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There are 10 ways to get from Milwaukee to Mayo Clinic by train, bus, car, plane or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train, bus  •  6 h 15 min

  1. Take the train from Milwaukee Intermodal Station to Winona Amtrak Empire Builder
  2. Take the bus from Winona, MN to Rochester, MN

$79 - $142

Cheapest option

Bus  •  6 h 18 min

  1. Take the bus from Milwaukee to Rochester, MN 966

$55 - $80

8 alternative options

Drive  •  4 h 33 min

  1. Drive from Milwaukee to Mayo Clinic 277.6 miles

$27 - $40

Fly Milwaukee to Rochester  •  5 h 45 min

  1. Fly from Milwaukee (MKE) to Rochester (RST) MKE - RST

$169 - $913

Fly Milwaukee to Minneapolis, shuttle  •  4 h 50 min

  1. Fly from Milwaukee (MKE) to Minneapolis (MSP) MKE - MSP
  2. Take a shuttle bus from Terminal 2 MSP to 2nd Street Rochester

$144 - $380

Bus to Chicago O'Hare, fly to Rochester  •  5 h 10 min

  1. Take the bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
  2. Fly from Chicago O'Hare (ORD) to Rochester (RST) ORD - RST

$178 - $744

Bus to Appleton, fly to Minneapolis, shuttle  •  6 h 50 min

  1. Take the bus from Milwaukee, Wi to Appleton, Wi
  2. Fly from Appleton (ATW) to Minneapolis (MSP) ATW - MSP
  3. Take a shuttle bus from Terminal 2 MSP to 2nd Street Rochester

$228 - $1,010

Bus to Madison, fly to Minneapolis, shuttle  •  7 h 5 min

  1. Take the bus from Milwaukee, WI to Madison - Langdon & N Park
  2. Fly from Madison (MSN) to Minneapolis (MSP) MSN - MSP
  3. Take a shuttle bus from Terminal 2 MSP to 2nd Street Rochester

$156 - $421

Amtrak Thruway to Green Bay, fly to Minneapolis, shuttle  •  6 h 47 min

  1. Take the Amtrak Thruway from Milwaukee, WI - Amtrak to Green Bay, WI
  2. Fly from Green Bay (GRB) to Minneapolis (MSP) GRB - MSP
  3. Take a shuttle bus from Terminal 2 MSP to 2nd Street Rochester

$208 - $820

Bus to Chicago O'Hare, fly to La Crosse, bus  •  7 h 23 min

  1. Take the bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
  2. Fly from Chicago O'Hare (ORD) to La Crosse (LSE) ORD - LSE
  3. Take the bus from La Crosse, WI to Rochester, MN

$215 - $727

Questions & Answers

The cheapest way to get from Milwaukee to Mayo Clinic is to drive which costs $27 - $40 and takes 4 h 33 min.

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The quickest way to get from Milwaukee to Mayo Clinic is to drive which costs $27 - $40 and takes 4 h 33 min.

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Yes, there is a direct bus departing from Milwaukee and arriving at Rochester, MN. Services depart once daily, and operate every day. The journey takes approximately 6 h 10 min.

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The distance between Milwaukee and Mayo Clinic is 240 miles. The road distance is 277.6 miles.

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The best way to get from Milwaukee to Mayo Clinic without a car is to train and bus which takes 6 h 15 min and costs $75 - $150.

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It takes approximately 6 h 15 min to get from Milwaukee to Mayo Clinic, including transfers.

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Milwaukee to Mayo Clinic bus services, operated by Jefferson Lines, depart from Milwaukee station.

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The best way to get from Milwaukee to Mayo Clinic is to bus which takes 6 h 18 min and costs $55 - $80. Alternatively, you can fly, which costs $160 - $950 and takes 5 h 45 min.

Mode details

There is no direct flight from Milwaukee Airport to Rochester Airport. The quickest flight takes 3 h 7 min and has one stopover.

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Milwaukee to Mayo Clinic bus services, operated by Jefferson Lines, arrive at Rochester, MN station.

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Map of how to get from Milwaukee to Mayo Clinic.
Launch map view
  • Distance: 239.7 miles
  • Duration: 6 h 15 min

What companies run services between Milwaukee, WI, USA and Mayo Clinic, MN, USA?

Jefferson Lines operates a bus from Milwaukee to Mayo Clinic once daily. Tickets cost $55 - $80 and the journey takes 6 h 10 min. Alternatively, Delta, United Airlines and two other airlines fly from Milwaukee to Mayo Clinic hourly.

Airlines
Delta
Website
delta.com
Flights from Milwaukee to Rochester via Minneapolis
Ave. Duration
3 h 49 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$160 - $900
Flights from Milwaukee to Rochester via Atlanta
Ave. Duration
6 h 58 min
When
Tuesday, Wednesday, Thursday and Friday
Estimated price
$240 - $1,100
Flights from Milwaukee to Rochester via Detroit, Minneapolis
Ave. Duration
6 h 4 min
When
Saturday
Estimated price
$190 - $950
Flights from Milwaukee to Minneapolis
Ave. Duration
1 h 21 min
When
Every day
Estimated price
$190 - $600
Flights from Chicago O'Hare to Rochester via Minneapolis
Ave. Duration
3 h 17 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$320 - $750
Flights from Appleton to Minneapolis
Ave. Duration
1 h 18 min
When
Every day
Estimated price
$160 - $900
Flights from Madison to Minneapolis
Ave. Duration
1 h 13 min
When
Every day
Estimated price
$170 - $480
Flights from Green Bay to Minneapolis
Ave. Duration
1 h 21 min
When
Every day
Estimated price
$120 - $700
American Airlines
Website
aa.com
Flights from Milwaukee to Rochester via Chicago O'Hare
Ave. Duration
4 h 34 min
When
Every day
Estimated price
$170 - $900
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 13 min
When
Every day
Estimated price
$260 - $750
Flights from Chicago O'Hare to La Crosse
Ave. Duration
1 h 13 min
When
Every day
Estimated price
$260 - $850
United Airlines
Website
united.com
Flights from Milwaukee to Rochester via Chicago O'Hare
Ave. Duration
3 h 54 min
When
Every day
Estimated price
$180 - $900
Flights from Milwaukee to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 28 min
When
Every day
Estimated price
$200 - $750
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 21 min
When
Every day
Estimated price
$150 - $750
Train operators
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Train from Milwaukee Intermodal Station to Winona Amtrak
Ave. Duration
3 h 49 min
Frequency
3 times a day
Estimated price
$40 - $110
Website
amtrak.com
Coach Seat
$40 - $65
Flexi Coach Seat
$75 - $110
Business Coach Seat
$75 - $110
Room
$210 - $290
Bus operators
Go Carefree Shuttle
Website
gocarefreeshuttle.com
Bus from Winona, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 4 hours
Estimated price
$35
Schedules at
gocarefreeshuttle.com
Bus from La Crosse, WI to Rochester, MN
Ave. Duration
1 h 50 min
Frequency
Every 4 hours
Estimated price
$44
Schedules at
gocarefreeshuttle.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Milwaukee to Rochester, MN
Ave. Duration
6 h 10 min
Frequency
Once daily
Estimated price
$55 - $80
Book at
jeffersonlines.com
Bus from Milwaukee to Green Bay, WI
Ave. Duration
2 h 15 min
Frequency
Once daily
Estimated price
$28 - $40
Book at
jeffersonlines.com
Groome Transport
Website
groometransportation.com
Shuttle from Terminal 2 MSP to 2nd Street Rochester
Ave. Duration
1 h 25 min
Frequency
Hourly
Estimated price
$30 - $45
Schedules at
groometransportation.com
Coach USA
Greyhound USA

Greyhound is a leading bus company based in Dallas, Texas, serving over 3800 destinations across North America, Mexico and Canada. Greyhound carries around 18 million passengers a year who travel 5.4 billion miles (8.6 billion km) a year on their fleet of around 1700 vehicles. For travel flexibility, you can board or get off a Greyhound bus at official Greyhound stations, partner stations and curbside stops. There are around 230 Greyhound stations across the US where you can both catch your bus and buy tickets, that are also available on the official website and via the mobile app.

Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Milwaukee, Wi to Appleton, Wi
Ave. Duration
2 h 20 min
Frequency
Once daily
Estimated price
$16 - $40
Website
greyhound.com
Economy
$16 - $25
Flexible
$29 - $40
Lamers Bus Lines
Phone
+1 800-236-1240
Website
golamers.com
Bus from Milwaukee, WI to Appleton
Ave. Duration
2 h 25 min
Frequency
Once daily
Estimated price
$24 - $30
Schedules at
golamers.com
Book at
webstore.golamers.com
Megabus
Amtrak

Amtrak is a rail service that connects the US and three Canadian provinces. Covering 21,000 route miles (34,000km) Amtrak operates more than 300 trains daily. These medium and long distance intercity services operate at speeds of up to 240km/h, to more than 500 destinations. Founded in 1971, it is based in Washington, D.C. and offers four classes of travel: First Class, Sleeper, Business and Coach. Ticket fares are divided into five subclasses: Saver, Value, Flexible, Business and Premium. Amtrak trains are known for their wide seats, plug-in power, big windows and storage capabilities.

Rome2rio's guide to Amtrak
Contact Details
Phone
+1 215-856-7924
Website
amtrak.com
Bus from Milwaukee, WI - Amtrak to Green Bay, WI
Ave. Duration
2 h 15 min
Frequency
3 times a day
Website
amtrak.com

Want to know more about travelling around United States

Rome2rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

More Questions & Answers

Yes, the driving distance between Milwaukee to Mayo Clinic is 278 miles. It takes approximately 4 h 33 min to drive from Milwaukee to Mayo Clinic.

Get driving directions

United Airlines, American Airlines and Delta offer flights from Milwaukee Airport to Rochester Airport.

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There are 57+ hotels available in Mayo Clinic. Prices start at $67 USD per night.

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The best way to get from Milwaukee to Milwaukee Airport is to bus which takes 28 min and costs $3.

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