Rome2Rio

How to get fromMilwaukee to Defianceby train (Amtrak), bus, taxi, car, plane or train

Find Transport to Defiance

See all options

There are 5 ways to get from Milwaukee to Defiance by train (Amtrak), bus, taxi, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Milwaukee to Chicago Union StationtrainHiawatha Service / ...
    2. Take the train from Chicago Union Station to Bryan Amtrak StationtrainLake Shore Limited
    6h 12m
    $119–178

  2. Drive 286 mi

    cheapest
    1. Drive from Milwaukee to Defiancecar286 mi
    5h 56m
    $53–76

  3. Bus, taxi

    1. Take the bus from Milwaukee Intermodal Station to Chicago Bus Stationbus
    2. Take the bus from Chicago to Van Wertbus
    3. Take the taxi from Van Wert to Defiancetaxi
    8h 37m
    $130–240

  4. Bus, fly, taxi

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus
    2. Fly from Chicago O'Hare International Airport (ORD) to Fort Wayne International Airport (FWA)planeORD - FWA
    3. Take the taxi from Fort Wayne International Airport (FWA) to Defiancetaxi
    5h 2m
    $205–468

  5. Bus, train

    1. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 DeparturesbusWisconsin Coach Lines
    2. Take the train from Chicago Union Station to Bryan Amtrak StationtrainLake Shore Limited
    7h 29m
    $132–183

Chicago O'Hare International Airport (ORD) to Fort Wayne International Airport (FWA) flights

Calendar55Weekly Planes
Duration1h 14mAverage Duration
Ticket$34Cheapest Price
See schedules

Questions & Answers

What companies run services between Milwaukee, WI, USA and Defiance, OH, USA?

You can take a train from Milwaukee to Defiance via Chicago Union Station and Bryan Amtrak Station in around 6h 12m.

Transport is disrupted due to the Russia-Ukraine war. Read more

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Trips from Milwaukee

Trips to Defiance

Popular routes