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How to get fromMilwaukee to Des Moinesby plane, train, bus, car, bus (Flixbus, Greyhound) or bus (Greyhound)

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There are 7 ways to get from Milwaukee to Des Moines by plane, train, bus, car, bus (Flixbus, Greyhound), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from General Mitchell International Airport

    best
    1. Fly from General Mitchell International Airport (MKE) to Des Moines (DSM)plane plane MKE - DSM
    5h 13m
    $199–1,223

  2. Drive 354.8 mi

    cheapest
    1. Drive from Milwaukee to Des Moinescar car 354.8 mi
    6h 23m
    $65–94

  3. Train, bus

    1. Take the train from Milwaukee to Chicago Union Stationtrain train Hiawatha Service / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0155S
    11h 3m
    $78–159

  4. Bus to Chicago O'Hare International Airport, fly

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    2. Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane plane ORD - DSM
    4h 23m
    $136–613

  5. Train to Chicago Midway International Airport, fly

    1. Take the train from Milwaukee to Chicago Union Stationtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane plane MDW - DSM
    5h 5m
    $162–875

  6. Bus

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus bus FlixBus 2548 / ...
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0155S
    11h 40m
    $66–139

  7. Bus via Chicago O'Hare Airport (ORD)

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus Wisconsin Coach Lines
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0155S
    12h 18m
    $96–157

Milwaukee to Des Moines by train, foot, and bus

Calendar7Weekly Services
Duration11h 3mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

What companies run services between Milwaukee, WI, USA and Des Moines, IA, USA?

United Airlines, Delta, and two other airlines fly from General Mitchell International Airport (MKE) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Milwaukee Intermodal Station to Des Moines via Chicago Bus Station in around 11h 40m.

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