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How to get fromMurrells Inlet to Key Westby plane, car, train, bus, bus (Greyhound, Flixbus) or shuttle

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There are 6 ways to get from Murrells Inlet to Key West by plane, car, train, bus, bus (Greyhound, Flixbus), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Myrtle Beach

    best
    1. Fly from Myrtle Beach (MYR) to Key West International Airport (EYW)plane plane MYR - EYW
    5h 13m
    $152–611

  2. Drive 821 mi

    cheapest
    1. Drive from Murrells Inlet to Key Westcar car 821 mi
    15h 1m
    $150–217

  3. Drive, train, bus

    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Hollywood Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    24h 3m
    $226–487

  4. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    30h 43m
    $205–435

  5. Bus to Wilmington International Airport, fly

    1. Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Key West International Airport (EYW)plane plane ILM - EYW
    7h 22m
    $175–656

  6. Bus, train, shuttle

    1. Take the bus from Myrtle Beach Bus Station to Charleston Bus Stationbus bus
    2. Take the train from Charleston Amtrak Station to Miami Amtrak Stationtrain train
    3. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    24h 58m
    $402–685

Myrtle Beach (MYR) to Key West International Airport (EYW) flights

Calendar46Weekly Planes
Duration5h 34mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

What companies run services between Murrells Inlet, SC, USA and Key West, FL, USA?

Delta and American Airlines fly from Myrtle Beach (MYR) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a vehicle from Murrells Inlet to N Roosevelt & 3rd Street via Myrtle Beach Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 30h 43m.

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