Rome2Rio

How to get fromMurphysboro to Indianapolisby bus (Amtrak, Flixbus, Greyhound), car, plane or bus (Flixbus)

Find Transport to Indianapolis

See all options

There are 4 ways to get from Murphysboro to Indianapolis by bus (Amtrak, Flixbus, Greyhound), car, plane, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Carbondale to St. Louisbus bus Amtrak Thruway Connecting Service
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    7h 36m
    $70–113

  2. Drive 263.8 mi

    cheapest
    1. Drive from Murphysboro to Indianapoliscar car 263.8 mi
    4h 37m
    $49–70

  3. Fly

    1. Fly from Williamson County Regional Airport (MWA) to Indianapolis (IND)plane plane MWA - IND
    5h 24m
    $171–660

  4. Bus via Nashville (Flixbus)

    1. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus FlixBus N2521
    2. Take the bus from Nashville Bus Station to Indianapolisbus bus FlixBus 2512
    10h 36m
    $89–198

Williamson County Regional Airport (MWA) to Indianapolis (IND) flights

Calendar17Weekly Planes
Duration5h 14mAverage Duration
Ticket$125Cheapest Price
See schedules

Questions & Answers

What companies run services between Murphysboro, IL, USA and Indianapolis, IN, USA?

You can take a vehicle from Murphysboro to Indianapolis Union Station via Carbondale, St. Louis, and St Louis Bus Station in around 7h 36m. Alternatively, Corporate Flight Management Inc, United Airlines, and Delta fly from Williamson County Regional Airport (MWA) to Indianapolis (IND) twice daily.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Where to next?

Trips from Murphysboro

Trips to Indianapolis

Popular routes