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There are 9 ways to get from Milwaukee to Sioux Falls by plane, bus, car or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly Milwaukee to Sioux Falls  •  6h 29m

  1. Fly from Milwaukee (MKE) to Sioux Falls (FSD) MKE - FSD

$204 - $1,104

Cheapest option

Bus Megabus  •  16h 41m

  1. Take the bus from Milwaukee, WI to St Paul, MN 4712 / ...
  2. Take the bus from Minneapolis, MN to Sioux Falls, SD 925

$92 - $174

7 alternative options

Bus to Chicago O'Hare, fly to Sioux Falls  •  5h 59m

  1. Take the bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
  2. Fly from Chicago O'Hare (ORD) to Sioux Falls (FSD) ORD - FSD

$193 - $505

Fly Milwaukee to Sioux City, drive  •  6h 30m

  1. Fly from Milwaukee (MKE) to Sioux City (SUX) MKE - SUX
  2. Drive from Sioux City to Sioux Falls

$201 - $966

Bus to Chicago O'Hare, fly to Sioux City, drive  •  5h 57m

  1. Take the bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
  2. Fly from Chicago O'Hare (ORD) to Sioux City (SUX) ORD - SUX
  3. Drive from Sioux City to Sioux Falls

$200 - $1,647

Train, bus via Burnsville, MN  •  13h 49m

  1. Take the train from Milwaukee Intermodal Station to St. Paul-Minneapolis Union Depot Empire Builder
  2. Take the bus from Burnsville, MN to Sioux Falls, SD 701

$136 - $258

Train, bus  •  16h 8m

  1. Take the train from Milwaukee Intermodal Station to St. Paul-Minneapolis Union Depot Empire Builder
  2. Take the bus from Minneapolis, MN to Sioux Falls, SD 925

$115 - $229

Bus  •  17h 10m

  1. Take the bus from Milwaukee to Minneapolis, MN 966 / ...
  2. Take the bus from Minneapolis, MN to Sioux Falls, SD 925

$128 - $179

Drive  •  8h 7m

  1. Drive from Milwaukee to Sioux Falls 504 miles

$45 - $75

Questions & Answers

The cheapest way to get from Milwaukee to Sioux Falls is to drive which costs $45 - $75 and takes 8h 7m.

More details

The quickest way to get from Milwaukee to Sioux Falls is to bus and fly and drive which costs $200 - $1,700 and takes 5h 57m.

More details

No, there is no direct bus from Milwaukee to Sioux Falls. However, there are services departing from Milwaukee, WI and arriving at The Bus Stop via Union Depot & Gate A1, Minneapolis, MN and Maple/Career NE corner. The journey, including transfers, takes approximately 16h 41m.

More details

The distance between Milwaukee and Sioux Falls is 446 miles. The road distance is 504 miles.

Get driving directions

The best way to get from Milwaukee to Sioux Falls without a car is to train and bus which takes 13h 49m and costs $130 - $260.

More details

It takes approximately 6h 29m to get from Milwaukee to Sioux Falls, including transfers.

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Milwaukee to Sioux Falls bus services, operated by Megabus, depart from Milwaukee, WI station.

More details

The best way to get from Milwaukee to Sioux Falls is to fly which takes 6h 29m and costs $200 - $1,100. Alternatively, you can bus, which costs $90 - $180 and takes 16h 41m.

Mode details

There is no direct flight from Milwaukee Airport to Sioux Falls Airport. The quickest flight takes 3h 39m and has one stopover.

Search flights

Milwaukee to Sioux Falls bus services, operated by Jefferson Lines, arrive at Sioux Falls, SD station.

More details

Map of how to get from Milwaukee to Sioux Falls.
Launch map view
  • Distance: 446 miles
  • Duration: 6h 29m

What companies run services between Milwaukee, WI, USA and Sioux Falls, SD, USA?

Delta, United Airlines and two other airlines fly from Milwaukee to Sioux Falls hourly. Alternatively, you can take a bus from Milwaukee to Sioux Falls via Union Depot & Gate A1, 5th St Transit Center & Platform A, Minneapolis, MN, Sioux Falls, SD, and Maple/Career NE corner in around 16h 41m.

Airlines
American Airlines
Website
aa.com
Flights from Milwaukee to Sioux Falls via Chicago O'Hare
Ave. Duration
5h 48m
When
Every day
Estimated price
$220 - $1,100
Flights from Milwaukee to Sioux Falls via Dallas/Ft.Worth
Ave. Duration
6h 57m
When
Wednesday and Saturday
Estimated price
$320 - $1,300
Flights from Chicago O'Hare to Sioux Falls
Ave. Duration
1h 50m
When
Every day
Estimated price
$320 - $950
Flights from Milwaukee to Sioux City via Chicago O'Hare
Ave. Duration
4h 56m
When
Every day
Estimated price
$190 - $950
Flights from Milwaukee to Sioux City via Dallas/Ft.Worth
Ave. Duration
7h 39m
When
Monday to Saturday
Estimated price
$280 - $1,200
Flights from Milwaukee to Sioux City via Chicago O'Hare, Dallas/Ft.Worth
Ave. Duration
7h 54m
When
Every day
Estimated price
$280 - $1,200
Flights from Chicago O'Hare to Sioux City
Ave. Duration
1h 46m
When
Every day
Estimated price
$310 - $1,600
United Airlines
Website
united.com
Flights from Milwaukee to Sioux Falls via Chicago O'Hare
Ave. Duration
4h 50m
When
Every day
Estimated price
$240 - $1,200
Flights from Milwaukee to Sioux Falls via Denver
Ave. Duration
6h 23m
When
Every day
Estimated price
$310 - $1,400
Flights from Chicago O'Hare to Sioux Falls
Ave. Duration
1h 53m
When
Every day
Estimated price
$300 - $750
Delta
Website
delta.com
Flights from Milwaukee to Sioux Falls via Minneapolis
Ave. Duration
4h 42m
When
Every day
Estimated price
$200 - $1,100
Flights from Milwaukee to Sioux Falls via Atlanta
Ave. Duration
6h 20m
When
Monday, Wednesday, Thursday, Friday, Saturday and Sunday
Estimated price
$300 - $1,400
Flights from Milwaukee to Sioux Falls via Detroit, Minneapolis
Ave. Duration
7h 21m
When
Monday to Friday
Estimated price
$240 - $1,200
Flights from Chicago O'Hare to Sioux Falls via Minneapolis
Ave. Duration
3h 47m
When
Every day
Estimated price
$340 - $950
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Milwaukee Intermodal Station to St. Paul-Minneapolis Union Depot
Ave. Duration
6h 11m
Frequency
3 times a day
Estimated price
$55 - $150
Website
amtrak.com
Coach Seat
$55 - $85
Flexi Coach Seat
$95 - $140
Business Coach Seat
$100 - $150
Room
$250 - $350
Bus operators
Coach USA
Phone
201-225-7500
Website
coachusa.com
Bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
Ave. Duration
1h 50m
Frequency
Hourly
Estimated price
$21 - $35
Schedules at
web.coachusa.com
Book at
coachusaairportexpress.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Burnsville, MN to Sioux Falls, SD
Ave. Duration
5h
Frequency
Once daily
Estimated price
$50 - $75
Book at
jeffersonlines.com
Bus from Minneapolis, MN to Sioux Falls, SD
Ave. Duration
6h 24m
Frequency
Once daily
Estimated price
$55 - $80
Book at
jeffersonlines.com
Bus from Milwaukee to Minneapolis, MN
Ave. Duration
8h 10m
Frequency
Twice daily
Estimated price
$70 - $100
Book at
jeffersonlines.com
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Milwaukee, Wi to St Paul, Mn
Ave. Duration
6h 55m
Frequency
3 times a day
Estimated price
$35 - $90
Website
greyhound.com
Economy
$35 - $60
Flexible
$65 - $90

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Yes, the driving distance between Milwaukee to Sioux Falls is 504 miles. It takes approximately 8h 7m to drive from Milwaukee to Sioux Falls.

Get driving directions

American Airlines, United Airlines and Delta offer flights from Milwaukee Airport to Sioux Falls Airport.

Search flights

There are 53+ hotels available in Sioux Falls. Prices start at $63 USD per night.

More details

The best way to get from Milwaukee to Milwaukee Airport is to bus which takes 29m and costs $3.

More details