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How to get fromMurrells Inlet to Chicagoby plane, bus (Greyhound, Flixbus), car, train, or bus

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There are 6 ways to get from Murrells Inlet to Chicago by plane, bus (Greyhound, Flixbus), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago Midway International Airport

    best
    1. Fly from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW)plane plane MYR - MDW
    3h 8m
    $108–403

  2. Fly to Chicago O'Hare International Airport

    cheapest
    1. Fly from Myrtle Beach (MYR) to Chicago O'Hare International Airport (ORD)plane plane MYR - ORD
    3h 38m
    $98–353

  3. Bus

    1. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus Greyhound US0641S
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    26h 16m
    $193–371

  4. Drive, train (Amtrak)

    1. Drive from Murrells Inlet to Kingstree Stationcar car
    2. Take the train from Kingstree Station to Petersburg Amtrak Stationtrain train
    3. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train
    29h 46m
    $371–817

  5. Drive 903.9 mi

    1. Drive from Murrells Inlet to Chicagocar car 903.9 mi
    16h 45m
    $165–239

  6. Bus, train

    1. Take the bus from Myrtle Beach Bus Station to Raleigh Bus Stationbus bus Greyhound US0645S
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train Floridian
    36h 37m
    $430–883

Myrtle Beach (MYR) to Chicago Midway International Airport (MDW) flights

Calendar14Weekly Planes
Duration3h 46mAverage Duration
Ticket$67Cheapest Price
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Comparing Your Travel Options

Map of how to get from Murrells Inlet to Chicago.ExpandLaunch map view
  • Distance: 762.1 mi
  • Duration: 3h 8m

What companies run services between Murrells Inlet, SC, USA and Chicago, IL, USA?

Southwest Airlines flies from Myrtle Beach (MYR) to Chicago Midway International Airport (MDW) twice daily. Alternatively, you can take a vehicle from Murrells Inlet to Chicago Bus Station via Myrtle Beach Bus Station and Atlanta Bus Station in around 26h 16m.

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