There are 8 ways to get from Mississippi to Key West by plane, train, bus, ferry, car, bus (Greyhound, Flixbus), or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Gulfport-Biloxi Regional Airport
best- Fly from Gulfport-Biloxi Regional Airport (GPT) to Key West International Airport (EYW)plane GPT - EYW
5h 59m$141–674Drive to Golden Triangle Regional Airport, fly
cheapest- Drive from Tupelo to Golden Triangle Regional Airport (GTR)car
- Fly from Golden Triangle Regional Airport (GTR) to Key West International Airport (EYW)plane GTR - EYW
5h 13m$122–579Train, bus, ferry
- Take the train from Jackson to New Orleans Union Passenger Terminaltrain
- Take the bus from New Orleans Bus Station to Biloxi Transit Centerbus
- Take the bus from Biloxi to Fort Myersbus
- Take the ferry from Fort Myers Beach, FL to Key West, FLferry
27h 16m$327–419Drive 1,044.3 mi
- Drive from Jackson to Key Westcar 1,044.3 mi
18h 50m$191–276Fly from Memphis
- Fly from Memphis (MEM) to Key West International Airport (EYW)plane MEM - EYW
4h 14m$182–838Fly from Jackson/Vicksburg
- Fly from Jackson/Vicksburg (JAN) to Key West International Airport (EYW)plane JAN - EYW
4h 52m$220–959Bus
- Take the bus from Jackson to Atlanta Bus Stationbus
- Take the bus from Atlanta Bus Station to Miami Airport Stationbus
- Take the bus from Miami Airport Station to Big Pine Keybus
- Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus Lks
29h 31m$131–276Bus, shuttle
- Take the bus from Jackson to Baton Rouge Bus Stationbus
- Take the bus from Baton Rouge Bus Station to Lafayettebus
- Take the bus from Lafayette to Dolphin Mall - Miamibus
- Take a shuttle bus from Bayside Marketplace to Plaza Hotel
36h 16m$280–478
Gulfport-Biloxi Regional Airport (GPT) to Key West International Airport (EYW) flights
Questions & Answers
The cheapest way to get from Mississippi to Key West is to bus which costs $130 - $280 and takes 29h 31m.
The fastest way to get from Mississippi to Key West is to fly which takes 4h 14m and costs $180 - $850.
No, there is no direct bus from Mississippi to Key West. However, there are services departing from Jackson and arriving at N Roosevelt & 3rd Street via Atlanta Bus Station, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 29h 31m.
The distance between Mississippi and Key West is 612 miles. The road distance is 1050.4 miles.
The best way to get from Mississippi to Key West without a car is to train and bus and ferry which takes 27h 16m and costs $320 - $420.
It takes approximately 5h 59m to get from Mississippi to Key West, including transfers.
Mississippi to Key West bus services, operated by Greyhound USA, depart from Jackson station.
The best way to get from Mississippi to Key West is to fly which takes 5h 59m and costs $140 - $700. Alternatively, you can bus, which costs $130 - $280 and takes 29h 31m.
Mississippi to Key West bus services, operated by Greyhound USA, arrive at Atlanta Bus Station.
Key West is 1h ahead of Mississippi. It is currently 11:47 PM in Mississippi and 12:47 AM in Key West.
What companies run services between Mississippi, USA and Key West, FL, USA?
Delta, American Airlines, and United Airlines fly from Gulfport-Biloxi Regional Airport (GPT) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a bus from Jackson to N Roosevelt & 3rd Street via Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 29h 31m.
- Website
- delta.com
Flights from Gulfport-Biloxi Regional Airport to Key West International Airport via Atlanta
- Ave. Duration
- 6h 19m
- When
- Every day
- Estimated price
- $120–650
Flights from Memphis to Key West International Airport via Atlanta
- Ave. Duration
- 4h 30m
- When
- Every day
- Estimated price
- $150–800
Flights from Jackson/Vicksburg to Key West International Airport via Atlanta
- Ave. Duration
- 5h 14m
- When
- Every day
- Estimated price
- $180–950
Flights from Golden Triangle Regional Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 19m
- When
- Every day
- Estimated price
- $100–550
- Website
- aa.com
Flights from Gulfport-Biloxi Regional Airport to Key West International Airport via Charlotte
- Ave. Duration
- 7h 37m
- When
- Every day
- Estimated price
- $150–700
Flights from Gulfport-Biloxi Regional Airport to Key West International Airport via Dallas/Ft.Worth
- Ave. Duration
- 10h 18m
- When
- Every day
- Estimated price
- $170–800
Flights from Memphis to Key West International Airport via Miami
- Ave. Duration
- 6h 30m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $150–800
Flights from Jackson/Vicksburg to Key West International Airport via Miami
- Ave. Duration
- 5h 9m
- When
- Saturday
- Estimated price
- $170–900
Flights from Jackson/Vicksburg to Key West International Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 12m
- When
- Every day
- Estimated price
- $250–1,200
Flights from Jackson/Vicksburg to Key West International Airport via Reagan Washington
- Ave. Duration
- 7h 46m
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- $290–1,300
Flights from Jackson/Vicksburg to Key West International Airport via Charlotte
- Ave. Duration
- 8h 5m
- When
- Every day
- Estimated price
- $220–1,100
- Website
- united.com
Flights from Gulfport-Biloxi Regional Airport to Key West International Airport via Houston
- Ave. Duration
- 7h 48m
- When
- Saturday
- Estimated price
- $140–700
Flights from Jackson/Vicksburg to Key West International Airport via Houston
- Ave. Duration
- 7h 53m
- When
- Saturday
- Estimated price
- $220–1,100
- Website
- flybreeze.com
Flights from Memphis to Key West International Airport via Orlando
- Ave. Duration
- 5h 46m
- When
- Monday and Friday
- Estimated price
- $150–800
Rome2Rio's guide to Amtrak
Contact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Jackson to New Orleans Union Passenger Terminal
- Ave. Duration
- 4h 27m
- Frequency
- Once daily
- Estimated price
- $30–70
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact Details
- Phone
- +1 214-849-8100
- ifsr@greyhound.com
- Website
- greyhound.com
Bus from New Orleans Bus Station to Biloxi Transit Center
- Ave. Duration
- 1h 45m
- Frequency
- Once daily
- Estimated price
- $17–25
- Website
- https://www.greyhound.com/
Bus from Jackson to Atlanta Bus Station
- Ave. Duration
- 8h 10m
- Frequency
- Twice daily
- Estimated price
- $50–75
- Website
- https://www.greyhound.com/
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 17h 20m
- Frequency
- Once daily
- Estimated price
- $65–130
- Website
- https://www.greyhound.com/
Bus from Miami Airport Station to Big Pine Key
- Ave. Duration
- 3h 35m
- Frequency
- 3 times a day
- Estimated price
- $21–30
- Website
- https://www.greyhound.com/
Bus from Jackson to Baton Rouge Bus Station
- Ave. Duration
- 5h 50m
- Frequency
- Once daily
- Estimated price
- $45–90
- Website
- https://www.greyhound.com/
- Phone
- +1 (855) 626-8585
- Website
- flixbus.com
Bus from New Orleans Bus Station to Biloxi Transit Center
- Ave. Duration
- 1h 25m
- Frequency
- 6 times a week
- Estimated price
- $17–26
- Schedules at
- flixbus.com
Bus from Atlanta Bus Station to Miami Airport Station
- Ave. Duration
- 13h 30m
- Frequency
- Once daily
- Estimated price
- $55–170
- Schedules at
- flixbus.com
Bus from Baton Rouge Bus Station to Lafayette
- Ave. Duration
- 55 min
- Frequency
- 3 times a day
- Estimated price
- $13–17
- Schedules at
- flixbus.com
- Phone
- +1 800-923-1799
- contactus@omexusa.net
- Website
- omnibusexpress.com
Bus from Biloxi to Fort Myers
- Ave. Duration
- 13h 31m
- Frequency
- Once daily
- Estimated price
- $120–150
- Schedules at
- omnibusexpress.com
- Phone
- +1 305-809-3700
- Website
- cityofkeywest-fl.gov
Bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Street
- Ave. Duration
- 1h 9m
- Frequency
- Every 3 hours
- Estimated price
- $2–4
- Schedules at
- https://www.cityofkeywest-fl.gov/595/Schedules-and-Route-Maps
- Phone
- +1 888 358 6762
- info@tornadobus.com
- Website
- tornadobus.com
Bus from Lafayette to Dolphin Mall - Miami
- Ave. Duration
- 19h 25m
- Frequency
- Once daily
- Estimated price
- $160–310
- Schedules at
- tornadobus.com
- Adults 11-59
- $160–310
- Phone
- (+1) 305-600-2226
- lyberi.com@gmail.com
- Website
- lyberi.com
Shuttle from Bayside Marketplace to Plaza Hotel
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $60
- Website
- https://lyberi.com
- Phone
- +1 239-463-5733
- Website
- keywestexpress.net
Ferry from Fort Myers Beach, FL to Key West, FL
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $130
- Website
- https://www.keywestexpress.net
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Why you should take the train in the US
Read the travel guide
Need to know: Greyhound
Read the travel guide
More Questions & Answers
Yes, the driving distance between Mississippi to Key West is 1050 miles. It takes approximately 18h 50m to drive from Mississippi to Key West.
There are 823+ hotels available in Key West.














