There are 8 ways to get from Milwaukee to Des Moines by plane, bus, train or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2rio's travel planner.

Recommended option

Fly from Milwaukee  •  5 h 40 min

  1. Fly from Milwaukee (MKE) to Des Moines (DSM) MKE - DSM

$154 - $804

Cheapest option

Bus Burlington Trailways  •  9 h 50 min

  1. Take the bus from Milwaukee, Wi to Chicago, Il 4727 / ...
  2. Take the bus from Chicago, IL to Des Moines, IA 1205 / ...

$62 - $117

6 alternative options

Bus to Chicago O'Hare, fly  •  5 h 16 min

  1. Take the bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport
  2. Fly from Chicago O'Hare (ORD) to Des Moines (DSM) ORD - DSM

$173 - $735

Train, bus  •  9 h 31 min

  1. Take the train from Milwaukee Intermodal Station Amtrak to Chicago Union Station Amtrak Hiawatha Service
  2. Take the bus from Chicago, IL to Des Moines, IA 1205 / ...

$70 - $105

Bus Windstar  •  10 h 24 min

  1. Take the bus from Milwaukee, WI - Amtrak to Chicago, IL - O'Hare International Airport Airport Express to Chicago O'hare / ...
  2. Take the bus from Chicago, IL to Des Moines, IA West Bound

Train, bus via Ottumwa, IA  •  11 h 2 min

  1. Take the train from Milwaukee Intermodal Station Amtrak to Chicago Union Station Amtrak
  2. Take the train from Chicago Union Station Amtrak to Ottumwa Amtrak
  3. Take the bus from Ottumwa, IA to Monroe, IA
  4. Take the bus from Monroe, IA to Des Moines, IA

$123 - $230

Bus via Dubuque, IA  •  12 h 15 min

  1. Take the bus from Milwaukee to Madison 966
  2. Take the bus from Madison, WI - Univ. of Wisconsin to Dubuque, IA 122
  3. Take the bus from Dubuque, IA to Des Moines, IA

$93 - $128

Drive  •  6 h 6 min

  1. Drive from Milwaukee to Des Moines 375.1 miles

$35 - $55

Questions & Answers

The cheapest way to get from Milwaukee to Des Moines is to drive which costs $35 - $55 and takes 6 h 6 min.

More details

The quickest way to get from Milwaukee to Des Moines is to bus and fly which costs $170 - $750 and takes 5 h 16 min.

More details

The distance between Milwaukee and Des Moines is 310 miles. The road distance is 375.1 miles.

Get driving directions

It takes approximately 5 h 40 min to get from Milwaukee to Des Moines, including transfers.

More details

No, there is no direct bus from Milwaukee to Des Moines. However, there are services departing from Milwaukee and arriving at Des Moines, IA via Madison, WI - Univ. of Wisconsin and Dubuque, IA. The journey, including transfers, takes approximately 12 h 15 min.

More details

Southwest Airlines, American Airlines, United Airlines and Delta offer flights from Milwaukee Airport to Des Moines Airport.

Search flights

Milwaukee to Des Moines bus services, operated by Jefferson Lines, arrive at Minneapolis station.

More details

Map of how to get from Milwaukee to Des Moines.
Launch map view
  • Distance: 309.5 miles
  • Duration: 5 h 40 min

What companies run services between Milwaukee, WI, USA and Des Moines, IA, USA?

Southwest Airlines, American Airlines and two other airlines fly from Milwaukee to Des Moines hourly. Alternatively, you can take a bus from Milwaukee to Des Moines via Chicago, Il, UIC-Halsted, Clinton-Blue, and Chicago, IL in around 9 h 50 min.

Airlines
United Airlines
Website
united.com
Flights from Milwaukee to Des Moines via Chicago O'Hare
Ave. Duration
4 h 5 min
When
Every day
Estimated price
$170 - $850
Flights from Chicago O'Hare to Des Moines
Ave. Duration
1 h 24 min
When
Every day
Estimated price
$290 - $1,400
American Airlines
Website
aa.com
Flights from Milwaukee to Des Moines via Chicago O'Hare
Ave. Duration
3 h 47 min
When
Every day
Estimated price
$150 - $800
Flights from Milwaukee to Des Moines via Dallas/Ft.Worth
Ave. Duration
5 h 18 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$240 - $1,000
Flights from Chicago O'Hare to Des Moines
Ave. Duration
1 h 17 min
When
Every day
Estimated price
$330 - $1,100
Delta
Website
delta.com
Flights from Milwaukee to Des Moines via Minneapolis
Ave. Duration
4 h 12 min
When
Every day
Estimated price
$150 - $800
Flights from Milwaukee to Des Moines via Detroit
Ave. Duration
4 h 42 min
When
Every day
Estimated price
$170 - $850
Flights from Milwaukee to Des Moines via Atlanta
Ave. Duration
5 h 10 min
When
Every day
Estimated price
$210 - $1,000
Southwest Airlines
Website
southwest.com
Flights from Milwaukee to Des Moines via St. Louis
Ave. Duration
3 h 51 min
When
Monday, Tuesday, Wednesday, Thursday, Friday and Sunday
Estimated price
$180 - $800
Train operators
Amtrak
Rome2rio's guide to Amtrak
Contact Details
Phone
+1 1-800-872-7245
Website
amtrak.com
Train from Milwaukee Intermodal Station Amtrak to Chicago Union Station Amtrak
Ave. Duration
1 h 29 min
Frequency
Every 4 hours
Estimated price
$25
Website
amtrak.com
Coach Seat
$25
Train from Chicago Union Station Amtrak to Ottumwa Amtrak
Ave. Duration
4 h 53 min
Frequency
Once daily
Estimated price
$50 - $130
Website
amtrak.com
Coach Seat
$50 - $75
Flexi Coach Seat
$90 - $130
Business Coach Seat
$90 - $130
Room
$230 - $320
Bus operators
Coach USA
Burlington Trailways
Website
burlingtontrailways.com
Bus from Chicago, IL to Des Moines, IA
Ave. Duration
6 h 50 min
Frequency
Every 3 hours
Estimated price
$45 - $80
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Ottumwa, IA to Monroe, IA
Ave. Duration
55 min
Frequency
Once a week
Estimated price
$25 - $40
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Monroe, IA to Des Moines, IA
Ave. Duration
45 min
Frequency
Once a week
Estimated price
$23 - $35
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Bus from Dubuque, IA to Des Moines, IA
Ave. Duration
6 h 20 min
Frequency
Once daily
Estimated price
$50 - $70
Schedules at
burlingtontrailways.com
Book at
burlingtontrailways.com
Greyhound USA
Rome2rio's guide to Greyhound USA
Contact Details
Phone
+1 214-849-8100/1-800-231-2222
Email
ifsr@greyhound.com
Website
greyhound.com
Bus from Milwaukee, Wi to Chicago, Il
Ave. Duration
1 h 55 min
Frequency
Every 30 minutes
Estimated price
$15 - $35
Website
greyhound.com
Economy
$15 - $23
Flexible
$27 - $35
Windstar
Phone
+1 888-494-6378
Email
sara@gowindstar.com
Website
gowindstar.com
Bus from Chicago, IL to Des Moines, IA
Ave. Duration
6 h 40 min
Frequency
Once daily
Schedules at
gowindstar.com
Jefferson Lines
Phone
800-451-5333
Email
info@jeffersonlines.com
Website
jeffersonlines.com
Bus from Milwaukee to Madison
Ave. Duration
1 h 20 min
Frequency
Every 3 hours
Estimated price
$22 - $35
Schedules at
jeffersonlines.com
Badger Bus
Website
badgerbus.com
Bus from Milwaukee, WI to Madison, WI - Chazen UW Madison
Ave. Duration
1 h 40 min
Frequency
Every 4 hours
Estimated price
$20 - $23
Schedules at
badgerbus.com
Book at
badgerbus.com
Lamers Bus Lines
Phone
+1 800-236-1240
Website
golamers.com
Bus from Madison, WI - Univ. of Wisconsin to Dubuque, IA
Ave. Duration
2 h 35 min
Frequency
Once daily
Estimated price
$22 - $28
Schedules at
golamers.com
Book at
webstore.golamers.com

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