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How to get fromMissouri to Buffaloby plane, bus (Greyhound), train (Amtrak), car, or bus

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There are 7 ways to get from Missouri to Buffalo by plane, bus (Greyhound), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Lambert–St. Louis International Airport to Buffalo Niagara International Airport

    best
    1. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    6h 5m
    $138–780

  2. Fly Lambert–St. Louis International Airport to Toronto Pearson International Airport, bus

    cheapest
    1. Fly from Lambert–St. Louis International Airport (STL) to Toronto Pearson International Airport (YYZ)plane plane STL - YYZ
    2. Take the bus from Toronto Pearson Airport to Buffalobus bus
    8h 41m
    $92–436

  3. Bus

    1. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis to Toledobus bus
    4. Take the bus from Toledo to Clevelandbus bus
    5. Take the bus from Cleveland to Buffalobus bus
    21h 35m
    $141–308

  4. Train (Amtrak)

    1. Take the train from Kansas City to Chicago Union Stationtrain train Southwest Chief / ...
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    21h 51m
    $535–823

  5. Drive  976.7 mi

    1. Drive from Kansas City to Buffalocar car 976.7 mi
    16h 40m
    $167–242

  6. Fly Kansas City to Buffalo Niagara International Airport

    1. Fly from Kansas City (MCI) to Buffalo Niagara International Airport (BUF)plane plane MCI - BUF
    6h 38m
    $185–978

  7. Fly Lambert–St. Louis International Airport to Rochester, bus

    1. Fly from Lambert–St. Louis International Airport (STL) to Rochester (ROC)plane plane STL - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 19m
    $212–1,046

Missouri to Buffalo by bus

Calendar7Weekly Buses
Duration21h 35mAverage Duration
Ticket$141Cheapest Price
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Comparing Your Travel Options

Map of how to get from Missouri to Buffalo.ExpandLaunch map view
  • Distance: 696.4 mi
  • Duration: 6h 5m

What companies run services between Missouri, USA and Buffalo, NY, USA?

Delta, Southwest Airlines, and two other airlines fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF) hourly. Alternatively, you can take a bus from Kansas City Bus Station to Buffalo via St Louis Bus Station, Indianapolis, Toledo, and Cleveland in around 21h 35m.

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Want to know more about travelling around United States

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