drive

    1. Take the bus from Myrtle Beach Bus Station to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Airport to ASU Peacock Hall Boonebus bus
    4. Take the taxi from ASU Peacock Hall Boone to Black Bear Resorttaxi taxi
    5. Take a shuttle bus from Black Bear Resort to Hot Springsshuttle bus
    6. Drive from Hot Springs to Chilhowee at Holstoncar car
    16h 7m
    $436–520

Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS) flights

Calendar64Weekly Planes
Duration4h 27mAverage Duration
Ticket$97Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Murrells Inlet to Knoxville.ExpandLaunch map view
  • Distance: 348.8 mi
  • Duration: 3h 50m

What companies run services between Murrells Inlet, SC, USA and Knoxville, TN, USA?

Delta, American Airlines, and Southwest Airlines fly from Myrtle Beach (MYR) to Mcghee Tyson Airport (TYS) every 3 hours.

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