There are 6 ways to get from Milwaukee to Mayo Clinic by train, bus, car or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Train, bus  •  6 h 15 min

  1. Take the train from Milwaukee Intermodal Station Amtrak to Winona Amtrak Empire Builder
  2. Take the bus from Winona, MN to Rochester, MN

$79 - $142

Cheapest option

Bus  •  6 h 18 min

  1. Take the bus from Milwaukee to Rochester, MN 966

$55 - $80

4 alternative options

Drive  •  4 h 33 min

  1. Drive from Milwaukee to Mayo Clinic 277.6 miles

$27 - $40

Fly Milwaukee to Rochester  •  5 h 54 min

  1. Fly from Milwaukee (MKE) to Rochester (RST) MKE - RST

$169 - $926

Fly Milwaukee to Minneapolis, bus  •  5 h 13 min

  1. Fly from Milwaukee (MKE) to Minneapolis (MSP) MKE - MSP
  2. Take the bus from Minneapolis-St Paul Airport, MN to Rochester, MN

$134 - $380

Bus to Chicago O'Hare, fly to Rochester  •  5 h 17 min

  1. Take the bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
  2. Fly from Chicago O'Hare (ORD) to Rochester (RST) ORD - RST

$178 - $744

What companies run services between Milwaukee, WI, USA and Mayo Clinic, MN, USA?

Jefferson Lines operates a bus from Milwaukee to Mayo Clinic every 3 hours. Tickets cost $55 - $80 and the journey takes 6 h 10 min. Alternatively, Delta, United Airlines and two other airlines fly from Milwaukee to Mayo Clinic hourly.

Airlines
Delta
Website
delta.com
Flights from Milwaukee to Rochester via Minneapolis
Ave. Duration
3 h 31 min
When
Every day
Estimated price
$160 - $900
Flights from Milwaukee to Rochester via Detroit, Minneapolis
Ave. Duration
5 h 49 min
When
Tuesday, Wednesday, Thursday and Sunday
Estimated price
$190 - $950
Flights from Milwaukee to Rochester via Covington, Minneapolis
Ave. Duration
6 h 23 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$200 - $1,000
Flights from Milwaukee to Minneapolis
Ave. Duration
1 h 23 min
When
Every day
Estimated price
$190 - $600
Flights from Chicago O'Hare to Rochester via Minneapolis
Ave. Duration
3 h 16 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$320 - $750
United Airlines
Website
united.com
Flights from Milwaukee to Rochester via Chicago O'Hare
Ave. Duration
3 h 50 min
When
Every day
Estimated price
$180 - $900
Flights from Milwaukee to Minneapolis via Chicago O'Hare
Ave. Duration
3 h 29 min
When
Every day
Estimated price
$200 - $750
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 20 min
When
Every day
Estimated price
$150 - $750
American Airlines
Website
aa.com
Flights from Milwaukee to Rochester via Chicago O'Hare
Ave. Duration
4 h 16 min
When
Every day
Estimated price
$170 - $900
Flights from Chicago O'Hare to Rochester
Ave. Duration
1 h 16 min
When
Every day
Estimated price
$260 - $750
Train operators
Amtrak
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Milwaukee Intermodal Station Amtrak to Winona Amtrak
Ave. Duration
3 h 49 min
Frequency
3 times a day
Estimated price
$40 - $110
Website
amtrak.com
Coach Seat
$40 - $65
Flexi Coach Seat
$75 - $110
Business Coach Seat
$75 - $110
Room
$210 - $290
Bus operators
Go Carefree Shuttle
Website
gocarefreeshuttle.com
Bus from Winona, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 4 hours
Estimated price
$35
Schedules at
gocarefreeshuttle.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Milwaukee to Rochester, MN
Ave. Duration
6 h 10 min
Frequency
Every 3 hours
Estimated price
$55 - $80
Schedules at
jeffersonlines.com
Bus from Minneapolis-St Paul Airport, MN to Rochester, MN
Ave. Duration
1 h 20 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Schedules at
jeffersonlines.com
Coach USA
Phone
201-225-7500
Website
coachusa.com
Bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
Ave. Duration
1 h 50 min
Frequency
Hourly
Estimated price
$21 - $35
Schedules at
coachusa.com
Book at
coachusaairportexpress.com

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Questions & Answers

How far is it from Milwaukee to Mayo Clinic?

The distance between Milwaukee and Mayo Clinic is 383 km. The road distance is 444 km.

What is the cheapest way to get from Milwaukee to Mayo Clinic?

The cheapest way to get from Milwaukee to Mayo Clinic is to drive which costs $27 - $40 and takes 4 h 33 min.

What is the fastest way to get from Milwaukee to Mayo Clinic?

The quickest way to get from Milwaukee to Mayo Clinic is to drive which takes 4 h 33 min and costs $27 - $40.

Is there a direct bus between Milwaukee and Mayo Clinic?

Yes, there is a direct bus departing from Milwaukee and arriving at Rochester, MN. Services depart every three hours, and operate every day. The journey takes approximately 6 h 10 min.

How long does it take to get from Milwaukee to Mayo Clinic?

It takes approximately 6 h 15 min to get from Milwaukee to Mayo Clinic, including transfers.