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How to get fromMurphysboro to Indianapolisby bus (Amtrak, Flixbus, Greyhound), car, bus, plane or bus (Flixbus)

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There are 5 ways to get from Murphysboro to Indianapolis by bus (Amtrak, Flixbus, Greyhound), car, bus, plane, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Carbondale to St. Louisbus bus Amtrak Thruway Connecting Service
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    7h 36m
    $70–108

  2. Drive 263.8 mi

    cheapest
    1. Drive from Murphysboro to Indianapoliscar car 263.8 mi
    4h 38m
    $49–70

  3. Bus to Lambert–St. Louis International Airport, fly

    1. Take the bus from Carbondale to St. Louisbus bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane plane STL - IND
    8h 10m
    $335–608

  4. Bus via Nashville (Flixbus)

    1. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus FlixBus N2521
    2. Take the bus from Nashville Bus Station to Indianapolisbus bus FlixBus 2512
    10h 36m
    $89–203

  5. Fly from Williamson County Regional Airport

    1. Fly from Williamson County Regional Airport (MWA) to Indianapolis (IND)plane plane MWA - IND
    5h 24m
    $181–610

Lambert–St. Louis International Airport (STL) to Indianapolis (IND) flights

Calendar124Weekly Planes
Duration4h 18mAverage Duration
Ticket$92Cheapest Price
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Questions & Answers

What companies run services between Murphysboro, IL, USA and Indianapolis, IN, USA?

You can take a vehicle from Murphysboro to Indianapolis Union Station via Carbondale, St. Louis, and St Louis Bus Station in around 7h 36m. Alternatively, Corporate Flight Management Inc and United Airlines fly from Williamson County Regional Airport (MWA) to Indianapolis (IND) 6 times a week.

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Need to know: Greyhound

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