There are 9 ways to get from Missouri to Chicago by plane, train (Amtrak), bus (Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Columbia Regional Airport to Chicago O'Hare International Airport
best- Fly from Columbia Regional Airport (COU) to Chicago O'Hare International Airport (ORD)plane COU - ORD
2h 37m$97–321Fly Lambert–St. Louis International Airport to Chicago Midway International Airport
cheapest- Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane STL - MDW
3h 17m$60–378Train (Amtrak)
- Take the train from Kansas City to Chicago Union Stationtrain Southwest Chief / ...
8h 47m$130–290Bus (Greyhound)
- Take the bus from Kansas City Bus Station to Des Moinesbus Greyhound US0156
- Take the bus from Des Moines to Chicago Bus Stationbus Greyhound US0123S / ...
11h 15m$79–150Drive 502.7 mi
- Drive from Kansas City to Chicagocar 502.7 mi
8h 43m$92–133Fly Springfield-Branson National Airport to Chicago O'Hare International Airport
- Fly from Springfield-Branson National Airport (SGF) to Chicago O'Hare International Airport (ORD)plane SGF - ORD
2h 45m$63–294Fly Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane STL - ORD
3h 40m$274–708Fly Kansas City to Chicago Midway International Airport
- Fly from Kansas City (MCI) to Chicago Midway International Airport (MDW)plane MCI - MDW
3h 53m$72–435Fly Kansas City to Chicago O'Hare International Airport
- Fly from Kansas City (MCI) to Chicago O'Hare International Airport (ORD)plane MCI - ORD
4h 21m$352–755
Missouri to Chicago by tram and train (Amtrak)
Comparing Your Travel Options
The cheapest way to get from Missouri to Chicago is to bus which costs $75 - $150 and takes 11h 15m.
The fastest way to get from Missouri to Chicago is to fly which takes 2h 37m and costs $95 - $330.
No, there is no direct bus from Missouri station to Chicago station. However, there are services departing from Kansas City Bus Station and arriving at Chicago Bus Station via Des Moines. The journey, including transfers, takes approximately 11h 15m.
No, there is no direct train from Missouri to Chicago station. However, there are services departing from Metro Center and arriving at Chicago Union Station via Kansas City. The journey, including transfers, takes approximately 8h 47m.
The distance between Missouri and Chicago is 348 miles. The road distance is 505.7 miles.
The best way to get from Missouri to Chicago without a car is to train which takes 8h 47m and costs $130 - $290.
It takes approximately 2h 37m to get from Missouri to Chicago, including transfers.
Missouri to Chicago bus services, operated by Greyhound USA, depart from Kansas City Bus Station.
Missouri to Chicago train services, operated by Amtrak, depart from Kansas City station.
The best way to get from Missouri to Chicago is to fly which takes 2h 37m and costs $95 - $330. Alternatively, you can train, which costs $130 - $290 and takes 8h 47m, you could also bus, which costs $75 - $150 and takes 11h 15m.
What companies run services between Missouri, USA and Chicago, IL, USA?
American Airlines and United Airlines fly from Columbia Regional Airport (COU) to Chicago O'Hare International Airport (ORD) every 4 hours. Alternatively, Amtrak operates a train from Kansas City to Chicago Union Station twice daily. Tickets cost $130–290 and the journey takes 7h 41m.
- Website
- southwest.com
Flights from Lambert–St. Louis International Airport to Chicago Midway International Airport
- Ave. Duration
- 1h 5m
- When
- Every day
- Estimated price
- $55–370
Flights from Kansas City to Chicago Midway International Airport
- Ave. Duration
- 1h 23m
- When
- Every day
- Estimated price
- $70–430
Flights from Kansas City to Chicago Midway International Airport via Lambert–St. Louis International Airport
- Ave. Duration
- 3h 20m
- When
- Sunday, Monday, Thursday, Friday, Tuesday, and Wednesday
- Estimated price
- $80–450
Flights from Kansas City to Chicago Midway International Airport via Milwaukee
- Ave. Duration
- 3h 15m
- When
- Saturday
- Estimated price
- $80–460
- Website
- united.com
Flights from Columbia Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 43m
- When
- Every day
- Estimated price
- $40–250
Flights from Springfield-Branson National Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 55m
- When
- Every day
- Estimated price
- $45–270
Flights from Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 33m
- When
- Every day
- Estimated price
- $45–310
Flights from Kansas City to Chicago O'Hare International Airport
- Ave. Duration
- 1h 52m
- When
- Every day
- Estimated price
- $60–370
- Website
- aa.com
Flights from Columbia Regional Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 42m
- When
- Every day
- Estimated price
- $40–250
Flights from Springfield-Branson National Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 54m
- When
- Every day
- Estimated price
- $45–270
Flights from Lambert–St. Louis International Airport to Chicago O'Hare International Airport
- Ave. Duration
- 1h 32m
- When
- Every day
- Estimated price
- $45–310
Flights from Kansas City to Chicago O'Hare International Airport
- Ave. Duration
- 1h 52m
- When
- Every day
- Estimated price
- $60–370
- Website
- delta.com
Flights from Kansas City to Chicago O'Hare International Airport via Minneapolis
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- $85–440
Flights from Kansas City to Chicago O'Hare International Airport via Detroit
- Ave. Duration
- 4h 22m
- When
- Every day
- Estimated price
- $95–470
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Kansas City to Chicago Union Station
- Ave. Duration
- 7h 41m
- Frequency
- Twice daily
- Estimated price
- $130–290
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- Greyhound
Bus from Kansas City Bus Station to Des Moines
- Ave. Duration
- 3h 10m
- Frequency
- Twice daily
- Estimated price
- $29–60
- Website
- Greyhound
Bus from Des Moines to Chicago Bus Station
- Ave. Duration
- 7h 5m
- Frequency
- 5 times a day
- Estimated price
- $50–95
- Website
- Greyhound
Want to know more about travelling around United States
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Booking & Getting There
Missouri to Chicago bus services, operated by Greyhound USA, arrive at Des Moines station.
Missouri to Chicago train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Missouri to Chicago is 506 miles. It takes approximately 8h 43m to drive from Missouri to Chicago.
Book your Missouri to Chicago bus tickets online with FlixBus.
There are 1209+ hotels available in Chicago.