There are 10 ways to get from Murrells Inlet to Fort Myers by plane, bus (Greyhound, Flixbus), car, train, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Myrtle Beach to Ft. Myers
best- Fly from Myrtle Beach (MYR) to Ft. Myers (RSW)MYR - RSW
6h 17m$285–425Drive, train, bus
cheapest- Drive from Murrells Inlet to Kingstree Station
- Take the train from Kingstree Station to Fort Lauderdale Amtrak Station
- Take the bus from Hollywood Sheridan Trirail Station to Fort Myers Bus Stop
20h 22m$102–282Bus
- Take the bus from Myrtle Beach, SC to Florence
- Take the bus from Florence Bus Station to Orlando Bus Station
- Take the bus from Orlando Bus Station to Fort Myers Bus Stop
17h 41m$170–493Drive 609.7 mi
- Drive from Murrells Inlet to Fort Myers609.7 mi
11h 18m$112–161Fly Myrtle Beach to Tampa, bus
- Fly from Myrtle Beach (MYR) to Tampa (TPA)MYR - TPA
- Take the bus from Tampa International Airport to Fort Myers 7-11
5h 30m$177–448Fly Myrtle Beach to Fort Lauderdale–Hollywood International Airport, bus
- Fly from Myrtle Beach (MYR) to Fort Lauderdale–Hollywood International Airport (FLL)MYR - FLL
- Take the bus from Fort Lauderdale International Airport to Fort Myers Bus Stop
5h 41m$131–365Bus to Wilmington International Airport, fly to Ft. Myers
- Take the bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transit
- Fly from Wilmington International Airport (ILM) to Ft. Myers (RSW)ILM - RSW
7h 2m$174–592Fly Myrtle Beach to Orlando, bus
- Fly from Myrtle Beach (MYR) to Orlando (MCO)MYR - MCO
- Take the bus from Orlando to Fort Myers Bus Stop
9h 12m$154–372Bus, train via Jacksonville
- Take the bus from Myrtle Beach Bus Station to Charleston Bus Station
- Take the train from Charleston Amtrak Station to Jacksonville
- Take the bus from Jacksonville to Wildwood Amtrak Station
- Take the bus from Wildwood to Fort Myers
18h 38mBus, train
- Take the bus from Myrtle Beach Bus Station to Charleston Bus Station
- Take the train from Charleston Amtrak Station to Winter Park Amtrak Station
- Take the bus from Orlando to Fort Myers Bus Stop
19h 36m$163–360
Myrtle Beach (MYR) to Ft. Myers (RSW) flights
Questions & Answers
The cheapest way to get from Murrells Inlet to Fort Myers is to drive which costs $110 - $170 and takes 11h 18m.
The fastest way to get from Murrells Inlet to Fort Myers is to fly and bus which takes 5h 30m and costs $170 - $450.
The distance between Murrells Inlet and Fort Myers is 553 miles. The road distance is 613.2 miles.
The best way to get from Murrells Inlet to Fort Myers without a car is to bus which takes 17h 41m and costs $170 - $500.
It takes approximately 6h 17m to get from Murrells Inlet to Fort Myers, including transfers.
The best way to get from Murrells Inlet to Fort Myers is to fly which takes 6h 17m and costs $280 - $430. Alternatively, you can bus, which costs $170 - $500 and takes 17h 41m.
Yes, the driving distance between Murrells Inlet to Fort Myers is 613 miles. It takes approximately 11h 18m to drive from Murrells Inlet to Fort Myers.
There are 3005+ hotels available in Fort Myers.
What companies run services between Murrells Inlet, SC, USA and Fort Myers, FL, USA?
American Airlines, Delta, and Southwest Airlines fly from Myrtle Beach (MYR) to Ft. Myers (RSW) every 2 hours. Alternatively, you can take a vehicle from Murrells Inlet to Fort Myers Bus Stop via Myrtle Beach, SC, Florence, Florence Bus Station, and Orlando Bus Station in around 17h 41m.
- Website
- delta.com
Flights from Myrtle Beach to Ft. Myers via Atlanta
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $100–500
Flights from Myrtle Beach to Tampa via Atlanta
- Ave. Duration
- 4h 8m
- When
- Every day
- Estimated price
- $65–360
Flights from Myrtle Beach to Fort Lauderdale–Hollywood International Airport via Atlanta
- Ave. Duration
- 4h 24m
- When
- Every day
- Estimated price
- $55–290
Flights from Wilmington International Airport to Ft. Myers via Atlanta
- Ave. Duration
- 4h 36m
- When
- Every day
- Estimated price
- $100–550
Flights from Myrtle Beach to Orlando via Atlanta
- Ave. Duration
- 4h 1m
- When
- Every day
- Estimated price
- $60–330
- Website
- aa.com
Flights from Myrtle Beach to Ft. Myers via Charlotte
- Ave. Duration
- 4h 50m
- When
- Every day
- Estimated price
- $95–490
Flights from Myrtle Beach to Tampa via Charlotte
- Ave. Duration
- 3h 59m
- When
- Every day
- Estimated price
- $65–350
Flights from Myrtle Beach to Fort Lauderdale–Hollywood International Airport via Charlotte
- Ave. Duration
- 4h 26m
- When
- Every day
- Estimated price
- $50–280
Flights from Wilmington International Airport to Ft. Myers via Charlotte
- Ave. Duration
- 4h 15m
- When
- Every day
- Estimated price
- $95–490
Flights from Myrtle Beach to Orlando via Charlotte
- Ave. Duration
- 3h 52m
- When
- Every day
- Estimated price
- $55–320
- Website
- southwest.com
Flights from Myrtle Beach to Ft. Myers via Nashville
- Ave. Duration
- 5h 35m
- When
- Monday, Tuesday, Friday, Saturday, and Sunday
- Estimated price
- $120–600
Flights from Myrtle Beach to Ft. Myers via Baltimore
- Ave. Duration
- 5h 58m
- When
- Wednesday, Thursday, and Saturday
- Estimated price
- $130–650
Flights from Myrtle Beach to Ft. Myers via Columbus
- Ave. Duration
- 5h 10m
- When
- Saturday
- Estimated price
- $140–650
- Website
- flybreeze.com
Flights from Myrtle Beach to Tampa
- Ave. Duration
- 1h 42m
- When
- Monday, Tuesday, Thursday, Friday, and Sunday
- Estimated price
- $140–260
Flights from Myrtle Beach to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 50m
- When
- Monday and Friday
- Estimated price
- $100–480
Flights from Wilmington International Airport to Ft. Myers
- Ave. Duration
- 1h 55m
- When
- Monday and Friday
- Estimated price
- $200–900
Flights from Myrtle Beach to Orlando
- Ave. Duration
- 1h 40m
- When
- Thursday and Sunday
- Estimated price
- $120–600
- Website
- spirit.com
Flights from Myrtle Beach to Fort Lauderdale–Hollywood International Airport
- Ave. Duration
- 1h 52m
- When
- Every day
- Estimated price
- $65–240
Flights from Myrtle Beach to Orlando
- Ave. Duration
- 1h 38m
- When
- Thursday and Sunday
- Estimated price
- $70–240
- Website
- aveloair.com
Flights from Wilmington International Airport to Ft. Myers
- Ave. Duration
- 1h 59m
- When
- Monday and Friday
- Estimated price
- $160–650
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Kingstree Station to Fort Lauderdale Amtrak Station
- Ave. Duration
- 14h 10m
- Frequency
- Once daily
- Estimated price
- $65–220
- Website
- https://www.amtrak.com/home.html
- Coach Seat - Advance Purchase
- $65–170
- Coach Seat short notice purchase
- $90–220
- Business - advance purchase
- $120–500
- Business Class
- $200–490
Train from Charleston Amtrak Station to Jacksonville
- Ave. Duration
- 4h 28m
- Frequency
- Once daily
- Estimated price
- $60–150
- Website
- https://www.amtrak.com/home.html
Train from Charleston Amtrak Station to Winter Park Amtrak Station
- Ave. Duration
- 7h 43m
- Frequency
- Once daily
- Estimated price
- $75–220
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 404-591-2750
- info@southeasternstages.com
- Website
- southeasternstages.com
Bus from Myrtle Beach, SC to Florence
- Ave. Duration
- 1h 30m
- Frequency
- Once daily
- Estimated price
- $25–95
- Schedules at
- southeasternstages.com
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from Myrtle Beach, SC to Florence
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $26–55
- Website
- https://www.greyhound.com/
Bus from Myrtle Beach Bus Station to Wilmington Cape Fear Public Transit
- Ave. Duration
- 1h 40m
- Frequency
- Once daily
- Estimated price
- $17–26
- Website
- https://www.greyhound.com/
Bus from Myrtle Beach Bus Station to Charleston Bus Station
- Ave. Duration
- 2h 25m
- Frequency
- Once daily
- Estimated price
- $11–15
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from Florence Bus Station to Orlando Bus Station
- Ave. Duration
- 8h 55m
- Frequency
- Once daily
- Estimated price
- $70–270
- Schedules at
- flixbus.com
Bus from Orlando Bus Station to Fort Myers Bus Stop
- Ave. Duration
- 4h 55m
- Frequency
- 4 times a day
- Estimated price
- $30–75
- Schedules at
- flixbus.com
Bus from Hollywood Sheridan Trirail Station to Fort Myers Bus Stop
- Ave. Duration
- 2h 55m
- Frequency
- 6 times a week
- Estimated price
- $24–40
- Schedules at
- flixbus.com
Bus from Fort Lauderdale International Airport to Fort Myers Bus Stop
- Ave. Duration
- 2h 25m
- Frequency
- 3 times a day
- Estimated price
- $24–55
- Schedules at
- flixbus.com
Bus from Orlando to Fort Myers Bus Stop
- Ave. Duration
- 5h 35m
- Frequency
- 3 times a day
- Estimated price
- $30–70
- Schedules at
- flixbus.com
- Phone
- +1 877 733 0724
- Website
- redcoachusa.com
Bus from Tampa International Airport to Fort Myers 7-11
- Ave. Duration
- 2h 10m
- Frequency
- 5 times a week
- Estimated price
- $15–65
- Website
- https://www.redcoachusa.com
- Web
- $15–65
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from Jacksonville to Wildwood Amtrak Station
- Ave. Duration
- 3h 55m
- Frequency
- Once daily
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 800-923-1799
- contactus@omexusa.net
- Website
- omnibusexpress.com
Bus from Wildwood to Fort Myers
- Ave. Duration
- 4h 29m
- Frequency
- Once daily
- Estimated price
- $60–80
- Schedules at
- omnibusexpress.com
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide
Why you should take the train in the US
Read the travel guide














